| Ponatinib |
Influence on protein activity in presence of IL-6 |
Luciferase activity |
10.00 µM |
DLD-1 |
Homo sapiens |
|
|
|
| Ponatinib |
Influence on protein activity in presence of EGF |
Luciferase activity |
10.00 µM |
DIFI |
Homo sapiens |
|
|
|
| Ponatinib |
Influence on protein activity in presence of IL-6 |
Western Blot |
10.00 µM |
DLD-1 |
Homo sapiens |
|
p-STAT3 |
|
| Ponatinib |
Influence on protein activity in presence of IL-6 |
Western Blot |
10.00 µM |
DLD-1 |
Homo sapiens |
|
STAT3 |
|
| Ponatinib |
Influence on protein activity in presence of IL-6 |
Western Blot |
10.00 µM |
DLD-1 |
Homo sapiens |
|
|
|
| Ponatinib |
Influence on tumor growth |
Tumor volume |
10.00 mg/kg |
DLD-1 (xenograft) |
Mus musculus |
BALB/c |
|
|
| Ponatinib |
Influence on tumor growth |
Tumor volume |
10.00 mg/kg |
SW48 (xenograft) |
Mus musculus |
BALB/c |
|
|
| Ponatinib |
Influence on tumor growth |
Tumor weight |
10.00 mg/kg |
DLD-1 (xenograft) |
Mus musculus |
BALB/c |
|
|
| Ponatinib |
Influence on tumor growth |
Tumor weight |
10.00 mg/kg |
SW48 (xenograft) |
Mus musculus |
BALB/c |
|
|
| Ponatinib |
Influence on protein activity in tumor tissue |
Immunohistochemistry |
10.00 mg/kg |
DLD-1 (xenograft) |
Mus musculus |
BALB/c |
p-STAT3 |
|
| Ponatinib |
Influence on protein activity in tumor tissue |
Immunohistochemistry |
10.00 mg/kg |
SW48 (xenograft) |
Mus musculus |
BALB/c |
p-STAT3 |
|
| Ponatinib |
Influence on cell proliferation |
WST-8 |
10.00 µM |
IMR-32 |
Homo sapiens |
|
|
|
| Ponatinib |
Influence on cell proliferation |
WST-8 |
10.00 µM |
NGP |
Homo sapiens |
|
|
|
| Ponatinib |
Influence on cell proliferation |
WST-8 |
10.00 µM |
NB-19 |
Homo sapiens |
|
|
|
| Ponatinib |
Influence on cell proliferation |
WST-8 |
10.00 µM |
SK-N-AS |
Homo sapiens |
|
|
|
| Ponatinib |
Influence on cell proliferation |
WST-8 |
10.00 µM |
SH-SY5Y |
Homo sapiens |
|
|
|
| Ponatinib |
Influence on cell proliferation |
WST-8 |
10.00 µM |
LA-N6 |
Homo sapiens |
|
|
|
| Ponatinib |
Influence on protein activity |
Western Blot |
10.00 µM |
IMR-32 |
Homo sapiens |
|
|
|
| Ponatinib |
Influence on protein activity |
Western Blot |
10.00 µM |
IMR-32 |
Homo sapiens |
|
|
|
| Ponatinib |
Influence on protein activity |
Western Blot |
10.00 µM |
IMR-32 |
Homo sapiens |
|
|
|
| Ponatinib |
Influence on protein activity |
Western Blot |
10.00 µM |
IMR-32 |
Homo sapiens |
|
|
|
| Ponatinib |
Influence on protein activity |
Western Blot |
10.00 µM |
IMR-32 |
Homo sapiens |
|
|
|
| Ponatinib |
Influence on protein activity |
Western Blot |
10.00 µM |
IMR-32 |
Homo sapiens |
|
|
|
| Ponatinib |
Influence on protein activity |
Western Blot |
10.00 µM |
IMR-32 |
Homo sapiens |
|
|
|
| Ponatinib |
Influence on protein activity |
Western Blot |
10.00 µM |
IMR-32 |
Homo sapiens |
|
|
|
| Ponatinib |
Influence on protein activity |
Western Blot |
10.00 µM |
IMR-32 |
Homo sapiens |
|
p-STAT3 (Y705) |
|
| Ponatinib |
Influence on protein activity |
Western Blot |
10.00 µM |
IMR-32 |
Homo sapiens |
|
STAT3 |
|
| Ponatinib |
Influence on protein activity |
Western Blot |
10.00 µM |
IMR-32 |
Homo sapiens |
|
|
|
| Ponatinib |
Influence on protein activity |
Western Blot |
10.00 µM |
NGP |
Homo sapiens |
|
|
|
| Ponatinib |
Influence on protein activity |
Western Blot |
10.00 µM |
NGP |
Homo sapiens |
|
|
|
| Ponatinib |
Influence on protein activity |
Western Blot |
10.00 µM |
NGP |
Homo sapiens |
|
|
|
| Ponatinib |
Influence on protein activity |
Western Blot |
10.00 µM |
NGP |
Homo sapiens |
|
|
|
| Ponatinib |
Influence on protein activity |
Western Blot |
10.00 µM |
NGP |
Homo sapiens |
|
|
|
| Ponatinib |
Influence on protein activity |
Western Blot |
10.00 µM |
NGP |
Homo sapiens |
|
|
|
| Ponatinib |
Influence on protein activity |
Western Blot |
10.00 µM |
NGP |
Homo sapiens |
|
|
|
| Ponatinib |
Influence on protein activity |
Western Blot |
10.00 µM |
NGP |
Homo sapiens |
|
|
|
| Ponatinib |
Influence on protein activity |
Western Blot |
10.00 µM |
NGP |
Homo sapiens |
|
p-STAT3 (Y705) |
|
| Ponatinib |
Influence on protein activity |
Western Blot |
10.00 µM |
NGP |
Homo sapiens |
|
STAT3 |
|
| Ponatinib |
Influence on protein activity |
Western Blot |
10.00 µM |
NGP |
Homo sapiens |
|
|
|
| Ponatinib |
Influence on protein activity |
Western Blot |
10.00 µM |
NB-19 |
Homo sapiens |
|
|
|
| Ponatinib |
Influence on protein activity |
Western Blot |
10.00 µM |
NB-19 |
Homo sapiens |
|
|
|
| Ponatinib |
Influence on protein activity |
Western Blot |
10.00 µM |
NB-19 |
Homo sapiens |
|
|
|
| Ponatinib |
Influence on protein activity |
Western Blot |
10.00 µM |
NB-19 |
Homo sapiens |
|
|
|
| Ponatinib |
Influence on protein activity |
Western Blot |
10.00 µM |
NB-19 |
Homo sapiens |
|
|
|
| Ponatinib |
Influence on protein activity |
Western Blot |
10.00 µM |
NB-19 |
Homo sapiens |
|
|
|
| Ponatinib |
Influence on protein activity |
Western Blot |
10.00 µM |
NB-19 |
Homo sapiens |
|
|
|
| Ponatinib |
Influence on protein activity |
Western Blot |
10.00 µM |
NB-19 |
Homo sapiens |
|
|
|
| Ponatinib |
Influence on protein activity |
Western Blot |
10.00 µM |
NB-19 |
Homo sapiens |
|
p-STAT3 (Y705) |
|
| Ponatinib |
Influence on protein activity |
Western Blot |
10.00 µM |
NB-19 |
Homo sapiens |
|
STAT3 |
|
| Ponatinib |
Influence on protein activity |
Western Blot |
10.00 µM |
NB-19 |
Homo sapiens |
|
|
|
