| Tofacitinib (CP-690.550) |
Influence on Th differentiation |
[3H] thymidine incorporation |
100.00 nM |
Naïve CD4+ T |
Mus musculus |
c57BL/6 |
|
|
| Tofacitinib (CP-690.550) |
Influence on Th17 differentiation |
Intracellular staining |
100.00 nM |
Naïve CD4+ T |
Mus musculus |
c57BL/6 |
|
|
| Tofacitinib (CP-690.550) |
Influence on protein activity in presence of TGF-β and IL-6 |
Western Blot |
100.00 nM |
Naïve CD4+ T |
Mus musculus |
c57BL/6 |
|
|
| Tofacitinib (CP-690.550) |
Influence on protein activity in presence of TGF-β and IL-6 |
Western Blot |
100.00 nM |
Naïve CD4+ T |
Mus musculus |
c57BL/6 |
|
|
| Tofacitinib (CP-690.550) |
Influence on protein activity in presence of TGF-β and IL-6 |
Western Blot |
100.00 nM |
Naïve CD4+ T |
Mus musculus |
c57BL/6 |
p-STAT1 |
|
| Tofacitinib (CP-690.550) |
Influence on protein activity in presence of TGF-β and IL-6 |
Western Blot |
100.00 nM |
Naïve CD4+ T |
Mus musculus |
c57BL/6 |
STAT1 |
|
| Tofacitinib (CP-690.550) |
Influence on protein activity in presence of TGF-β and IL-6 |
Western Blot |
100.00 nM |
Naïve CD4+ T |
Mus musculus |
c57BL/6 |
p-STAT3 |
|
| Tofacitinib (CP-690.550) |
Influence on protein activity in presence of TGF-β and IL-6 |
Western Blot |
100.00 nM |
Naïve CD4+ T |
Mus musculus |
c57BL/6 |
STAT3 |
|
| Tofacitinib (CP-690.550) |
Influence on protein activity in presence of TGF-β and IL-6 |
Western Blot |
100.00 nM |
Naïve CD4+ T |
Mus musculus |
c57BL/6 |
p-STAT5 |
|
| Tofacitinib (CP-690.550) |
Influence on protein activity in presence of IL-6 |
Western Blot |
100.00 nM |
Naïve CD4+ T |
Mus musculus |
c57BL/6 |
p-STAT3 |
|
| Tofacitinib (CP-690.550) |
Influence on protein activity in presence of IL-6 |
Western Blot |
100.00 nM |
Naïve CD4+ T |
Mus musculus |
c57BL/6 |
STAT3 |
|
| Tofacitinib (CP-690.550) |
Influence on protein activity in transfecfected cells |
Western Blot |
100.00 nM |
HEK293T |
Homo sapiens |
|
p-STAT3 |
|
| Tofacitinib (CP-690.550) |
Influence on protein activity in transfecfected cells |
Western Blot |
100.00 nM |
HEK293T |
Homo sapiens |
|
|
|
| Tofacitinib (CP-690.550) |
Influence on protein acticity in presence of IL-6 |
Western Blot |
100.00 nM |
FLS |
Homo sapiens |
|
p-STAT1 |
|
| Tofacitinib (CP-690.550) |
Influence on protein acticity in presence of IL-6 |
Western Blot |
100.00 nM |
FLS |
Homo sapiens |
|
STAT1 |
|
| Tofacitinib (CP-690.550) |
Influence on protein acticity in presence of IL-6 |
Western Blot |
100.00 nM |
FLS |
Homo sapiens |
|
p-STAT3 |
|
| Tofacitinib (CP-690.550) |
Influence on protein acticity in presence of IL-6 |
Western Blot |
100.00 nM |
FLS |
Homo sapiens |
|
STAT3 |
|
| Tofacitinib (CP-690.550) |
Influence on protein acticity in presence of IL-6 |
Western Blot |
100.00 nM |
FLS |
Homo sapiens |
|
|
|
