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Experiments

Compound Investigated event Experiment type Concentration Cell line Organism Animal model Stat protein Details
AZD1480 Influence on protein activity in presence of IL-6 Western Blot 5.00 µM SY5Y Homo sapiens p-STAT3 (Y705)
AZD1480 Influence on protein activity in presence of IL-6 Western Blot 0.50 µM Rh18 Homo sapiens p-STAT3 (Y705)
AZD1480 Influence on protein activity in presence of IL-6 Western Blot 1.00 µM Rh18 Homo sapiens p-STAT3 (Y705)
AZD1480 Influence on protein activity in presence of IL-6 Western Blot 2.50 µM Rh18 Homo sapiens p-STAT3 (Y705)
AZD1480 Influence on protein activity in presence of IL-6 Western Blot 5.00 µM Rh18 Homo sapiens p-STAT3 (Y705)
AZD1480 Influence on protein activity in presence of IL-6 Western Blot 0.50 µM TC32 Homo sapiens p-STAT3 (Y705)
AZD1480 Influence on protein activity in presence of IL-6 Western Blot 1.00 µM TC32 Homo sapiens p-STAT3 (Y705)
AZD1480 Influence on protein activity in presence of IL-6 Western Blot 2.50 µM TC32 Homo sapiens p-STAT3 (Y705)
AZD1480 Influence on protein activity in presence of IL-6 Western Blot 5.00 µM TC32 Homo sapiens p-STAT3 (Y705)
AZD1480 Influence on protein activity in tumor tissue Western Blot 30.00 mg/kg KCNR (xenograft) Mus musculus athymic nude mice p-STAT3 (Y705)
AZD1480 Influence on protein activity in tumor tissue Western Blot 30.00 mg/kg SY5Y (xenograft) Mus musculus athymic nude mice p-STAT3 (Y705)
AZD1480 Influence on protein activity in tumor tissue Western Blot 30.00 mg/kg Rh18 (xenograft) Mus musculus athymic nude mice p-STAT3 (Y705)
AZD1480 Influence on protein activity in tumor tissue Western Blot 30.00 mg/kg TC32 (xenograft) Mus musculus athymic nude mice p-STAT3 (Y705)
AZD1480 Influence on late protein activity in tumor tissue Western Blot 30.00 mg/kg KCNR (xenograft) Mus musculus athymic nude mice p-STAT3 (Y705)
AZD1480 Influence on late protein activity in tumor tissue Western Blot 30.00 mg/kg SY5Y (xenograft) Mus musculus athymic nude mice p-STAT3 (Y705)
AZD1480 Influence on late protein activity in tumor tissue Western Blot 30.00 mg/kg Rh18 (xenograft) Mus musculus athymic nude mice p-STAT3 (Y705)
AZD1480 Influence on late protein activity in tumor tissue Western Blot 30.00 mg/kg TC32 (xenograft) Mus musculus athymic nude mice p-STAT3 (Y705)
AZD1480 Influence on protein activity in presence of OSM Western Blot 0.10 µM MEF-Stat3-YFP Mus musculus p-STAT3 (Y705)
AZD1480 Influence on protein activity in presence of OSM Western Blot 0.50 µM MEF-Stat3-YFP Mus musculus p-STAT3 (Y705)
AZD1480 Influence on protein activity in presence of OSM Western Blot 1.00 µM MEF-Stat3-YFP Mus musculus p-STAT3 (Y705)
AZD1480 Influence on protein activity Western Blot 0.05 µM LN-17 Homo sapiens p-STAT3 (Y705)
AZD1480 Influence on protein activity Western Blot 0.10 µM LN-17 Homo sapiens p-STAT3 (Y705)
AZD1480 Influence on protein activity Western Blot 0.25 µM LN-17 Homo sapiens p-STAT3 (Y705)
AZD1480 Influence on protein activity Western Blot 0.50 µM LN-17 Homo sapiens p-STAT3 (Y705)
AZD1480 Influence on protein activity Western Blot 1.00 µM LN-17 Homo sapiens p-STAT3 (Y705)
AZD1480 Influence on protein activity Western Blot 0.05 µM MDAH2774 Homo sapiens p-STAT3 (Y705)
AZD1480 Influence on protein activity Western Blot 0.10 µM MDAH2774 Homo sapiens p-STAT3 (Y705)
AZD1480 Influence on protein activity Western Blot 0.25 µM MDAH2774 Homo sapiens p-STAT3 (Y705)
AZD1480 Influence on protein activity Western Blot 0.50 µM MDAH2774 Homo sapiens p-STAT3 (Y705)
AZD1480 Influence on protein activity Western Blot 1.00 µM MDAH2774 Homo sapiens p-STAT3 (Y705)
AZD1480 Influence on protein activity Western Blot 0.10 µM MDA-MB-468 Homo sapiens p-STAT3 (Y705)
AZD1480 Influence on protein activity Western Blot 0.50 µM MDA-MB-468 Homo sapiens p-STAT3 (Y705)
AZD1480 Influence on protein activity Western Blot 1.00 µM MDA-MB-468 Homo sapiens p-STAT3 (Y705)
AZD1480 Influence on protein activity Western Blot 0.10 µM DU145 Homo sapiens p-STAT3 (Y705)
AZD1480 Influence on protein activity Western Blot 0.25 µM DU145 Homo sapiens p-STAT3 (Y705)
AZD1480 Influence on protein activity Western Blot 0.50 µM DU145 Homo sapiens p-STAT3 (Y705)
AZD1480 Influence on protein activity Western Blot 1.00 µM DU145 Homo sapiens p-STAT3 (Y705)
AZD1480 Influence on protein activity in presence of IL-6 Western Blot 3.00 µM MDAH2774 Homo sapiens p-STAT3 (Y705)
AZD1480 Influence on protein activity in presence of IL-6 Western Blot 0.10 µM MDA-MB-468 Homo sapiens p-STAT3 (Y705)
AZD1480 Influence on protein activity in presence of IL-6 Western Blot 0.50 µM MDA-MB-468 Homo sapiens p-STAT3 (Y705)
AZD1480 Influence on protein activity in presence of IL-6 Western Blot 1.00 µM MDA-MB-468 Homo sapiens p-STAT3 (Y705)
AZD1480 Influence on protein activity in presence of IL-6 Western Blot 0.10 µM DU145 Homo sapiens p-STAT3 (Y705)
AZD1480 Influence on protein activity in presence of IL-6 Western Blot 0.50 µM DU145 Homo sapiens p-STAT3 (Y705)
AZD1480 Influence on protein activity in presence of IL-6 Western Blot 1.00 µM DU145 Homo sapiens p-STAT3 (Y705)
AZD1480 Influence on protein activity in tumor tissue Western Blot 50.00 mg/kg DU145 (xenograft) Mus musculus p-STAT3 (Y705)
AZD1480 Influence on protein activity in tumor tissue Western Blot 50.00 mg/kg MDA-MB-468 (xenograft) Mus musculus p-STAT3 (Y705)
AZD1480 Influence on protein activity in tumor tissue Western Blot 50.00 mg/kg MDAH2774 (xenograft) Mus musculus p-STAT3 (Y705)
AZD1480 Influence on protein activity Western Blot 1.00 µM TPC-1 Homo sapiens p-STAT3 (Y705)
AZD1480 Influence on protein activity Western Blot 1.00 µM MZ-CRC1 Homo sapiens p-STAT3 (Y705)
AZD1480 Influence on protein activity Western Blot 1.00 µM TT Homo sapiens p-STAT3 (Y705)