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Experiments

Compound Investigated event Experiment type Concentration Cell line Organism Animal model Stat protein Details
S3I-M2001 Influence on protein activity Western Blot 100.00 µM NIH 3T3/v-Src Mus musculus p-STAT3
S3I-M2001 Influence on protein activity Western Blot 100.00 µM MDA-MB-435 Homo sapiens p-STAT3
S3I-M2001 Influence on protein activity Western Blot 100.00 µM NIH 3T3/v-Src Mus musculus STAT3
S3I-M2001 Influence on protein activity Western Blot 100.00 µM MDA-MB-435 Homo sapiens STAT3
S3I-M2001 Influence on protein translocation Immunofluorescce 100.00 µM NIH3T3/hEGFR Mus musculus STAT3
S3I-M2001 Influence on protein translocation Immunofluorescce 300.00 µM NIH3T3/v-Src/Stat3-YFP Mus musculus STAT3
S3I-M2001 Influence on protein translocation Immunofluorescce 300.00 µM NIH3T3/v-Src/GFP Mus musculus STAT3
S3I-M2001 Influence on protein activity Western Blot 100.00 µM NIH3T3/v-Src/Stat3-YFP Mus musculus STAT3
S3I-M2001 Influence on protein aggregation into perinuclear aggresomes Immunofluorescce 100.00 µM NIH3T3/v- Src Mus musculus STAT3
S3I-M2001 Influence on protein activity in tumor tissue Western Blot 5.00 mg/kg MDA-MB-231 (xenograft) Mus musculus athymic nude mice STAT3
S3I-M2001 Influence on protein activity in tumor tissue Western Blot 5.00 mg/kg MDA-MB-231 (xenograft) Mus musculus athymic nude mice p-STAT3(Y705)
S3I-M2001 Influence on protein binding to DNA EMSA 0.30 µM Sf-9 Spodoptera frugiperda STAT3:STAT3
S3I-M2001 Influence on protein binding to DNA EMSA 1.00 µM Sf-9 Spodoptera frugiperda STAT3:STAT3
S3I-M2001 Influence on protein binding to DNA EMSA 10.00 µM Sf-9 Spodoptera frugiperda STAT3:STAT3
S3I-M2001 Influence on protein binding to DNA EMSA 30.00 µM Sf-9 Spodoptera frugiperda STAT3:STAT3
S3I-M2001 Influence on protein binding to DNA EMSA 100.00 µM Sf-9 Spodoptera frugiperda STAT3:STAT3
S3I-M2001 Influence on protein binding to DNA EMSA 300.00 µM Sf-9 Spodoptera frugiperda STAT3:STAT3
S3I-M2001 Influence on protein binding to DNA EMSA 500.00 µM Sf-9 Spodoptera frugiperda STAT3:STAT3
S3I-M2001 Influence on protein binding to DNA EMSA 10.00 µM NIH 3T3/v-Src Mus musculus STAT3:STAT3
S3I-M2001 Influence on protein binding to DNA EMSA 30.00 µM NIH 3T3/v-Src Mus musculus STAT3:STAT3
S3I-M2001 Influence on protein binding to DNA EMSA 100.00 µM NIH 3T3/v-Src Mus musculus STAT3:STAT3
S3I-M2001 Influence on protein binding to DNA EMSA 300.00 µM NIH 3T3/v-Src Mus musculus STAT3:STAT3
S3I-M2001 Influence on protein binding to DNA EMSA 10.00 µM MDA-MB-231 Homo sapiens STAT3:STAT3
S3I-M2001 Influence on protein binding to DNA EMSA 30.00 µM MDA-MB-231 Homo sapiens STAT3:STAT3
S3I-M2001 Influence on protein binding to DNA EMSA 100.00 µM MDA-MB-231 Homo sapiens STAT3:STAT3
S3I-M2001 Influence on protein binding to DNA EMSA 300.00 µM MDA-MB-231 Homo sapiens STAT3:STAT3
S3I-M2001 Influence on protein binding to DNA EMSA 100.00 µM NIH 3T3/hEGFR Mus musculus STAT3:STAT3
S3I-M2001 Influence on protein activity EMSA 30.00 µM NIH 3T3 Mus musculus STAT3:STAT3
S3I-M2001 Influence on protein activity EMSA 100.00 µM NIH 3T3 Mus musculus STAT3:STAT3
S3I-M2001 Influence on protein activity EMSA 300.00 µM NIH 3T3 Mus musculus STAT3:STAT3
S3I-M2001 Influence on protein activity EMSA 800.00 µM NIH 3T3 Mus musculus STAT3:STAT3
S3I-M2001 Influence on DNA binding in tumor EMSA 5.00 mg/kg MDA-MB-231 (xenograft) Mus musculus athymic nude mice STAT3:STAT3
S3I-M2001 Influence on protein activity EMSA 30.00 µM NIH 3T3 Mus musculus STAT1:STAT3
S3I-M2001 Influence on protein activity EMSA 100.00 µM NIH 3T3 Mus musculus STAT1:STAT3
S3I-M2001 Influence on protein activity EMSA 300.00 µM NIH 3T3 Mus musculus STAT1:STAT3
S3I-M2001 Influence on protein activity EMSA 800.00 µM NIH 3T3 Mus musculus STAT1:STAT3
S3I-M2001 Influence on protein binding to DNA EMSA 0.30 µM Sf-9 Spodoptera frugiperda STAT3:STAT1
S3I-M2001 Influence on protein binding to DNA EMSA 1.00 µM Sf-9 Spodoptera frugiperda STAT3:STAT1
S3I-M2001 Influence on protein binding to DNA EMSA 10.00 µM Sf-9 Spodoptera frugiperda STAT3:STAT1
S3I-M2001 Influence on protein binding to DNA EMSA 30.00 µM Sf-9 Spodoptera frugiperda STAT3:STAT1
S3I-M2001 Influence on protein binding to DNA EMSA 100.00 µM Sf-9 Spodoptera frugiperda STAT3:STAT1
S3I-M2001 Influence on protein binding to DNA EMSA 300.00 µM Sf-9 Spodoptera frugiperda STAT3:STAT1
S3I-M2001 Influence on protein binding to DNA EMSA 500.00 µM Sf-9 Spodoptera frugiperda STAT3:STAT1
S3I-M2001 Influence on protein binding to DNA EMSA 100.00 µM NIH 3T3/hEGFR Mus musculus STAT3:STAT1