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Experiments

Compound Investigated event Experiment type Concentration Cell line Organism Animal model Stat protein Details
AZD1480 Influence on protein activity in presence of IL-6 Western Blot 0.50 µM MO4 Mus musculus p-STAT3
AZD1480 Influence on protein activity in presence of IL-6 Western Blot 1.00 µM MO4 Mus musculus p-STAT3
AZD1480 Influence on protein activity in presence of IL-6 Western Blot 5.00 µM MO4 Mus musculus p-STAT3
AZD1480 Influence on protein activity Western Blot 0.10 µM HD-LM2 Homo sapiens p-STAT3
AZD1480 Influence on protein activity Western Blot 0.50 µM HD-LM2 Homo sapiens p-STAT3
AZD1480 Influence on protein activity Western Blot 1.00 µM HD-LM2 Homo sapiens p-STAT3
AZD1480 Influence on protein activity Western Blot 5.00 µM HD-LM2 Homo sapiens p-STAT3
AZD1480 Influence on protein activity Western Blot 0.10 µM L-428 Homo sapiens p-STAT3
AZD1480 Influence on protein activity Western Blot 0.50 µM L-428 Homo sapiens p-STAT3
AZD1480 Influence on protein activity Western Blot 1.00 µM L-428 Homo sapiens p-STAT3
AZD1480 Influence on protein activity Western Blot 5.00 µM L-428 Homo sapiens p-STAT3
AZD1480 Influence on protein activity Western Blot 0.10 µM KM-H2 Homo sapiens p-STAT3
AZD1480 Influence on protein activity Western Blot 0.50 µM KM-H2 Homo sapiens p-STAT3
AZD1480 Influence on protein activity Western Blot 1.00 µM KM-H2 Homo sapiens p-STAT3
AZD1480 Influence on protein activity Western Blot 5.00 µM KM-H2 Homo sapiens p-STAT3
AZD1480 Influence on protein activity Western Blot 0.10 µM L-540 Homo sapiens p-STAT3
AZD1480 Influence on protein activity Western Blot 0.50 µM L-540 Homo sapiens p-STAT3
AZD1480 Influence on protein activity Western Blot 1.00 µM L-540 Homo sapiens p-STAT3
AZD1480 Influence on protein activity Western Blot 5.00 µM L-540 Homo sapiens p-STAT3
AZD1480 Influence on protein activity Western Blot 1.00 µM CLBL-1 Canis lupus familiaris p-STAT3
AZD1480 Influence on protein activity Western Blot 2.00 µM CLBL-1 Canis lupus familiaris p-STAT3
AZD1480 Influence on protein activity Western Blot 5.00 µM CLBL-1 Canis lupus familiaris p-STAT3
AZD1480 Influence on protein activity in presence of IL-6 Flow cytometry 5.00 µM CLBL-1 Canis lupus familiaris p-STAT3
AZD1480 Influence on protein activity Western Blot 0.30 µM NCI-H1650 Homo sapiens p-STAT3
AZD1480 Influence on protein activity Western Blot 0.30 µM HCC 827 Homo sapiens p-STAT3
AZD1480 Influence on protein activity Western Blot 0.30 µM AGS Homo sapiens p-STAT3
AZD1480 Influence on protein activity in presence of IL-6 Western Blot 0.30 µM Hep3B Homo sapiens p-STAT3
AZD1480 Influence on protein activity Western Blot 0.50 µM 786-O Mus musclus p-STAT3
AZD1480 Influence on protein activity Western Blot 1.00 µM 786-O Mus musclus p-STAT3
AZD1480 Influence on protein activity Western Blot 0.50 µM Renca Mus musclus p-STAT3
AZD1480 Influence on protein activity Western Blot 1.00 µM Renca Mus musclus p-STAT3
AZD1480 Influence on protein activity in tumor tissue Western Blot 50.00 mg/kg Renca (xenograft0 Mus musclus BALB/c p-STAT3
AZD1480 Influence on protein activity in metastatic tumor Western Blot 50.00 mg/kg Renca Mus musclus BALB/c p-STAT3
AZD1480 Influence on protein activity Western Blot 1.00 µM PAKHZT (xenograft) p-STAT3
AZD1480 Influence on protein activity Western Blot 1.00 µM PAKRSL (xenograft) p-STAT3
AZD1480 Influence on protein activity Western Blot 1.00 µM PALNTB (xenograft) p-STAT3
AZD1480 Influence on protein activity Western Blot 1.00 µM PAKYEP (xenograft) p-STAT3
AZD1480 Influence on protein activity Western Blot 1.00 µM PALJDL (xenograft) p-STAT3
AZD1480 Influence on protein activity in presence of selumetinib Western Blot 1.00 µM PALLSD (xenograft) p-STAT3
AZD1480 Influence on protein activity in presence of selumetinib Western Blot 1.00 µM PAMDRM (xenograft) p-STAT3
AZD1480 Influence on protein activity Western Blot 0.50 µM KCNR Homo sapiens p-STAT3 (Y705)
AZD1480 Influence on protein activity Western Blot 1.00 µM KCNR Homo sapiens p-STAT3 (Y705)
AZD1480 Influence on protein activity Western Blot 2.50 µM KCNR Homo sapiens p-STAT3 (Y705)
AZD1480 Influence on protein activity Western Blot 5.00 µM KCNR Homo sapiens p-STAT3 (Y705)
AZD1480 Influence on protein activity Western Blot 0.50 µM SY5Y Homo sapiens p-STAT3 (Y705)
AZD1480 Influence on protein activity Western Blot 1.00 µM SY5Y Homo sapiens p-STAT3 (Y705)
AZD1480 Influence on protein activity Western Blot 2.50 µM SY5Y Homo sapiens p-STAT3 (Y705)
AZD1480 Influence on protein activity Western Blot 5.00 µM SY5Y Homo sapiens p-STAT3 (Y705)
AZD1480 Influence on protein activity Western Blot 0.50 µM Rh18 Homo sapiens p-STAT3 (Y705)
AZD1480 Influence on protein activity Western Blot 1.00 µM Rh18 Homo sapiens p-STAT3 (Y705)