C48

Name Value
Weight 0.000 N/A
Zinc ID N/A
Smiles N/A
Molecular formula N/A
Mode of inhibition Direct STAT
CAS N/A

Clinical Trials

Study title Status Conditions Link

References

Publication DOI Pubmed PMCID
Cost-effective choice of antimicrobial therapy for serious infections. Journal of general internal medicine M C Weinstein, J L Read, D N MacKay, J J Kresel, H Ashley, K T Halvorsen, H C Hutchings, 1, 6, None, None, 10.1021/cb100253e 10.1021/cb100253e 3098940 PMC3098940

Filter data

Compound C48
Experiment types EMSA, Flow cytometry- Annexin, Immunostaining , Luciferase activity, Tumor volume, Western Blot
Concentrations 1.00, 10.00, 100.00, 20.00, 200.00, 3.00, 30.00, 300.00, 40.00, 400.00, 50.00, 500.00
Cell lines HeLa-Stat1-Luc, HeLa-Stat3-Luc, LNCaP, MDA-MB-231, MDA-MB-468, MDA-MB-468 (xenograft), MEF-Stat3-YFP, SK-MEL-5
Organisms Homo sapiens, Mus musculus
Animal models C3H/HeJ syngeneic mice, athymic nude mice
STAT proteins STAT1, STAT1:STAT1, STAT1:STAT3, STAT3, STAT3:STAT3, p-STAT3 (Y705)
Other Actin, JAK2, Mcl-1, PARP, SRC, p-JAK2 (Y1007/1008), p-SRC (Y416), p-p44/p42, p-p44/p42 (Y202/Y204)

Experiments

Compound Experiment type Investigated event Concentration Cell line Organism Animal model Stat protein Details
C48 EMSA Influence on protein-DNA interaction 3.00 µM SK-MEL-5 Homo sapiens STAT3:STAT3
C48 EMSA Influence on protein-DNA interaction 10.00 µM SK-MEL-5 Homo sapiens STAT3:STAT3
C48 EMSA Influence on protein-DNA interaction 30.00 µM SK-MEL-5 Homo sapiens STAT3:STAT3
C48 EMSA Influence on protein-DNA interaction 50.00 µM SK-MEL-5 Homo sapiens STAT3:STAT3
C48 EMSA Influence on protein-DNA interaction 100.00 µM SK-MEL-5 Homo sapiens STAT3:STAT3
C48 EMSA Influence on protein-DNA interaction 200.00 µM SK-MEL-5 Homo sapiens STAT3:STAT3
C48 EMSA Influence on protein-DNA interaction 300.00 µM SK-MEL-5 Homo sapiens STAT3:STAT3
C48 EMSA Influence on protein-DNA interaction 400.00 µM SK-MEL-5 Homo sapiens STAT3:STAT3
C48 EMSA Influence on protein-DNA interaction 500.00 µM SK-MEL-5 Homo sapiens STAT3:STAT3
C48 EMSA Influence on protein-DNA interaction 3.00 µM SK-MEL-5 Homo sapiens STAT1:STAT3
C48 EMSA Influence on protein-DNA interaction 10.00 µM SK-MEL-5 Homo sapiens STAT1:STAT3
C48 EMSA Influence on protein-DNA interaction 30.00 µM SK-MEL-5 Homo sapiens STAT1:STAT3
C48 EMSA Influence on protein-DNA interaction 50.00 µM SK-MEL-5 Homo sapiens STAT1:STAT3
C48 EMSA Influence on protein-DNA interaction 100.00 µM SK-MEL-5 Homo sapiens STAT1:STAT3
C48 EMSA Influence on protein-DNA interaction 200.00 µM SK-MEL-5 Homo sapiens STAT1:STAT3
C48 EMSA Influence on protein-DNA interaction 300.00 µM SK-MEL-5 Homo sapiens STAT1:STAT3
C48 EMSA Influence on protein-DNA interaction 400.00 µM SK-MEL-5 Homo sapiens STAT1:STAT3
C48 EMSA Influence on protein-DNA interaction 500.00 µM SK-MEL-5 Homo sapiens STAT1:STAT3
C48 EMSA Influence on protein-DNA interaction 3.00 µM SK-MEL-5 Homo sapiens STAT1:STAT1
C48 EMSA Influence on protein-DNA interaction 10.00 µM SK-MEL-5 Homo sapiens STAT1:STAT1
C48 EMSA Influence on protein-DNA interaction 30.00 µM SK-MEL-5 Homo sapiens STAT1:STAT1
C48 EMSA Influence on protein-DNA interaction 50.00 µM SK-MEL-5 Homo sapiens STAT1:STAT1
C48 EMSA Influence on protein-DNA interaction 100.00 µM SK-MEL-5 Homo sapiens STAT1:STAT1
C48 EMSA Influence on protein-DNA interaction 200.00 µM SK-MEL-5 Homo sapiens STAT1:STAT1
C48 EMSA Influence on protein-DNA interaction 300.00 µM SK-MEL-5 Homo sapiens STAT1:STAT1
C48 EMSA Influence on protein-DNA interaction 400.00 µM SK-MEL-5 Homo sapiens STAT1:STAT1
C48 EMSA Influence on protein-DNA interaction 500.00 µM SK-MEL-5 Homo sapiens STAT1:STAT1
C48 Immunostaining Influence protein translocation in presence of oncostatin-M 30.00 µM MEF-Stat3-YFP Mus musculus STAT3
C48 Immunostaining Influence protein translocation in presence of oncostatin-M 40.00 µM MEF-Stat3-YFP Mus musculus STAT3
C48 Immunostaining Influence protein translocation in presence of oncostatin-M 50.00 µM MEF-Stat3-YFP Mus musculus STAT3
C48 Luciferase activity Influnce on protein transcriptional activity in presence of oncostatin-M 1.00 µM HeLa-Stat3-Luc Homo sapiens STAT3
C48 Luciferase activity Influnce on protein transcriptional activity in presence of oncostatin-M 3.00 µM HeLa-Stat3-Luc Homo sapiens STAT3
C48 Luciferase activity Influnce on protein transcriptional activity in presence of oncostatin-M 10.00 µM HeLa-Stat3-Luc Homo sapiens STAT3
C48 Luciferase activity Influnce on protein transcriptional activity in presence of oncostatin-M 20.00 µM HeLa-Stat3-Luc Homo sapiens STAT3
C48 Luciferase activity Influnce on protein transcriptional activity in presence of IFNγ 1.00 µM HeLa-Stat1-Luc Homo sapiens STAT1
C48 Luciferase activity Influnce on protein transcriptional activity in presence of IFNγ 3.00 µM HeLa-Stat1-Luc Homo sapiens STAT1
C48 Luciferase activity Influnce on protein transcriptional activity in presence of IFNγ 10.00 µM HeLa-Stat1-Luc Homo sapiens STAT1
C48 Luciferase activity Influnce on protein transcriptional activity in presence of IFNγ 20.00 µM HeLa-Stat1-Luc Homo sapiens STAT1
C48 Flow cytometry- Annexin Influence on cell viability 1.00 µM MDA-MB-468 Homo sapiens
C48 Flow cytometry- Annexin Influence on cell viability 3.00 µM MDA-MB-468 Homo sapiens
C48 Flow cytometry- Annexin Influence on cell viability 10.00 µM MDA-MB-468 Homo sapiens
C48 Flow cytometry- Annexin Influence on cell viability 20.00 µM MDA-MB-468 Homo sapiens
C48 Flow cytometry- Annexin Influence on cell viability 1.00 µM MDA-MB-231 Homo sapiens
C48 Flow cytometry- Annexin Influence on cell viability 3.00 µM MDA-MB-231 Homo sapiens
C48 Flow cytometry- Annexin Influence on cell viability 10.00 µM MDA-MB-231 Homo sapiens
C48 Flow cytometry- Annexin Influence on cell viability 20.00 µM MDA-MB-231 Homo sapiens
C48 Flow cytometry- Annexin Influence on cell viability 1.00 µM LNCaP Homo sapiens
C48 Flow cytometry- Annexin Influence on cell viability 3.00 µM LNCaP Homo sapiens
C48 Flow cytometry- Annexin Influence on cell viability 10.00 µM LNCaP Homo sapiens
C48 Flow cytometry- Annexin Influence on cell viability 20.00 µM LNCaP Homo sapiens
C48 Western Blot Infleunce on protein activity 1.00 µM MDA-MB-468 Homo sapiens p-STAT3 (Y705)
C48 Western Blot Infleunce on protein activity 3.00 µM MDA-MB-468 Homo sapiens p-STAT3 (Y705)
C48 Western Blot Infleunce on protein activity 10.00 µM MDA-MB-468 Homo sapiens p-STAT3 (Y705)
C48 Western Blot Infleunce on protein activity 20.00 µM MDA-MB-468 Homo sapiens p-STAT3 (Y705)
C48 Western Blot Infleunce on protein activity 1.00 µM MDA-MB-468 Homo sapiens STAT3
C48 Western Blot Infleunce on protein activity 3.00 µM MDA-MB-468 Homo sapiens STAT3
C48 Western Blot Infleunce on protein activity 10.00 µM MDA-MB-468 Homo sapiens STAT3
C48 Western Blot Infleunce on protein activity 20.00 µM MDA-MB-468 Homo sapiens STAT3
C48 Western Blot Infleunce on protein activity 1.00 µM MDA-MB-468 Homo sapiens
C48 Western Blot Infleunce on protein activity 3.00 µM MDA-MB-468 Homo sapiens
C48 Western Blot Infleunce on protein activity 10.00 µM MDA-MB-468 Homo sapiens
C48 Western Blot Infleunce on protein activity 20.00 µM MDA-MB-468 Homo sapiens
C48 Western Blot Infleunce on protein activity 1.00 µM MDA-MB-468 Homo sapiens
C48 Western Blot Infleunce on protein activity 3.00 µM MDA-MB-468 Homo sapiens
C48 Western Blot Infleunce on protein activity 10.00 µM MDA-MB-468 Homo sapiens
C48 Western Blot Infleunce on protein activity 20.00 µM MDA-MB-468 Homo sapiens
C48 Western Blot Infleunce on protein activity 1.00 µM MDA-MB-468 Homo sapiens
C48 Western Blot Infleunce on protein activity 3.00 µM MDA-MB-468 Homo sapiens
C48 Western Blot Infleunce on protein activity 10.00 µM MDA-MB-468 Homo sapiens
C48 Western Blot Infleunce on protein activity 20.00 µM MDA-MB-468 Homo sapiens
C48 Western Blot Infleunce on protein activity 1.00 µM MDA-MB-468 Homo sapiens
C48 Western Blot Infleunce on protein activity 3.00 µM MDA-MB-468 Homo sapiens
C48 Western Blot Infleunce on protein activity 10.00 µM MDA-MB-468 Homo sapiens
C48 Western Blot Infleunce on protein activity 20.00 µM MDA-MB-468 Homo sapiens
C48 Western Blot Infleunce on protein activity 1.00 µM MDA-MB-468 Homo sapiens
C48 Western Blot Infleunce on protein activity 3.00 µM MDA-MB-468 Homo sapiens
C48 Western Blot Infleunce on protein activity 10.00 µM MDA-MB-468 Homo sapiens
C48 Western Blot Infleunce on protein activity 20.00 µM MDA-MB-468 Homo sapiens
C48 Western Blot Infleunce on protein activity 50.00 µM MDA-MB-468 Homo sapiens
C48 Western Blot Infleunce on protein activity 50.00 µM MDA-MB-468 Homo sapiens
C48 Western Blot Infleunce on protein activity 50.00 µM MDA-MB-468 Homo sapiens
C48 Western Blot Infleunce on protein activity 50.00 µM MDA-MB-468 Homo sapiens
C48 Western Blot Influence on protein activity in presecne of Na3VO4 50.00 µM MDA-MB-468 Homo sapiens p-STAT3 (Y705)
C48 Western Blot Influence on protein activity in presecne of Na3VO4 50.00 µM MDA-MB-468 Homo sapiens STAT3
C48 Tumor volume Influence on tumor growth 200.00 mg/kg MDA-MB-468 (xenograft) Mus musculus athymic nude mice
C48 Tumor volume Influence on tumor growth 200.00 mg/kg MDA-MB-468 (xenograft) Mus musculus C3H/HeJ syngeneic mice
C48 Tumor volume Influence on tumor growth 100.00 mg/kg MDA-MB-468 (xenograft) Mus musculus C3H/HeJ syngeneic mice