| STX-0119 |
Influence on protein activity |
Phosphorylation assay |
5.00 µM |
SCC3 |
Homo sapiens |
|
p-STAT3 |
|
| STX-0119 |
Influence on protein activity |
Phosphorylation assay |
20.00 µM |
SCC3 |
Homo sapiens |
|
p-STAT3 |
|
| STX-0119 |
Influence on protein activity |
Phosphorylation assay |
9.00 µM |
U937 |
Homo sapiens |
|
p-STAT3 |
|
| STX-0119 |
Influence on protein activity |
Phosphorylation assay |
36.00 µM |
U937 |
Homo sapiens |
|
p-STAT3 |
|
| STX-0119 |
Influence on protein activity |
Western Blot |
2.00 µM |
SCC3 |
Homo sapiens |
|
p-STAT3 |
|
| STX-0119 |
Influence on protein activity |
Western Blot |
5.00 µM |
SCC3 |
Homo sapiens |
|
p-STAT3 |
|
| STX-0119 |
Influence on protein activity |
Western Blot |
10.00 µM |
SCC3 |
Homo sapiens |
|
p-STAT3 |
|
| STX-0119 |
Influence on protein activity |
Western Blot |
20.00 µM |
SCC3 |
Homo sapiens |
|
p-STAT3 |
|
| STX-0119 |
Influence on dowstream target genes expression |
Western Blot |
2.00 µM |
SCC3 |
Homo sapiens |
|
p-STAT3 |
|
| STX-0119 |
Influence on dowstream target genes expression |
Western Blot |
5.00 µM |
SCC3 |
Homo sapiens |
|
p-STAT3 |
|
| STX-0119 |
Influence on dowstream target genes expression |
Western Blot |
10.00 µM |
SCC3 |
Homo sapiens |
|
p-STAT3 |
|
| STX-0119 |
Influence on dowstream target genes expression |
Western Blot |
20.00 µM |
SCC3 |
Homo sapiens |
|
p-STAT3 |
|
| STX-0119 |
Influence on protein activity in tumor tissue |
Western Blot |
80.00 mg/kg |
SCC3 (xenograft) |
Mus musculus |
BALB/cA-nu/nu |
p-STAT3 |
|
| STX-0119 |
Influence on protein activity in tumor tissue |
Western Blot |
160.00 mg/kg |
SCC3 (xenograft) |
Mus musculus |
BALB/cA-nu/nu |
p-STAT3 |
|
| STX-0119 |
Influence on protein activity in tumor tissue |
Immunostaining |
160.00 mg/kg |
SCC3 (xenograft) |
Mus musculus |
BALB/cA-nu/nu |
p-STAT3 |
|
| STX-0119 |
Influence on protein activity in precence of IFNα |
Western Blot |
25.00 µM |
HMEC |
Homo sapiens |
|
p-STAT3 |
|
| STX-0119 |
Influence on protein activity in precence of IFNα |
Western Blot |
12.50 µM |
HMEC |
Homo sapiens |
|
p-STAT3 |
|
| STX-0119 |
Influence on protein activity in precence of IFNα |
Western Blot |
6.25 µM |
HMEC |
Homo sapiens |
|
p-STAT3 |
|
| STX-0119 |
Influence on protein activity |
Western Blot |
2.00 µM |
SCC3 |
Homo sapiens |
|
STAT3 |
|
| STX-0119 |
Influence on protein activity |
Western Blot |
5.00 µM |
SCC3 |
Homo sapiens |
|
STAT3 |
|
| STX-0119 |
Influence on protein activity |
Western Blot |
10.00 µM |
SCC3 |
Homo sapiens |
|
STAT3 |
|
| STX-0119 |
Influence on protein activity |
Western Blot |
20.00 µM |
SCC3 |
Homo sapiens |
|
STAT3 |
|
| STX-0119 |
Influence on dowstream target genes expression |
Western Blot |
2.00 µM |
SCC3 |
Homo sapiens |
|
STAT3 |
|
| STX-0119 |
Influence on dowstream target genes expression |
Western Blot |
5.00 µM |
SCC3 |
Homo sapiens |
|
STAT3 |
|
| STX-0119 |
Influence on dowstream target genes expression |
Western Blot |
10.00 µM |
SCC3 |
Homo sapiens |
|
STAT3 |
|
| STX-0119 |
Influence on dowstream target genes expression |
Western Blot |
20.00 µM |
SCC3 |
Homo sapiens |
|
STAT3 |
|
| STX-0119 |
Influence on protein activity in tumor tissue |
Western Blot |
80.00 mg/kg |
SCC3 (xenograft) |
Mus musculus |
BALB/cA-nu/nu |
STAT3 |
|
| STX-0119 |
Influence on protein activity in tumor tissue |
Western Blot |
160.00 mg/kg |
SCC3 (xenograft) |
Mus musculus |
BALB/cA-nu/nu |
STAT3 |
|
| STX-0119 |
Influence on protein activity in tumor tissue |
Immunostaining |
160.00 mg/kg |
SCC3 (xenograft) |
Mus musculus |
BALB/cA-nu/nu |
STAT3 |
|
| STX-0119 |
Influence on protein activity |
Chromatin immunoprecipitation |
10.00 µM |
MDA-MB-468 |
Homo sapiens |
|
STAT3 |
|
| STX-0119 |
Influence on protein activity |
Chromatin immunoprecipitation |
20.00 µM |
MDA-MB-468 |
Homo sapiens |
|
STAT3 |
|
| STX-0119 |
Influence on protein activity |
Chromatin immunoprecipitation |
50.00 µM |
MDA-MB-468 |
Homo sapiens |
|
STAT3 |
|
| STX-0119 |
Influence on protein activity |
Western Blot |
10.00 µM |
MDA-MB-468 |
Homo sapiens |
|
STAT3 |
|
| STX-0119 |
Influence on protein activity |
Western Blot |
20.00 µM |
MDA-MB-468 |
Homo sapiens |
|
STAT3 |
|
| STX-0119 |
Influence on protein activity |
Western Blot |
50.00 µM |
MDA-MB-468 |
Homo sapiens |
|
STAT3 |
|
| STX-0119 |
Influence on protein activity in precence of IFNα |
Western Blot |
25.00 µM |
HMEC |
Homo sapiens |
|
STAT3 |
|
| STX-0119 |
Influence on protein activity in precence of IFNα |
Western Blot |
12.50 µM |
HMEC |
Homo sapiens |
|
STAT3 |
|
| STX-0119 |
Influence on protein activity in precence of IFNα |
Western Blot |
6.25 µM |
HMEC |
Homo sapiens |
|
STAT3 |
|
| STX-0119 |
Influence on protein activity |
Western Blot |
10.00 µM |
MDA-MB-468 |
Homo sapiens |
|
p-STAT3 (Y705) |
|
| STX-0119 |
Influence on protein activity |
Western Blot |
20.00 µM |
MDA-MB-468 |
Homo sapiens |
|
p-STAT3 (Y705) |
|
| STX-0119 |
Influence on protein activity |
Western Blot |
50.00 µM |
MDA-MB-468 |
Homo sapiens |
|
p-STAT3 (Y705) |
|
| STX-0119 |
Influence on protein activity |
FRET |
10.00 µM |
HEK293 |
Homo sapiens |
|
STAT3-YFP |
|
| STX-0119 |
Influence on protein activity |
FRET |
20.00 µM |
HEK293 |
Homo sapiens |
|
STAT3-YFP |
|
| STX-0119 |
Influence on protein activity |
FRET |
50.00 µM |
HEK293 |
Homo sapiens |
|
STAT3-YFP |
|
| STX-0119 |
Influence on protein translocation |
Western Blot |
20.00 µM |
SCC3 |
Homo sapiens |
|
p-STAT3 (nucleus) |
|
| STX-0119 |
Influence on protein translocation |
Western Blot |
20.00 µM |
SCC3 |
Homo sapiens |
|
p-STAT3 (cytoplasm) |
|
| STX-0119 |
Influence on protein translocation |
Western Blot |
20.00 µM |
SCC3 |
Homo sapiens |
|
STAT3 (nucelus) |
|
| STX-0119 |
Influence on protein translocation |
Western Blot |
20.00 µM |
SCC3 |
Homo sapiens |
|
STAT3 (cytoplam) |
|
| STX-0119 |
Influence on protein activity |
FRET |
10.00 µM |
HEK293 |
Homo sapiens |
|
STAT3-CFP |
|
| STX-0119 |
Influence on protein activity |
FRET |
20.00 µM |
HEK293 |
Homo sapiens |
|
STAT3-CFP |
|
