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Experiments

Compound Investigated event Experiment type Concentration Cell line Organism Animal model Stat protein Details
S3I-M2001 Influence on cell proliferation Colony formation assay 30.00 µM NIH3T3/v-Src Mus musculus
S3I-M2001 Influence on cell proliferation Colony formation assay 100.00 µM NIH3T3/v-Src Mus musculus
S3I-M2001 Influence on cell proliferation Colony formation assay 30.00 µM NIH3T3/v-Ras Mus musculus
S3I-M2001 Influence on cell proliferation Colony formation assay 100.00 µM NIH3T3/v-Ras Mus musculus
S3I-M2001 Influence on DNA TUNEL 50.00 µM NIH3T3 Mus musculus
S3I-M2001 Influence on DNA TUNEL 50.00 µM NIH3T3/v-Src Mus musculus
S3I-M2001 Influence on DNA TUNEL 50.00 µM MCF-10A Mus musculus
S3I-M2001 Influence on apoptosis Flow cytometry 50.00 µM 3T3/v-Src/ pcDNA3 Mus musculus
S3I-M2001 Influence on apoptosis Flow cytometry 50.00 µM 3T3/v-Src/ ST3-SH2 Mus musculus
S3I-M2001 Influence on apoptosis Flow cytometry 50.00 µM 3T3/v-Src Mus musculus
S3I-M2001 Influence on apoptosis Western Blot 50.00 µM NIH3T3/v-Src Mus musculus
S3I-M2001 Influence on apoptosis Western Blot 50.00 µM NIH3T3/v-Src Mus musculus
S3I-M2001 Influence on cell motility Migration assay 100.00 µM NIH3T3/v-Src Mus musculus
S3I-M2001 Influence on tumor growth Tumor volume 5.00 mg/kg MDA-MB-231 (xenograft) Mus musculus athymic nude mice
S3I-M2001 Influence on tumor growth Tumor volume 10.00 mg/kg MDA-MB-231 (xenograft) Mus musculus athymic nude mice
S3I-M2001 Influence on tumor growth Tumor volume 20.00 mg/kg MDA-MB-231 (xenograft) Mus musculus athymic nude mice
S3I-M2001 Influence on DNA binding in tumor EMSA 5.00 mg/kg MDA-MB-231 (xenograft) Mus musculus athymic nude mice STAT3:STAT3
S3I-M2001 Influence on protein activity in tumor tissue Western Blot 5.00 mg/kg MDA-MB-231 (xenograft) Mus musculus athymic nude mice STAT3
S3I-M2001 Influence on protein activity in tumor tissue Western Blot 5.00 mg/kg MDA-MB-231 (xenograft) Mus musculus athymic nude mice p-STAT3(Y705)