AS1517499

Name Value
Weight 397.866 g/mol
Zinc ID ZINC28641215
Smiles NC(=O)c1cnc(NCCc2ccc(O)c(Cl)c2)nc1NCc1ccccc1
Molecular formula C20H20ClN5O2
Mode of inhibition Direct STAT
CAS N/A

Clinical Trials

Study title Status Conditions Link

Visualization

References

Publication DOI Pubmed PMCID
A novel STAT6 inhibitor AS1517499 ameliorates antigen-induced bronchial hypercontractility in mice. American journal of respiratory cell and molecular biology Yoshihiko Chiba, Michiko Todoroki, Yuichi Nishida, Miki Tanabe, Miwa Misawa, 41, 5, None, 2009-02-06, 10.1165/rcmb.2008-0163OC 10.1165/rcmb.2008-0163OC 19202006 19202006
Targeting the Stat6 pathway in tumor-associated macrophages reduces tumor growth and metastatic niche formation in breast cancer. FASEB journal : official publication of the Federation of American Societies for Experimental Biology Karin Binnemars-Postma, Ruchi Bansal, Gert Storm, Jai Prakash, 32, 2, None, 2018-01-03, 10.1096/fj.201700629R 10.1096/fj.201700629R 29066614 29066614
Renoprotective effect of erythropoietin via modulation of the STAT6/MAPK/NF-κB pathway in ischemia/reperfusion injury after renal transplantation. International journal of molecular medicine Jinhua Zhang, Daqiang Zhao, Ning Na, Heng Li, Bin Miao, Liangqing Hong, Zhengyu Huang, 41, 1, None, 2017-10-20, 10.3892/ijmm.2017.3204 10.3892/ijmm.2017.3204 29115389 PMC5746301
A STAT6 Inhibitor AS1517499 Reduces Preventive Effects of Apoptotic Cell Instillation on Bleomycin-Induced Lung Fibrosis by Suppressing PPARγ. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology Myeong-Joo Kim, Ye-Ji Lee, Young-So Yoon, Jae H Lim, Eun-Mi Park, Young H Chong, Jihee Lee Kang, 45, 5, None, 2018-02-28, 10.1159/000487877 10.1159/000487877 29510393 29510393

Filter data

Compound AS1517499
Experiment types ELISA, IVIS in vivo imaging, Immuinofluorescence, Immunofluorescence, RT-qPCR, Resazurin sodium salt, Tumor volume, Western Blot
Concentrations 10.00, 100.00, 20.00, 250.00
Cell lines 264.7 RAW, 4T1-luc, 4T1-luc (xenograft), alveolar macrophages, hBSMC, kidney, liver, lung tissue, macrophages
Organisms Homo sapiens, Mus musculus, Rattus norvegicus
Animal models BALB/c, Lewis and Brown Norway, c57BL/6
STAT proteins STAT6, p-STAT6, p-STAT6 (Y641)
Other Arg-1, CD36, Caspase-1, Caspase-3, Cd34, F4/80, GAPDH, IFNγ, IL-10, IL-4, Il-1β, Il-6, JAK3, JNK, MMR, Mmp-2, Mrc-1, PPARγ, Postn, RhoA, Ym-1, p-JAK3 (Y980/981), p-JNK, p-p38, p38, p65, α-tubulin, β-actin

Experiments

Compound Experiment type Investigated event Concentration Cell line Organism Animal model Stat protein Details
AS1517499 Western Blot Influence on protein activity in presence of IL-13 100.00 nM hBSMC Homo sapiens STAT6
AS1517499 Western Blot Influence on protein activity in presence of IL-13 100.00 nM hBSMC Homo sapiens
AS1517499 Western Blot Influence on protein activity in presence of IL-6 100.00 nM hBSMC Homo sapiens
AS1517499 Western Blot Influence on protin activity 10.00 nM 264.7 RAW Mus musculus p-STAT6
AS1517499 Western Blot Influence on protin activity 100.00 nM 264.7 RAW Mus musculus p-STAT6
AS1517499 Western Blot Influence on protin activity 250.00 nM 264.7 RAW Mus musculus p-STAT6
AS1517499 Western Blot Influence on protin activity 10.00 nM 264.7 RAW Mus musculus STAT6
AS1517499 Western Blot Influence on protin activity 100.00 nM 264.7 RAW Mus musculus STAT6
AS1517499 Western Blot Influence on protin activity 250.00 nM 264.7 RAW Mus musculus STAT6
AS1517499 Western Blot Influence on protin activity 10.00 nM 264.7 RAW Mus musculus
AS1517499 Western Blot Influence on protin activity 100.00 nM 264.7 RAW Mus musculus
AS1517499 Western Blot Influence on protin activity 250.00 nM 264.7 RAW Mus musculus
AS1517499 RT-qPCR Influence on macrophage differentiation 10.00 nM 264.7 RAW Mus musculus
AS1517499 RT-qPCR Influence on macrophage differentiation 100.00 nM 264.7 RAW Mus musculus
AS1517499 RT-qPCR Influence on macrophage differentiation 250.00 nM 264.7 RAW Mus musculus
AS1517499 RT-qPCR Influence on macrophage differentiation 10.00 nM 264.7 RAW Mus musculus
AS1517499 RT-qPCR Influence on macrophage differentiation 100.00 nM 264.7 RAW Mus musculus
AS1517499 RT-qPCR Influence on macrophage differentiation 250.00 nM 264.7 RAW Mus musculus
AS1517499 RT-qPCR Influence on macrophage differentiation 10.00 nM 264.7 RAW Mus musculus
AS1517499 RT-qPCR Influence on macrophage differentiation 100.00 nM 264.7 RAW Mus musculus
AS1517499 RT-qPCR Influence on macrophage differentiation 250.00 nM 264.7 RAW Mus musculus
AS1517499 RT-qPCR Influence on macrophage differentiation 10.00 nM 264.7 RAW Mus musculus
AS1517499 RT-qPCR Influence on macrophage differentiation 100.00 nM 264.7 RAW Mus musculus
AS1517499 RT-qPCR Influence on macrophage differentiation 250.00 nM 264.7 RAW Mus musculus
AS1517499 Resazurin sodium salt Influence on cell viability 100.00 nM 4T1-luc Mus musculus
AS1517499 Resazurin sodium salt Influence on cell viability 250.00 nM 4T1-luc Mus musculus
AS1517499 Tumor volume Influence on cell proliferation in tumor tissue 20.00 mg/kg 4T1-luc (xenograft) Mus musculus BALB/c
AS1517499 IVIS in vivo imaging Influence on cell proliferation in tumor tissue 20.00 mg/kg 4T1-luc (xenograft) Mus musculus BALB/c
AS1517499 IVIS in vivo imaging Influence on tumor metastasis 20.00 mg/kg liver Mus musculus BALB/c
AS1517499 RT-qPCR Influence on tumor progression 20.00 mg/kg macrophages Mus musculus BALB/c
AS1517499 RT-qPCR Influence on tumor progression 20.00 mg/kg macrophages Mus musculus BALB/c
AS1517499 RT-qPCR Influence on tumor progression 20.00 mg/kg macrophages Mus musculus BALB/c
AS1517499 RT-qPCR Influence on tumor progression 20.00 mg/kg liver Mus musculus BALB/c
AS1517499 RT-qPCR Influence on tumor progression 20.00 mg/kg liver Mus musculus BALB/c
AS1517499 RT-qPCR Influence on tumor progression 20.00 mg/kg liver Mus musculus BALB/c
AS1517499 RT-qPCR Influence on cytokine expression in transplanted organ 10.00 mg/kg kidney Rattus norvegicus Lewis and Brown Norway
AS1517499 RT-qPCR Influence on cytokine expression in transplanted organ 10.00 mg/kg kidney Rattus norvegicus Lewis and Brown Norway
AS1517499 RT-qPCR Influence on cytokine expression in transplanted organ 10.00 mg/kg kidney Rattus norvegicus Lewis and Brown Norway
AS1517499 ELISA Influence on cytokine expression in serum 10.00 mg/kg kidney Rattus norvegicus Lewis and Brown Norway
AS1517499 ELISA Influence on cytokine expression in serum 10.00 mg/kg kidney Rattus norvegicus Lewis and Brown Norway
AS1517499 ELISA Influence on cytokine expression in serum 10.00 mg/kg kidney Rattus norvegicus Lewis and Brown Norway
AS1517499 Western Blot Influence on protein activity in transplanted tissue 10.00 mg/kg kidney Rattus norvegicus Lewis and Brown Norway STAT6
AS1517499 Western Blot Influence on protein activity in transplanted tissue 10.00 mg/kg kidney Rattus norvegicus Lewis and Brown Norway
AS1517499 Western Blot Influence on protein activity in transplanted tissue 10.00 mg/kg kidney Rattus norvegicus Lewis and Brown Norway
AS1517499 Western Blot Influence on protein activity in transplanted tissue 10.00 mg/kg kidney Rattus norvegicus Lewis and Brown Norway
AS1517499 Western Blot Influence on protein activity in transplanted tissue 10.00 mg/kg kidney Rattus norvegicus Lewis and Brown Norway
AS1517499 Western Blot Influence on protein activity in transplanted tissue 10.00 mg/kg kidney Rattus norvegicus Lewis and Brown Norway
AS1517499 Western Blot Influence on protein activity in transplanted tissue 10.00 mg/kg kidney Rattus norvegicus Lewis and Brown Norway
AS1517499 Western Blot Influence on protein activity in transplanted tissue 10.00 mg/kg kidney Rattus norvegicus Lewis and Brown Norway
AS1517499 Western Blot Influence on protein activity in transplanted tissue 10.00 mg/kg kidney Rattus norvegicus Lewis and Brown Norway
AS1517499 Western Blot Influence on protein activity 2 days post-bleomycin treatment 10.00 mg/kg lung tissue Mus musculus c57BL/6 p-STAT6 (Y641)
AS1517499 Western Blot Influence on protein activity 2 days post-bleomycin treatment 10.00 mg/kg lung tissue Mus musculus c57BL/6 STAT6
AS1517499 Western Blot Influence on protein activity 2 days post-bleomycin treatment 10.00 mg/kg lung tissue Mus musculus c57BL/6
AS1517499 Western Blot Influence on protein activity 7 days post-bleomycin treatment 10.00 mg/kg lung tissue Mus musculus c57BL/6 p-STAT6 (Y641)
AS1517499 Western Blot Influence on protein activity 7 days post-bleomycin treatment 10.00 mg/kg lung tissue Mus musculus c57BL/6 STAT6
AS1517499 Western Blot Influence on protein activity 7 days post-bleomycin treatment 10.00 mg/kg lung tissue Mus musculus c57BL/6
AS1517499 Western Blot Influence on protein activity 14 days post-bleomycin treatment 10.00 mg/kg lung tissue Mus musculus c57BL/6 p-STAT6 (Y641)
AS1517499 Western Blot Influence on protein activity 14 days post-bleomycin treatment 10.00 mg/kg lung tissue Mus musculus c57BL/6 STAT6
AS1517499 Western Blot Influence on protein activity 14 days post-bleomycin treatment 10.00 mg/kg lung tissue Mus musculus c57BL/6
AS1517499 Western Blot Influence on protein activity 2 days post-bleomycin treatment 10.00 mg/kg lung tissue Mus musculus c57BL/6
AS1517499 Western Blot Influence on protein activity 2 days post-bleomycin treatment 10.00 mg/kg lung tissue Mus musculus c57BL/6
AS1517499 Western Blot Influence on protein activity 7 days post-bleomycin treatment 10.00 mg/kg lung tissue Mus musculus c57BL/6
AS1517499 Western Blot Influence on protein activity 14 days post-bleomycin treatment 10.00 mg/kg lung tissue Mus musculus c57BL/6
AS1517499 Western Blot Influence on protein activity 14 days post-bleomycin treatment 10.00 mg/kg lung tissue Mus musculus c57BL/6
AS1517499 Immuinofluorescence Influence on protein activity 7 days post-bleomycin treatment 10.00 mg/kg alveolar macrophages Mus musculus c57BL/6
AS1517499 Immuinofluorescence Influence on protein activity 2 days post-bleomycin treatment 10.00 mg/kg alveolar macrophages Mus musculus c57BL/6
AS1517499 RT-qPCR Influence on STAT6 dependent genes 10.00 mg/kg alveolar macrophages Mus musculus c57BL/6
AS1517499 RT-qPCR Influence on STAT6 dependent genes 10.00 mg/kg lung tissue Mus musculus c57BL/6
AS1517499 Western Blot Influence on STAT6 dependent proteins 10.00 mg/kg lung tissue Mus musculus c57BL/6
AS1517499 Western Blot Influence on STAT6 dependent proteins 10.00 mg/kg lung tissue Mus musculus c57BL/6
AS1517499 Immunofluorescence Influence on STAT6 dependent genes 10.00 mg/kg alveolar macrophages Mus musculus c57BL/6
AS1517499 RT-qPCR Influence on gene expression 2 days post-bleomycin treatment 10.00 mg/kg lung tissue Mus musculus c57BL/6
AS1517499 RT-qPCR Influence on gene expression 2 days post-bleomycin treatment 10.00 mg/kg alveolar macrophages Mus musculus c57BL/6
AS1517499 RT-qPCR Influence on gene expression 7 days post-bleomycin treatment 10.00 mg/kg lung tissue Mus musculus c57BL/6
AS1517499 RT-qPCR Influence on gene expression 7 days post-bleomycin treatment 10.00 mg/kg alveolar macrophages Mus musculus c57BL/6
AS1517499 RT-qPCR Influence on gene expression 14 days post-bleomycin treatment 10.00 mg/kg lung tissue Mus musculus c57BL/6
AS1517499 RT-qPCR Influence on gene expression 14 days post-bleomycin treatment 10.00 mg/kg alveolar macrophages Mus musculus c57BL/6
AS1517499 RT-qPCR Influence on gene expression 2 days post-bleomycin treatment 10.00 mg/kg lung tissue Mus musculus c57BL/6
AS1517499 RT-qPCR Influence on gene expression 2 days post-bleomycin treatment 10.00 mg/kg alveolar macrophages Mus musculus c57BL/6
AS1517499 RT-qPCR Influence on gene expression 7 days post-bleomycin treatment 10.00 mg/kg lung tissue Mus musculus c57BL/6
AS1517499 RT-qPCR Influence on gene expression 7 days post-bleomycin treatment 10.00 mg/kg alveolar macrophages Mus musculus c57BL/6
AS1517499 RT-qPCR Influence on gene expression 14 days post-bleomycin treatment 10.00 mg/kg lung tissue Mus musculus c57BL/6
AS1517499 RT-qPCR Influence on gene expression 14 days post-bleomycin treatment 10.00 mg/kg alveolar macrophages Mus musculus c57BL/6
AS1517499 Western Blot Influence on protein activity 2 days post-bleomycin treatment 10.00 mg/kg lung tissue Mus musculus c57BL/6
AS1517499 Western Blot Influence on protein activity 2 days post-bleomycin treatment 10.00 mg/kg lung tissue Mus musculus c57BL/6
AS1517499 Western Blot Influence on protein activity 7 days post-bleomycin treatment 10.00 mg/kg lung tissue Mus musculus c57BL/6
AS1517499 Western Blot Influence on protein activity 7 days post-bleomycin treatment 10.00 mg/kg lung tissue Mus musculus c57BL/6
AS1517499 Western Blot Influence on protein activity 14 days post-bleomycin treatment 10.00 mg/kg lung tissue Mus musculus c57BL/6
AS1517499 Western Blot Influence on protein activity 14 days post-bleomycin treatment 10.00 mg/kg lung tissue Mus musculus c57BL/6