| Withacnistin |
Influence on expression of proteins downstream target genes |
Western Blot |
5.00 µM |
MDA-MB-468 |
Homo sapiens |
|
p-STAT3 |
|
| Withacnistin |
Influence on expression of proteins downstream target genes |
Western Blot |
10.00 µM |
MDA-MB-468 |
Homo sapiens |
|
p-STAT3 |
|
| Withacnistin |
Influence on expression of proteins downstream target genes |
Western Blot |
3.00 µM |
MDA-MB-468 |
Homo sapiens |
|
STAT3 |
|
| Withacnistin |
Influence on expression of proteins downstream target genes |
Western Blot |
5.00 µM |
MDA-MB-468 |
Homo sapiens |
|
STAT3 |
|
| Withacnistin |
Influence on expression of proteins downstream target genes |
Western Blot |
10.00 µM |
MDA-MB-468 |
Homo sapiens |
|
STAT3 |
|
| Withacnistin |
Influence on expression of proteins downstream target genes |
Western Blot |
3.00 µM |
MDA-MB-468 |
Homo sapiens |
|
p-STAT5 |
|
| Withacnistin |
Influence on expression of proteins downstream target genes |
Western Blot |
5.00 µM |
MDA-MB-468 |
Homo sapiens |
|
p-STAT5 |
|
| Withacnistin |
Influence on expression of proteins downstream target genes |
Western Blot |
10.00 µM |
MDA-MB-468 |
Homo sapiens |
|
p-STAT5 |
|
| Withacnistin |
Influence on expression of proteins downstream target genes |
Western Blot |
3.00 µM |
MDA-MB-468 |
Homo sapiens |
|
STAT5 |
|
| Withacnistin |
Influence on expression of proteins downstream target genes |
Western Blot |
5.00 µM |
MDA-MB-468 |
Homo sapiens |
|
STAT5 |
|
| Withacnistin |
Influence on expression of proteins downstream target genes |
Western Blot |
10.00 µM |
MDA-MB-468 |
Homo sapiens |
|
STAT5 |
|
| Withacnistin |
Influence on expression of proteins downstream target genes |
Western Blot |
3.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
| Withacnistin |
Influence on expression of proteins downstream target genes |
Western Blot |
5.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
| Withacnistin |
Influence on expression of proteins downstream target genes |
Western Blot |
10.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
| Withacnistin |
Influence on expression of proteins downstream target genes |
Western Blot |
3.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
| Withacnistin |
Influence on expression of proteins downstream target genes |
Western Blot |
5.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
| Withacnistin |
Influence on expression of proteins downstream target genes |
Western Blot |
10.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
| Withacnistin |
Influence on expression of proteins downstream target genes |
Western Blot |
3.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
| Withacnistin |
Influence on expression of proteins downstream target genes |
Western Blot |
5.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
| Withacnistin |
Influence on expression of proteins downstream target genes |
Western Blot |
10.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
| Withacnistin |
Influence on expression of proteins downstream target genes |
Luciferase activity |
3.00 µM |
MDA-MB-468 pLucSRE |
Homo sapiens |
|
|
|
| Withacnistin |
Influence on expression of proteins downstream target genes |
Luciferase activity |
5.00 µM |
MDA-MB-468 pLucSRE |
Homo sapiens |
|
|
|
| Withacnistin |
Influence on expression of proteins downstream target genes |
Luciferase activity |
10.00 µM |
MDA-MB-468 pLucSRE |
Homo sapiens |
|
|
|
| Withacnistin |
Influence on expression of proteins downstream target genes |
Luciferase activity |
3.00 µM |
MDA-MB-468 pLucTKS3 |
Homo sapiens |
|
|
|
| Withacnistin |
Influence on expression of proteins downstream target genes |
Luciferase activity |
5.00 µM |
MDA-MB-468 pLucTKS3 |
Homo sapiens |
|
|
|
| Withacnistin |
Influence on expression of proteins downstream target genes |
Luciferase activity |
10.00 µM |
MDA-MB-468 pLucTKS3 |
Homo sapiens |
|
|
|
| Withacnistin |
Influence on cell apoptosis |
TUNEL |
0.10 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
| Withacnistin |
Influence on cell apoptosis |
TUNEL |
0.30 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
| Withacnistin |
Influence on cell apoptosis |
TUNEL |
1.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
| Withacnistin |
Influence on cell apoptosis |
TUNEL |
3.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
| Withacnistin |
Influence on cell apoptosis |
TUNEL |
10.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
| Withacnistin |
Influence on cell motility |
Invasion assay |
1.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
| Withacnistin |
Influence on cell motility |
Invasion assay |
3.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
| Withacnistin |
Influence on cell motility |
Invasion assay |
5.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
| Withacnistin |
Influence on cell motility |
Invasion assay |
10.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
| Withacnistin |
Influence on cell motility |
Colony formation assay |
1.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
| Withacnistin |
Influence on cell motility |
Colony formation assay |
3.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
| Withacnistin |
Influence on cell motility |
Colony formation assay |
5.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
| Withacnistin |
Influence on cell motility |
Colony formation assay |
10.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
| Withacnistin |
Influence on cell motility |
Colony formation assay |
1.00 µM |
A549 |
Homo sapiens |
|
|
|
| Withacnistin |
Influence on cell motility |
Colony formation assay |
3.00 µM |
A549 |
Homo sapiens |
|
|
|
| Withacnistin |
Influence on cell motility |
Colony formation assay |
5.00 µM |
A549 |
Homo sapiens |
|
|
|
| Withacnistin |
Influence on cell motility |
Colony formation assay |
10.00 µM |
A549 |
Homo sapiens |
|
|
|
| Withacnistin |
Influence on tumor growth |
Tumor volume |
20.00 mg/kg/day |
breast tumor tissue |
Mus musculus |
ErbB2 |
|
|
| Withacnistin |
Influence on protein activity in presence of EGF |
Western Blot |
10.00 µM |
MDA-MB-468 |
Homo sapiens |
|
p-STAT3 |
|
| Withacnistin |
Influence on protein activity in presence of EGF |
Western Blot |
10.00 µM |
MDA-MB-468 |
Homo sapiens |
|
STAT3 |
|
| Withacnistin |
Influence on protein activity in presence of EGF |
Western Blot |
10.00 µM |
MDA-MB-468 |
Homo sapiens |
|
p-STAT5 |
|
| Withacnistin |
Influence on protein activity in presence of EGF |
Western Blot |
10.00 µM |
MDA-MB-468 |
Homo sapiens |
|
STAT5 |
|
| Withacnistin |
Influence on protein activity in presence of EGF |
Western Blot |
10.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
| Withacnistin |
Influence on protein activity |
Co-immunoprecipitation |
10.00 µM |
MDA-MB-468 |
Homo sapiens |
|
IP:EGFR IB:STAT3 |
|
