| AZD1480 |
Influence on protein activity in tumor tissue in presence of OSM |
Western Blot |
0.50 µM |
Xenograft X1066 |
Mus musculus |
athymic nude mice |
STAT3 |
|
| AZD1480 |
Influence on protein activity in tumor tissue in presence of OSM |
Western Blot |
1.00 µM |
Xenograft X1066 |
Mus musculus |
athymic nude mice |
STAT3 |
|
| AZD1480 |
Influence on protein activity in tumor tissue in presence of OSM |
Western Blot |
10.00 µM |
Xenograft X1066 |
Mus musculus |
athymic nude mice |
STAT3 |
|
| AZD1480 |
Influence on CD133 expression in tumor tissue in presence of OSM |
Western Blot |
1.00 µM |
Xenograft X1066 |
Mus musculus |
athymic nude mice |
STAT3 |
|
| AZD1480 |
Inhibition of in vitro xenograft growth |
Western Blot |
30.00 mg/kg |
Xenograft X1046 |
Mus musculus |
athymic nude mice |
STAT3 |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
1.00 µM |
PAKHZT (xenograft) |
|
|
STAT3 |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
1.00 µM |
PAKRSL (xenograft) |
|
|
STAT3 |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
1.00 µM |
PALNTB (xenograft) |
|
|
STAT3 |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
1.00 µM |
PAKYEP (xenograft) |
|
|
STAT3 |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
1.00 µM |
PALJDL (xenograft) |
|
|
STAT3 |
|
| AZD1480 |
Influence on protein activity in presence of selumetinib |
Western Blot |
1.00 µM |
PALLSD (xenograft) |
|
|
STAT3 |
|
| AZD1480 |
Influence on protein activity in presence of selumetinib |
Western Blot |
1.00 µM |
PAMDRM (xenograft) |
|
|
STAT3 |
|
| AZD1480 |
Influence on protein activity |
Flow cytometry |
0.25 µM |
Th1 |
Mus musculus |
c57BL/6 |
STAT3 |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
0.50 µM |
BMDM |
Mus musculus |
c57BL/6 |
STAT3 |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
1.00 µM |
BMDM |
Mus musculus |
c57BL/6 |
STAT3 |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
2.00 µM |
BMDM |
Mus musculus |
c57BL/6 |
STAT3 |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
4.00 µM |
BMDM |
Mus musculus |
c57BL/6 |
STAT3 |
|
| AZD1480 |
Influence on protein activity in presence of IL-6 |
Western Blot |
0.50 µM |
BMDM |
Mus musculus |
c57BL/6 |
STAT3 |
|
| AZD1480 |
Influence on protein activity in presence of IL-6 |
Western Blot |
1.00 µM |
BMDM |
Mus musculus |
c57BL/6 |
STAT3 |
|
| AZD1480 |
Influence on protein activity in presence of IL-6 |
Western Blot |
2.00 µM |
BMDM |
Mus musculus |
c57BL/6 |
STAT3 |
|
| AZD1480 |
Influence on protein activity in presence of IL-6 |
Western Blot |
4.00 µM |
BMDM |
Mus musculus |
c57BL/6 |
STAT3 |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
25.00 mg/kg |
spinal cord |
Mus musculus |
c57BL/6 |
STAT3 |
|
| AZD1480 |
Influence on PLP-induced Relapsing-Remitting EAE Disease |
Western Blot |
25.00 mg/kg |
spinal cord |
Mus musculus |
c57BL/6 |
STAT3 |
|
| AZD1480 |
Influence on protein level in tumor tissue |
Western Blot |
20.00 mg/kg |
KT-10 |
Homo sapiens |
|
STAT3 |
|
| AZD1480 |
Influence on protein level in tumor tissue |
Western Blot |
10.00 mg/kg |
KT-10 |
Homo sapiens |
|
STAT3 |
|
| AZD1480 |
Influence on protein level in tumor tissue |
Western Blot |
20.00 mg/kg |
KT-13 |
Homo sapiens |
|
STAT3 |
|
| AZD1480 |
Influence on protein level in tumor tissue |
Western Blot |
10.00 mg/kg |
KT-13 |
Homo sapiens |
|
STAT3 |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
0.50 µM |
KCNR |
Homo sapiens |
|
p-STAT3 (Y705) |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
1.00 µM |
KCNR |
Homo sapiens |
|
p-STAT3 (Y705) |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
2.50 µM |
KCNR |
Homo sapiens |
|
p-STAT3 (Y705) |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
5.00 µM |
KCNR |
Homo sapiens |
|
p-STAT3 (Y705) |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
0.50 µM |
SY5Y |
Homo sapiens |
|
p-STAT3 (Y705) |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
1.00 µM |
SY5Y |
Homo sapiens |
|
p-STAT3 (Y705) |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
2.50 µM |
SY5Y |
Homo sapiens |
|
p-STAT3 (Y705) |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
5.00 µM |
SY5Y |
Homo sapiens |
|
p-STAT3 (Y705) |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
0.50 µM |
Rh18 |
Homo sapiens |
|
p-STAT3 (Y705) |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
1.00 µM |
Rh18 |
Homo sapiens |
|
p-STAT3 (Y705) |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
2.50 µM |
Rh18 |
Homo sapiens |
|
p-STAT3 (Y705) |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
5.00 µM |
Rh18 |
Homo sapiens |
|
p-STAT3 (Y705) |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
0.50 µM |
TC32 |
Homo sapiens |
|
p-STAT3 (Y705) |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
1.00 µM |
TC32 |
Homo sapiens |
|
p-STAT3 (Y705) |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
2.50 µM |
TC32 |
Homo sapiens |
|
p-STAT3 (Y705) |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
5.00 µM |
TC32 |
Homo sapiens |
|
p-STAT3 (Y705) |
|
| AZD1480 |
Influence on protein activity in presence of IL-6 |
Western Blot |
0.50 µM |
KCNR |
Homo sapiens |
|
p-STAT3 (Y705) |
|
| AZD1480 |
Influence on protein activity in presence of IL-6 |
Western Blot |
1.00 µM |
KCNR |
Homo sapiens |
|
p-STAT3 (Y705) |
|
| AZD1480 |
Influence on protein activity in presence of IL-6 |
Western Blot |
2.50 µM |
KCNR |
Homo sapiens |
|
p-STAT3 (Y705) |
|
| AZD1480 |
Influence on protein activity in presence of IL-6 |
Western Blot |
5.00 µM |
KCNR |
Homo sapiens |
|
p-STAT3 (Y705) |
|
| AZD1480 |
Influence on protein activity in presence of IL-6 |
Western Blot |
0.50 µM |
SY5Y |
Homo sapiens |
|
p-STAT3 (Y705) |
|
| AZD1480 |
Influence on protein activity in presence of IL-6 |
Western Blot |
1.00 µM |
SY5Y |
Homo sapiens |
|
p-STAT3 (Y705) |
|
| AZD1480 |
Influence on protein activity in presence of IL-6 |
Western Blot |
2.50 µM |
SY5Y |
Homo sapiens |
|
p-STAT3 (Y705) |
|
