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Experiments

Compound Investigated event Experiment type Concentration Cell line Organism Animal model Stat protein Details
Brevilin A Influence on PI3K/AKT pathway members Western Blot 1.25 µM CNE-2 Homo sapiens p-STAT3
Brevilin A Influence on PI3K/AKT pathway members Western Blot 2.50 µM CNE-2 Homo sapiens p-STAT3
Brevilin A Influence on PI3K/AKT pathway members Western Blot 5.00 µM CNE-2 Homo sapiens p-STAT3
Brevilin A Influence on PI3K/AKT pathway members Western Blot 10.00 µM CNE-2 Homo sapiens p-STAT3
Brevilin A Influence on PI3K/AKT pathway members Western Blot 20.00 µM CNE-2 Homo sapiens p-STAT3
Brevilin A Influence on PI3K/AKT and STAT3 signaling pathways Western Blot 10.00 mg/kg CNE-2 (xenograft) Mus musculus BALB/c nude p-STAT3
Brevilin A Influence on PI3K/AKT and STAT3 signaling pathways Western Blot 20.00 mg/kg CNE-2 (xenograft) Mus musculus BALB/c nude p-STAT3
Brevilin A Influence on PI3K/AKT pathway members Western Blot 1.25 µM CNE-2 Homo sapiens STAT3
Brevilin A Influence on PI3K/AKT pathway members Western Blot 2.50 µM CNE-2 Homo sapiens STAT3
Brevilin A Influence on PI3K/AKT pathway members Western Blot 5.00 µM CNE-2 Homo sapiens STAT3
Brevilin A Influence on PI3K/AKT pathway members Western Blot 10.00 µM CNE-2 Homo sapiens STAT3
Brevilin A Influence on PI3K/AKT pathway members Western Blot 20.00 µM CNE-2 Homo sapiens STAT3
Brevilin A Influence on PI3K/AKT and STAT3 signaling pathways Western Blot 10.00 mg/kg CNE-2 (xenograft) Mus musculus BALB/c nude STAT3
Brevilin A Influence on PI3K/AKT and STAT3 signaling pathways Western Blot 20.00 mg/kg CNE-2 (xenograft) Mus musculus BALB/c nude STAT3
Brevilin A Influence on STAT3 signalling Western Blot 12.50 µM A549R Homo sapiens STAT3
Brevilin A Influence on STAT3 signalling Western Blot 25.00 µM A549R Homo sapiens STAT3
Brevilin A Influence on constitutive STAT3 activation Western Blot 5.00 µM DU145 Homo sapiens STAT3
Brevilin A Influence on constitutive STAT3 activation Western Blot 10.00 µM DU145 Homo sapiens STAT3
Brevilin A Influence on constitutive STAT3 activation Western Blot 15.00 µM DU145 Homo sapiens STAT3
Brevilin A Influence on constitutive STAT3 activation Western Blot 5.00 µM MDA-MB-468 Homo sapiens STAT3
Brevilin A Influence on constitutive STAT3 activation Western Blot 10.00 µM MDA-MB-468 Homo sapiens STAT3
Brevilin A Influence on constitutive STAT3 activation Western Blot 15.00 µM MDA-MB-468 Homo sapiens STAT3
Brevilin A Influence on protein upon cytokine treatment Western Blot 10.00 µM HEK293T Homo sapiens STAT3
Brevilin A Influence on protein upon cytokine treatment Western Blot 10.00 µM Hela Homo sapiens STAT3
Brevilin A Influence on protein upon cytokine treatment Western Blot 10.00 µM HepG2 Homo sapiens STAT3
Brevilin A Influence on JAK2-JH1 overexpressed protein Western Blot 10.00 µM HEK293T Homo sapiens STAT3
Brevilin A Influence on JAK2-JH1 overexpressed protein Western Blot 15.00 µM HEK293T Homo sapiens STAT3
Brevilin A Influence on protein overexpression Western Blot 15.00 µM HEK293T (JAK1-JH1) Homo sapiens STAT3
Brevilin A Influence on protein overexpression Western Blot 15.00 µM HEK293T (JAK2-JH1) Homo sapiens STAT3
Brevilin A Influence on protein overexpression Western Blot 15.00 µM HEK293T (JAK3-JH1) Homo sapiens STAT3
Brevilin A Influence on protein overexpression Western Blot 15.00 µM HEK293T (Tyk2-JH1) Homo sapiens STAT3
Brevilin A Influence on kinase activity (kinase assay) Tyk2-JH1 kinase domain Western Blot 10.00 µM HEK293T Homo sapiens STAT3
Brevilin A Influence on kinase activity (kinase assay) Tyk2-JH1 kinase domain Western Blot 20.00 µM HEK293T Homo sapiens STAT3
Brevilin A Influence on kinase activity (kinase assay) Tyk2-JH1 kinase domain Western Blot 40.00 µM HEK293T Homo sapiens STAT3
Brevilin A Influence on kinase activity (kinase assay) Tyk2-JH1 kinase domain Western Blot 80.00 µM HEK293T Homo sapiens STAT3
Brevilin A Measurement of IC50 value JAKs-JH1 truncated kinases Western Blot 5.00 µM HEK293T (JAK1-JH1) Homo sapiens STAT3
Brevilin A Measurement of IC50 value JAKs-JH1 truncated kinases Western Blot 7.50 µM HEK293T (JAK1-JH1) Homo sapiens STAT3
Brevilin A Measurement of IC50 value JAKs-JH1 truncated kinases Western Blot 10.00 µM HEK293T (JAK1-JH1) Homo sapiens STAT3
Brevilin A Measurement of IC50 value JAKs-JH1 truncated kinases Western Blot 12.50 µM HEK293T (JAK1-JH1) Homo sapiens STAT3
Brevilin A Measurement of IC50 value JAKs-JH1 truncated kinases Western Blot 15.00 µM HEK293T (JAK1-JH1) Homo sapiens STAT3
Brevilin A Measurement of IC50 value JAKs-JH1 truncated kinases Western Blot 17.50 µM HEK293T (JAK1-JH1) Homo sapiens STAT3
Brevilin A Measurement of IC50 value JAKs-JH1 truncated kinases Western Blot 20.00 µM HEK293T (JAK1-JH1) Homo sapiens STAT3
Brevilin A Measurement of IC50 value JAKs-JH1 truncated kinases Western Blot 5.00 µM HEK293T (JAK2-JH1) Homo sapiens STAT3
Brevilin A Measurement of IC50 value JAKs-JH1 truncated kinases Western Blot 7.50 µM HEK293T (JAK2-JH1) Homo sapiens STAT3
Brevilin A Measurement of IC50 value JAKs-JH1 truncated kinases Western Blot 10.00 µM HEK293T (JAK2-JH1) Homo sapiens STAT3
Brevilin A Measurement of IC50 value JAKs-JH1 truncated kinases Western Blot 12.50 µM HEK293T (JAK2-JH1) Homo sapiens STAT3
Brevilin A Measurement of IC50 value JAKs-JH1 truncated kinases Western Blot 15.00 µM HEK293T (JAK2-JH1) Homo sapiens STAT3
Brevilin A Measurement of IC50 value JAKs-JH1 truncated kinases Western Blot 17.50 µM HEK293T (JAK2-JH1) Homo sapiens STAT3
Brevilin A Measurement of IC50 value JAKs-JH1 truncated kinases Western Blot 20.00 µM HEK293T (JAK2-JH1) Homo sapiens STAT3
Brevilin A Measurement of IC50 value JAKs-JH1 truncated kinases Western Blot 5.00 µM HEK293T (JAK3-JH1) Homo sapiens STAT3