| AZD1480 |
Influence on protein activity in presence of OSM |
Western Blot |
0.10 µM |
MEF-Stat3-YFP |
Mus musculus |
|
STAT3 |
|
| AZD1480 |
Influence on protein activity in presence of OSM |
Western Blot |
0.50 µM |
MEF-Stat3-YFP |
Mus musculus |
|
STAT3 |
|
| AZD1480 |
Influence on protein activity in presence of OSM |
Western Blot |
1.00 µM |
MEF-Stat3-YFP |
Mus musculus |
|
STAT3 |
|
| AZD1480 |
Influence on protein translocation in presence of OSM |
Immunofluorescence |
0.10 µM |
MEF-Stat3-YFP |
Mus musculus |
|
STAT3 |
|
| AZD1480 |
Influence on protein translocation in presence of OSM |
Immunofluorescence |
0.50 µM |
MEF-Stat3-YFP |
Mus musculus |
|
STAT3 |
|
| AZD1480 |
Influence on protein translocation in presence of OSM |
Immunofluorescence |
1.00 µM |
MEF-Stat3-YFP |
Mus musculus |
|
STAT3 |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
0.05 µM |
MDAH2774 |
Homo sapiens |
|
STAT3 |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
0.10 µM |
MDAH2774 |
Homo sapiens |
|
STAT3 |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
0.50 µM |
MDAH2774 |
Homo sapiens |
|
STAT3 |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
1.00 µM |
MDAH2774 |
Homo sapiens |
|
STAT3 |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
0.10 µM |
DU145 |
Homo sapiens |
|
STAT3 |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
0.25 µM |
DU145 |
Homo sapiens |
|
STAT3 |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
0.50 µM |
DU145 |
Homo sapiens |
|
STAT3 |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
1.00 µM |
DU145 |
Homo sapiens |
|
STAT3 |
|
| AZD1480 |
Influence on protein activity in presence of IL-6 |
Western Blot |
0.30 µM |
MDAH2774 |
Homo sapiens |
|
STAT3 |
|
| AZD1480 |
Influence on protein activity in tumor tissue |
Western Blot |
50.00 mg/kg |
MDA-MB-468 (xenograft) |
Mus musculus |
|
STAT3 |
|
| AZD1480 |
Influence on protein activity in tumor tissue |
Western Blot |
50.00 mg/kg |
MDAH2774 (xenograft) |
Mus musculus |
|
STAT3 |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
1.00 µM |
TPC-1 |
Homo sapiens |
|
STAT3 |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
1.00 µM |
MZ-CRC1 |
Homo sapiens |
|
STAT3 |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
1.00 µM |
TT |
Homo sapiens |
|
STAT3 |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
1.00 µM |
PCCl3-RET/PTC3 |
Rattus norvegicus |
|
STAT3 |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
0.50 µM |
786-O |
Mus musclus |
|
STAT3 |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
1.00 µM |
786-O |
Mus musclus |
|
STAT3 |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
0.50 µM |
Renca |
Mus musclus |
|
STAT3 |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
1.00 µM |
Renca |
Mus musclus |
|
STAT3 |
|
| AZD1480 |
Influence on protein activity in tumor tissue |
Western Blot |
50.00 mg/kg |
Renca (xenograft0 |
Mus musclus |
BALB/c |
STAT3 |
|
| AZD1480 |
Influence on protein activity in metastatic tumor |
Western Blot |
50.00 mg/kg |
Renca |
Mus musclus |
BALB/c |
STAT3 |
|
| AZD1480 |
Influence on protein activity in presence of IL6 |
Western Blot |
0.50 µM |
U266 |
Homo sapiens |
|
STAT3 |
|
| AZD1480 |
Influence on protein activity in presence of IL6 |
Western Blot |
1.00 µM |
U266 |
Homo sapiens |
|
STAT3 |
|
| AZD1480 |
Influence on protein activity in presence of IL6 |
Western Blot |
2.00 µM |
U266 |
Homo sapiens |
|
STAT3 |
|
| AZD1480 |
Influence on protein activity in presence of IL6 |
Western Blot |
0.50 µM |
Kms.11 |
Homo sapiens |
|
STAT3 |
|
| AZD1480 |
Influence on protein activity in presence of IL6 |
Western Blot |
1.00 µM |
Kms.11 |
Homo sapiens |
|
STAT3 |
|
| AZD1480 |
Influence on protein activity in presence of IL6 |
Western Blot |
2.00 µM |
Kms.11 |
Homo sapiens |
|
STAT3 |
|
| AZD1480 |
Influence on protein activity in tumor tissue |
Western Blot |
30.00 mg/kg |
Kms.11 (xenograft) |
Mus musculus |
NOD/SCID IL2Rγ-null mice |
STAT3 |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
1.00 µM |
U251-MG |
Homo sapiens |
|
STAT3 |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
1.00 µM |
U87-MG |
Homo sapiens |
|
STAT3 |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
1.00 µM |
4C8 |
Homo sapiens |
|
STAT3 |
|
| AZD1480 |
Influence on protein activity in presence of OSM |
Western Blot |
0.10 µM |
U251-MG |
Homo sapiens |
|
STAT3 |
|
| AZD1480 |
Influence on protein activity in presence of OSM |
Western Blot |
0.50 µM |
U251-MG |
Homo sapiens |
|
STAT3 |
|
| AZD1480 |
Influence on protein activity in presence of OSM |
Western Blot |
1.00 µM |
U251-MG |
Homo sapiens |
|
STAT3 |
|
| AZD1480 |
Influence on protein activity in presence of OSM |
Western Blot |
10.00 µM |
U251-MG |
Homo sapiens |
|
STAT3 |
|
| AZD1480 |
Influence on protein activity in presence of OSM |
Western Blot |
0.10 µM |
U87-MG |
Homo sapiens |
|
STAT3 |
|
| AZD1480 |
Influence on protein activity in presence of OSM |
Western Blot |
0.50 µM |
U87-MG |
Homo sapiens |
|
STAT3 |
|
| AZD1480 |
Influence on protein activity in presence of OSM |
Western Blot |
1.00 µM |
U87-MG |
Homo sapiens |
|
STAT3 |
|
| AZD1480 |
Influence on protein activity in presence of OSM |
Western Blot |
10.00 µM |
U87-MG |
Homo sapiens |
|
STAT3 |
|
| AZD1480 |
Influence on protein activity in presence of OSM |
Western Blot |
0.10 µM |
4C8 |
Homo sapiens |
|
STAT3 |
|
| AZD1480 |
Influence on protein activity in presence of OSM |
Western Blot |
0.50 µM |
4C8 |
Homo sapiens |
|
STAT3 |
|
| AZD1480 |
Influence on protein activity in presence of OSM |
Western Blot |
1.00 µM |
4C8 |
Homo sapiens |
|
STAT3 |
|
| AZD1480 |
Influence on protein activity in presence of OSM |
Western Blot |
10.00 µM |
4C8 |
Homo sapiens |
|
STAT3 |
|
| AZD1480 |
Influence on protein activity in tumor tissue in presence of OSM |
Western Blot |
0.10 µM |
Xenograft X1066 |
Mus musculus |
athymic nude mice |
STAT3 |
|
