| Tofacitinib (CP-690.550) |
Influence on arthritis development |
Arthritis score |
15.00 mg/kg/day |
|
Mus musculus |
DBA/1 |
|
|
| Tofacitinib (CP-690.550) |
Influence on cytokine levels in serum |
ELISA |
15.00 mg/kg/day |
|
Mus musculus |
DBA/1 |
|
|
| Tofacitinib (CP-690.550) |
Influence on cytokine levels in serum |
ELISA |
15.00 mg/kg/day |
|
Mus musculus |
DBA/1 |
|
|
| Tofacitinib (CP-690.550) |
Influence on EAE development |
Mean Clinical Score |
15.00 mg/kg/day |
|
Mus musculus |
DBA/1 |
|
|
| Tofacitinib (CP-690.550) |
Influence on cytokine levels in CNS |
Flow cytometry |
15.00 mg/kg/day |
|
Mus musculus |
DBA/1 |
|
|
| Tofacitinib (CP-690.550) |
Influence on Th differentiation |
[3H] thymidine incorporation |
10.00 nM |
Naïve CD4+ T |
Mus musculus |
c57BL/6 |
|
|
| Tofacitinib (CP-690.550) |
Influence on Th differentiation |
[3H] thymidine incorporation |
30.00 nM |
Naïve CD4+ T |
Mus musculus |
c57BL/6 |
|
|
| Tofacitinib (CP-690.550) |
Influence on Th differentiation |
[3H] thymidine incorporation |
100.00 nM |
Naïve CD4+ T |
Mus musculus |
c57BL/6 |
|
|
| Tofacitinib (CP-690.550) |
Influence on Th1 differentiation |
Intracellular staining |
10.00 nM |
Naïve CD4+ T |
Mus musculus |
c57BL/6 |
|
|
| Tofacitinib (CP-690.550) |
Influence on Th1 differentiation |
Intracellular staining |
50.00 nM |
Naïve CD4+ T |
Mus musculus |
c57BL/6 |
|
|
| Tofacitinib (CP-690.550) |
Influence on Th2 differentiation |
Intracellular staining |
10.00 nM |
Naïve CD4+ T |
Mus musculus |
c57BL/6 |
|
|
| Tofacitinib (CP-690.550) |
Influence on Th2 differentiation |
Intracellular staining |
50.00 nM |
Naïve CD4+ T |
Mus musculus |
c57BL/6 |
|
|
| Tofacitinib (CP-690.550) |
Influence on Th17 differentiation |
Intracellular staining |
10.00 nM |
Naïve CD4+ T |
Mus musculus |
c57BL/6 |
|
|
| Tofacitinib (CP-690.550) |
Influence on Th17 differentiation |
Intracellular staining |
50.00 nM |
Naïve CD4+ T |
Mus musculus |
c57BL/6 |
|
|
| Tofacitinib (CP-690.550) |
Influence on Th17 differentiation |
Intracellular staining |
10.00 nM |
Naïve CD4+ T |
Mus musculus |
c57BL/6 |
|
|
| Tofacitinib (CP-690.550) |
Influence on Th17 differentiation |
Intracellular staining |
100.00 nM |
Naïve CD4+ T |
Mus musculus |
c57BL/6 |
|
|
| Tofacitinib (CP-690.550) |
Influence on protein activity in presence of TGF-β and IL-6 |
Western Blot |
10.00 nM |
Naïve CD4+ T |
Mus musculus |
c57BL/6 |
|
|
| Tofacitinib (CP-690.550) |
Influence on protein activity in presence of TGF-β and IL-6 |
Western Blot |
30.00 nM |
Naïve CD4+ T |
Mus musculus |
c57BL/6 |
|
|
| Tofacitinib (CP-690.550) |
Influence on protein activity in presence of TGF-β and IL-6 |
Western Blot |
100.00 nM |
Naïve CD4+ T |
Mus musculus |
c57BL/6 |
|
|
| Tofacitinib (CP-690.550) |
Influence on protein activity in presence of TGF-β and IL-6 |
Western Blot |
10.00 nM |
Naïve CD4+ T |
Mus musculus |
c57BL/6 |
|
|
| Tofacitinib (CP-690.550) |
Influence on protein activity in presence of TGF-β and IL-6 |
Western Blot |
30.00 nM |
Naïve CD4+ T |
Mus musculus |
c57BL/6 |
|
|
| Tofacitinib (CP-690.550) |
Influence on protein activity in presence of TGF-β and IL-6 |
Western Blot |
100.00 nM |
Naïve CD4+ T |
Mus musculus |
c57BL/6 |
|
|
| Tofacitinib (CP-690.550) |
Influence on protein activity in presence of TGF-β and IL-6 |
Western Blot |
10.00 nM |
Naïve CD4+ T |
Mus musculus |
c57BL/6 |
p-STAT1 |
|
| Tofacitinib (CP-690.550) |
Influence on protein activity in presence of TGF-β and IL-6 |
Western Blot |
30.00 nM |
Naïve CD4+ T |
Mus musculus |
c57BL/6 |
p-STAT1 |
|
| Tofacitinib (CP-690.550) |
Influence on protein activity in presence of TGF-β and IL-6 |
Western Blot |
100.00 nM |
Naïve CD4+ T |
Mus musculus |
c57BL/6 |
p-STAT1 |
|
| Tofacitinib (CP-690.550) |
Influence on protein activity in presence of TGF-β and IL-6 |
Western Blot |
10.00 nM |
Naïve CD4+ T |
Mus musculus |
c57BL/6 |
STAT1 |
|
| Tofacitinib (CP-690.550) |
Influence on protein activity in presence of TGF-β and IL-6 |
Western Blot |
30.00 nM |
Naïve CD4+ T |
Mus musculus |
c57BL/6 |
STAT1 |
|
| Tofacitinib (CP-690.550) |
Influence on protein activity in presence of TGF-β and IL-6 |
Western Blot |
100.00 nM |
Naïve CD4+ T |
Mus musculus |
c57BL/6 |
STAT1 |
|
| Tofacitinib (CP-690.550) |
Influence on protein activity in presence of TGF-β and IL-6 |
Western Blot |
10.00 nM |
Naïve CD4+ T |
Mus musculus |
c57BL/6 |
p-STAT3 |
|
| Tofacitinib (CP-690.550) |
Influence on protein activity in presence of TGF-β and IL-6 |
Western Blot |
30.00 nM |
Naïve CD4+ T |
Mus musculus |
c57BL/6 |
p-STAT3 |
|
| Tofacitinib (CP-690.550) |
Influence on protein activity in presence of TGF-β and IL-6 |
Western Blot |
100.00 nM |
Naïve CD4+ T |
Mus musculus |
c57BL/6 |
p-STAT3 |
|
| Tofacitinib (CP-690.550) |
Influence on protein activity in presence of TGF-β and IL-6 |
Western Blot |
10.00 nM |
Naïve CD4+ T |
Mus musculus |
c57BL/6 |
STAT3 |
|
| Tofacitinib (CP-690.550) |
Influence on protein activity in presence of TGF-β and IL-6 |
Western Blot |
30.00 nM |
Naïve CD4+ T |
Mus musculus |
c57BL/6 |
STAT3 |
|
| Tofacitinib (CP-690.550) |
Influence on protein activity in presence of TGF-β and IL-6 |
Western Blot |
100.00 nM |
Naïve CD4+ T |
Mus musculus |
c57BL/6 |
STAT3 |
|
| Tofacitinib (CP-690.550) |
Influence on protein activity in presence of TGF-β and IL-6 |
Western Blot |
10.00 nM |
Naïve CD4+ T |
Mus musculus |
c57BL/6 |
p-STAT5 |
|
| Tofacitinib (CP-690.550) |
Influence on protein activity in presence of TGF-β and IL-6 |
Western Blot |
30.00 nM |
Naïve CD4+ T |
Mus musculus |
c57BL/6 |
p-STAT5 |
|
| Tofacitinib (CP-690.550) |
Influence on protein activity in presence of TGF-β and IL-6 |
Western Blot |
100.00 nM |
Naïve CD4+ T |
Mus musculus |
c57BL/6 |
p-STAT5 |
|
| Tofacitinib (CP-690.550) |
Influence on protein activity in presence of IFNγ |
Western Blot |
0.30 nM |
Naïve CD4+ T |
Mus musculus |
c57BL/6 |
p-STAT1 |
|
| Tofacitinib (CP-690.550) |
Influence on protein activity in presence of IFNγ |
Western Blot |
3.00 nM |
Naïve CD4+ T |
Mus musculus |
c57BL/6 |
p-STAT1 |
|
| Tofacitinib (CP-690.550) |
Influence on protein activity in presence of IFNγ |
Western Blot |
30.00 nM |
Naïve CD4+ T |
Mus musculus |
c57BL/6 |
p-STAT1 |
|
| Tofacitinib (CP-690.550) |
Influence on protein activity in presence of IFNγ |
Western Blot |
0.30 nM |
Naïve CD4+ T |
Mus musculus |
c57BL/6 |
STAT1 |
|
| Tofacitinib (CP-690.550) |
Influence on protein activity in presence of IFNγ |
Western Blot |
3.00 nM |
Naïve CD4+ T |
Mus musculus |
c57BL/6 |
STAT1 |
|
| Tofacitinib (CP-690.550) |
Influence on protein activity in presence of IFNγ |
Western Blot |
30.00 nM |
Naïve CD4+ T |
Mus musculus |
c57BL/6 |
STAT1 |
|
| Tofacitinib (CP-690.550) |
Influence on protein activity in presence of IL-4 |
Western Blot |
0.30 nM |
Naïve CD4+ T |
Mus musculus |
c57BL/6 |
p-STAT6 |
|
| Tofacitinib (CP-690.550) |
Influence on protein activity in presence of IL-4 |
Western Blot |
3.00 nM |
Naïve CD4+ T |
Mus musculus |
c57BL/6 |
p-STAT6 |
|
| Tofacitinib (CP-690.550) |
Influence on protein activity in presence of IL-4 |
Western Blot |
30.00 nM |
Naïve CD4+ T |
Mus musculus |
c57BL/6 |
p-STAT6 |
|
| Tofacitinib (CP-690.550) |
Influence on protein activity in presence of IL-4 |
Western Blot |
0.30 nM |
Naïve CD4+ T |
Mus musculus |
c57BL/6 |
STAT6 |
|
| Tofacitinib (CP-690.550) |
Influence on protein activity in presence of IL-4 |
Western Blot |
3.00 nM |
Naïve CD4+ T |
Mus musculus |
c57BL/6 |
STAT6 |
|
| Tofacitinib (CP-690.550) |
Influence on protein activity in presence of IL-4 |
Western Blot |
30.00 nM |
Naïve CD4+ T |
Mus musculus |
c57BL/6 |
STAT6 |
|
| Tofacitinib (CP-690.550) |
Influence on protein activity in presence of IL-2 |
Western Blot |
0.30 nM |
Naïve CD4+ T |
Mus musculus |
c57BL/6 |
p-STAT5 |
|
