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Experiments

Compound Investigated event Experiment type Concentration Cell line Organism Animal model Stat protein Details
FLL32 Influence on apoptosis Western Blot 4.00 µM primary human cells derived from recurrent cutaneous melanoma tumors Homo sapiens patient 1
FLL32 Influence on apoptosis Western Blot 4.00 µM primary human cells derived from recurrent cutaneous melanoma tumors Homo sapiens patient 2
FLL32 Influence on apoptosis Western Blot 4.00 µM primary human cells derived from recurrent cutaneous melanoma tumors Homo sapiens patient 1
FLL32 Influence on apoptosis Western Blot 4.00 µM primary human cells derived from recurrent cutaneous melanoma tumors Homo sapiens patient 2
FLL32 Influence on protein binding to DNA EMSA 4.00 µM STAT3
FLL32 Influence on caspase dependent apoptosis Western Blot 4.00 µM A375 Homo sapiens
FLL32 Influence on caspase dependent apoptosis Western Blot 4.00 µM A375 Homo sapiens
FLL32 Influence on caspase dependent apoptosis Western Blot 4.00 µM A375 Homo sapiens
FLL32 Influence on caspase dependent apoptosis Western Blot 4.00 µM A375 Homo sapiens
FLL32 Influence loss of mitochondrial membrane potential Flow cytometry 4.00 µM A375 Homo sapiens
FLL32 Influence on caspase dependent apoptosis in presence on caspase inhibitor Western Blot 4.00 µM A375 Homo sapiens
FLL32 Influence on caspase dependent apoptosis in presence on caspase inhibitor Western Blot 4.00 µM A375 Homo sapiens p-STAT3
FLL32 Influence on caspase dependent apoptosis in presence on caspase inhibitor Western Blot 4.00 µM A375 Homo sapiens STAT3
FLL32 Influence on caspase dependent apoptosis in presence on caspase inhibitor Western Blot 4.00 µM A375 Homo sapiens
FLL32 Influence on caspase dependent apoptosis in presence on caspase inhibitor Western Blot 4.00 µM A375 Homo sapiens
FLL32 Influence on protein activity in presence of IFNγ Western Blot 4.00 µM A375 Homo sapiens p-STAT3
FLL32 Influence on protein activity in presence of IFNγ Western Blot 4.00 µM A375 Homo sapiens STAT3
FLL32 Influence on protein activity in presence of IFNγ Western Blot 4.00 µM A375 Homo sapiens p-STAT1
FLL32 Influence on protein activity in presence of IFNγ Western Blot 4.00 µM A375 Homo sapiens STAT1
FLL32 Influence on protein activity in presence of IFNγ Western Blot 4.00 µM A375 Homo sapiens
FLL32 Influence on protein activity in presence of IL-6 Western Blot 4.00 µM PBMC Homo sapiens p-STAT3
FLL32 Influence on protein activity in presence of IL-6 Western Blot 4.00 µM PBMC Homo sapiens STAT3
FLL32 Influence on protein activity in presence of IL-6 Western Blot 4.00 µM PBMC Homo sapiens
FLL32 Influence on protein activity in presence of IFNγ Western Blot 4.00 µM PBMC Homo sapiens p-STAT3
FLL32 Influence on protein activity in presence of IFNγ Western Blot 4.00 µM PBMC Homo sapiens p-STAT1
FLL32 Influence on protein activity in presence of IFNγ Western Blot 4.00 µM PBMC Homo sapiens STAT1
FLL32 Influence on protein activity in presence of IFNγ Western Blot 4.00 µM PBMC Homo sapiens
FLL32 Influence on gene expression in presence of IFNγ RT-PCR 4.00 µM PBMC Homo sapiens
FLL32 Influence on protein activity in presence of IL-2 Western Blot 4.00 µM PBMC Homo sapiens p-STAT3
FLL32 Influence on protein activity in presence of IL-2 Western Blot 4.00 µM PBMC Homo sapiens STAT3
FLL32 Influence on protein activity in presence of IL-2 Western Blot 4.00 µM PBMC Homo sapiens p-STAT5
FLL32 Influence on protein activity in presence of IL-2 Western Blot 4.00 µM PBMC Homo sapiens STAT5
FLL32 Influence on protein activity in presence of IL-2 Western Blot 4.00 µM PBMC Homo sapiens
FLL32 Influence on cell viabiliy Flow cytometry 4.00 µM PBMC Homo sapiens
FLL32 Influence on cell viabiliy Western Blot 4.00 µM PBMC Homo sapiens