| Ponatinib |
Influence on protein activity in presence of IL-6 |
Luciferase activity |
10.00 µM |
DLD-1 |
Homo sapiens |
|
|
|
| Ponatinib |
Influence on protein activity in presence of IL-11 |
Western Blot |
0.01 µM |
DLD-1 |
Homo sapiens |
|
p-STAT3 |
|
| Ponatinib |
Influence on protein activity in presence of IL-11 |
Western Blot |
0.10 µM |
DLD-1 |
Homo sapiens |
|
p-STAT3 |
|
| Ponatinib |
Influence on protein activity in presence of IL-11 |
Western Blot |
1.00 µM |
DLD-1 |
Homo sapiens |
|
p-STAT3 |
|
| Ponatinib |
Influence on protein activity in presence of IL-11 |
Western Blot |
0.01 µM |
DLD-1 |
Homo sapiens |
|
STAT3 |
|
| Ponatinib |
Influence on protein activity in presence of IL-11 |
Western Blot |
0.10 µM |
DLD-1 |
Homo sapiens |
|
STAT3 |
|
| Ponatinib |
Influence on protein activity in presence of IL-11 |
Western Blot |
1.00 µM |
DLD-1 |
Homo sapiens |
|
STAT3 |
|
| Ponatinib |
Influence on protein activity in presence of IL-11 |
Western Blot |
0.01 µM |
DLD-1 |
Homo sapiens |
|
|
|
| Ponatinib |
Influence on protein activity in presence of IL-11 |
Western Blot |
0.10 µM |
DLD-1 |
Homo sapiens |
|
|
|
| Ponatinib |
Influence on protein activity in presence of IL-11 |
Western Blot |
1.00 µM |
DLD-1 |
Homo sapiens |
|
|
|
| Ponatinib |
Influence on protein activity in presence of IL-6 |
Western Blot |
1.00 µM |
DLD-1 |
Homo sapiens |
|
p-STAT3 |
|
| Ponatinib |
Influence on protein activity in presence of IL-6 |
Western Blot |
10.00 µM |
DLD-1 |
Homo sapiens |
|
p-STAT3 |
|
| Ponatinib |
Influence on protein activity in presence of IL-6 |
Western Blot |
1.00 µM |
DLD-1 |
Homo sapiens |
|
STAT3 |
|
| Ponatinib |
Influence on protein activity in presence of IL-6 |
Western Blot |
10.00 µM |
DLD-1 |
Homo sapiens |
|
STAT3 |
|
| Ponatinib |
Influence on protein activity in presence of IL-6 |
Western Blot |
1.00 µM |
DLD-1 |
Homo sapiens |
|
|
|
| Ponatinib |
Influence on protein activity in presence of IL-6 |
Western Blot |
10.00 µM |
DLD-1 |
Homo sapiens |
|
|
|
| Ponatinib |
Influence on protein translocation in presence of IL-11 |
Fluorescent staining |
0.10 µM |
DLD-1 |
Homo sapiens |
|
STAT3 |
|
| Ponatinib |
Influence on protein translocation in presence of IL-11 |
Fluorescent staining |
1.00 µM |
DLD-1 |
Homo sapiens |
|
STAT3 |
|
| Ponatinib |
Influence on gene expression |
RT-qPCR |
0.10 µM |
DLD-1 |
Homo sapiens |
|
|
|
| Ponatinib |
Influence on gene expression |
RT-qPCR |
0.50 µM |
DLD-1 |
Homo sapiens |
|
|
|
| Ponatinib |
Influence on gene expression |
RT-qPCR |
1.00 µM |
DLD-1 |
Homo sapiens |
|
|
|
| Ponatinib |
Influence on protein activity in presence of IL-11 |
Western Blot |
1.00 µM |
DLD-1 |
Homo sapiens |
|
|
|
| Ponatinib |
Influence on protein activity in presence of IL-11 |
Western Blot |
1.00 µM |
DLD-1 |
Homo sapiens |
|
|
|
| Ponatinib |
Influence on cell proliferation |
Cell Titer Glo assay |
1.00 µM |
DLD-1 |
Homo sapiens |
|
|
|
| Ponatinib |
Influence on cell migration |
Wound healing assay |
1.00 µM |
DLD-1 |
Homo sapiens |
|
|
|
| Ponatinib |
Influence on cell migration |
Wound healing assay |
0.10 µM |
DLD-1 |
Homo sapiens |
|
|
|
| Ponatinib |
Influence on cell migration |
Wound healing assay |
0.50 µM |
DLD-1 |
Homo sapiens |
|
|
|
| Ponatinib |
Influence on tumor growth |
Tumor volume |
10.00 mg/kg |
DLD-1 (xenograft) |
Mus musculus |
BALB/c |
|
|
| Ponatinib |
Influence on tumor growth |
Tumor volume |
30.00 mg/kg |
DLD-1 (xenograft) |
Mus musculus |
BALB/c |
|
|
| Ponatinib |
Influence on tumor growth |
Tumor weight |
10.00 mg/kg |
DLD-1 (xenograft) |
Mus musculus |
BALB/c |
|
|
| Ponatinib |
Influence on tumor growth |
Tumor weight |
30.00 mg/kg |
DLD-1 (xenograft) |
Mus musculus |
BALB/c |
|
|
| Ponatinib |
Influence on protein activity in tumor tissue |
Immunohistochemistry |
10.00 mg/kg |
DLD-1 (xenograft) |
Mus musculus |
BALB/c |
p-STAT3 |
|
| Ponatinib |
Influence on protein activity in tumor tissue |
Immunohistochemistry |
30.00 mg/kg |
DLD-1 (xenograft) |
Mus musculus |
BALB/c |
p-STAT3 |
|
