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Experiments

Compound Investigated event Experiment type Concentration Cell line Organism Animal model Stat protein Details
STX-0119 Influence on protein activity Phosphorylation assay 5.00 µM SCC3 Homo sapiens p-STAT3
STX-0119 Influence on protein activity Phosphorylation assay 20.00 µM SCC3 Homo sapiens p-STAT3
STX-0119 Influence on protein activity Phosphorylation assay 9.00 µM U937 Homo sapiens p-STAT3
STX-0119 Influence on protein activity Phosphorylation assay 36.00 µM U937 Homo sapiens p-STAT3
STX-0119 Influence on protein activity Western Blot 2.00 µM SCC3 Homo sapiens p-STAT3
STX-0119 Influence on protein activity Western Blot 5.00 µM SCC3 Homo sapiens p-STAT3
STX-0119 Influence on protein activity Western Blot 10.00 µM SCC3 Homo sapiens p-STAT3
STX-0119 Influence on protein activity Western Blot 20.00 µM SCC3 Homo sapiens p-STAT3
STX-0119 Influence on dowstream target genes expression Western Blot 2.00 µM SCC3 Homo sapiens p-STAT3
STX-0119 Influence on dowstream target genes expression Western Blot 5.00 µM SCC3 Homo sapiens p-STAT3
STX-0119 Influence on dowstream target genes expression Western Blot 10.00 µM SCC3 Homo sapiens p-STAT3
STX-0119 Influence on dowstream target genes expression Western Blot 20.00 µM SCC3 Homo sapiens p-STAT3
STX-0119 Influence on protein activity in tumor tissue Western Blot 80.00 mg/kg SCC3 (xenograft) Mus musculus BALB/cA-nu/nu p-STAT3
STX-0119 Influence on protein activity in tumor tissue Western Blot 160.00 mg/kg SCC3 (xenograft) Mus musculus BALB/cA-nu/nu p-STAT3
STX-0119 Influence on protein activity in tumor tissue Immunostaining 160.00 mg/kg SCC3 (xenograft) Mus musculus BALB/cA-nu/nu p-STAT3
STX-0119 Influence on protein activity in precence of IFNα Western Blot 25.00 µM HMEC Homo sapiens p-STAT3
STX-0119 Influence on protein activity in precence of IFNα Western Blot 12.50 µM HMEC Homo sapiens p-STAT3
STX-0119 Influence on protein activity in precence of IFNα Western Blot 6.25 µM HMEC Homo sapiens p-STAT3
STX-0119 Influence on protein activity Western Blot 10.00 µM MDA-MB-468 Homo sapiens p-STAT3 (Y705)
STX-0119 Influence on protein activity Western Blot 20.00 µM MDA-MB-468 Homo sapiens p-STAT3 (Y705)
STX-0119 Influence on protein activity Western Blot 50.00 µM MDA-MB-468 Homo sapiens p-STAT3 (Y705)
STX-0119 Influence on protein translocation Western Blot 20.00 µM SCC3 Homo sapiens p-STAT3 (nucleus)
STX-0119 Influence on protein translocation Western Blot 20.00 µM SCC3 Homo sapiens p-STAT3 (cytoplasm)