| AZD1480 |
Influence on protein activity |
Western Blot |
1.00 µM |
PCCl3-RET/PTC3 |
Rattus norvegicus |
|
p-STAT3 (Y705) |
|
| AZD1480 |
Influence on protein activity in presence of IL6 |
Western Blot |
0.50 µM |
U266 |
Homo sapiens |
|
p-STAT3 (Y705) |
|
| AZD1480 |
Influence on protein activity in presence of IL6 |
Western Blot |
1.00 µM |
U266 |
Homo sapiens |
|
p-STAT3 (Y705) |
|
| AZD1480 |
Influence on protein activity in presence of IL6 |
Western Blot |
2.00 µM |
U266 |
Homo sapiens |
|
p-STAT3 (Y705) |
|
| AZD1480 |
Influence on protein activity in presence of IL6 |
Western Blot |
0.50 µM |
Kms.11 |
Homo sapiens |
|
p-STAT3 (Y705) |
|
| AZD1480 |
Influence on protein activity in presence of IL6 |
Western Blot |
1.00 µM |
Kms.11 |
Homo sapiens |
|
p-STAT3 (Y705) |
|
| AZD1480 |
Influence on protein activity in presence of IL6 |
Western Blot |
2.00 µM |
Kms.11 |
Homo sapiens |
|
p-STAT3 (Y705) |
|
| AZD1480 |
Influence on protein activity in tumor tissue |
Western Blot |
30.00 mg/kg |
Kms.11 (xenograft) |
Mus musculus |
NOD/SCID IL2Rγ-null mice |
p-STAT3 (Y705) |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
1.00 µM |
U251-MG |
Homo sapiens |
|
p-STAT3 (Y705) |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
1.00 µM |
U87-MG |
Homo sapiens |
|
p-STAT3 (Y705) |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
1.00 µM |
4C8 |
Homo sapiens |
|
p-STAT3 (Y705) |
|
| AZD1480 |
Influence on protein activity in presence of OSM |
Western Blot |
0.10 µM |
U251-MG |
Homo sapiens |
|
p-STAT3 (Y705) |
|
| AZD1480 |
Influence on protein activity in presence of OSM |
Western Blot |
0.50 µM |
U251-MG |
Homo sapiens |
|
p-STAT3 (Y705) |
|
| AZD1480 |
Influence on protein activity in presence of OSM |
Western Blot |
1.00 µM |
U251-MG |
Homo sapiens |
|
p-STAT3 (Y705) |
|
| AZD1480 |
Influence on protein activity in presence of OSM |
Western Blot |
10.00 µM |
U251-MG |
Homo sapiens |
|
p-STAT3 (Y705) |
|
| AZD1480 |
Influence on protein activity in presence of OSM |
Western Blot |
0.10 µM |
U87-MG |
Homo sapiens |
|
p-STAT3 (Y705) |
|
| AZD1480 |
Influence on protein activity in presence of OSM |
Western Blot |
0.50 µM |
U87-MG |
Homo sapiens |
|
p-STAT3 (Y705) |
|
| AZD1480 |
Influence on protein activity in presence of OSM |
Western Blot |
1.00 µM |
U87-MG |
Homo sapiens |
|
p-STAT3 (Y705) |
|
| AZD1480 |
Influence on protein activity in presence of OSM |
Western Blot |
10.00 µM |
U87-MG |
Homo sapiens |
|
p-STAT3 (Y705) |
|
| AZD1480 |
Influence on protein activity in presence of OSM |
Western Blot |
0.10 µM |
4C8 |
Homo sapiens |
|
p-STAT3 (Y705) |
|
| AZD1480 |
Influence on protein activity in presence of OSM |
Western Blot |
0.50 µM |
4C8 |
Homo sapiens |
|
p-STAT3 (Y705) |
|
| AZD1480 |
Influence on protein activity in presence of OSM |
Western Blot |
1.00 µM |
4C8 |
Homo sapiens |
|
p-STAT3 (Y705) |
|
| AZD1480 |
Influence on protein activity in presence of OSM |
Western Blot |
10.00 µM |
4C8 |
Homo sapiens |
|
p-STAT3 (Y705) |
|
| AZD1480 |
Influence on protein activity in tumor tissue in presence of OSM |
Western Blot |
0.10 µM |
Xenograft X1066 |
Mus musculus |
athymic nude mice |
p-STAT3 (Y705) |
|
| AZD1480 |
Influence on protein activity in tumor tissue in presence of OSM |
Western Blot |
0.50 µM |
Xenograft X1066 |
Mus musculus |
athymic nude mice |
p-STAT3 (Y705) |
|
| AZD1480 |
Influence on protein activity in tumor tissue in presence of OSM |
Western Blot |
1.00 µM |
Xenograft X1066 |
Mus musculus |
athymic nude mice |
p-STAT3 (Y705) |
|
| AZD1480 |
Influence on protein activity in tumor tissue in presence of OSM |
Western Blot |
10.00 µM |
Xenograft X1066 |
Mus musculus |
athymic nude mice |
p-STAT3 (Y705) |
|
| AZD1480 |
Influence on CD133 expression in tumor tissue in presence of OSM |
Western Blot |
1.00 µM |
Xenograft X1066 |
Mus musculus |
athymic nude mice |
p-STAT3 (Y705) |
|
| AZD1480 |
Influence on protein-DNA interaction |
EMSA |
0.10 µM |
LN-17 |
Homo sapiens |
|
STAT3:STAT3 |
|
| AZD1480 |
Influence on protein-DNA interaction |
EMSA |
0.50 µM |
LN-17 |
Homo sapiens |
|
STAT3:STAT3 |
|
| AZD1480 |
Influence on protein-DNA interaction |
EMSA |
1.00 µM |
LN-17 |
Homo sapiens |
|
STAT3:STAT3 |
|
