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Experiments

Compound Investigated event Experiment type Concentration Cell line Organism Animal model Stat protein Details
AZD1480 Influence on downstream gene transcription RT-qPCR 1.00 µM U251-MG Homo sapiens
AZD1480 Influence on downstream gene transcription RT-qPCR 1.00 µM U87-MG Homo sapiens
AZD1480 Influence on downstream gene transcription RT-qPCR 1.00 µM 4C8 Homo sapiens
AZD1480 Influence on protein activity in tumor tissue in presence of OSM Western Blot 0.10 µM Xenograft X1066 Mus musculus athymic nude mice p-STAT3 (Y705)
AZD1480 Influence on protein activity in tumor tissue in presence of OSM Western Blot 0.50 µM Xenograft X1066 Mus musculus athymic nude mice p-STAT3 (Y705)
AZD1480 Influence on protein activity in tumor tissue in presence of OSM Western Blot 1.00 µM Xenograft X1066 Mus musculus athymic nude mice p-STAT3 (Y705)
AZD1480 Influence on protein activity in tumor tissue in presence of OSM Western Blot 10.00 µM Xenograft X1066 Mus musculus athymic nude mice p-STAT3 (Y705)
AZD1480 Influence on protein activity in tumor tissue in presence of OSM Western Blot 0.10 µM Xenograft X1066 Mus musculus athymic nude mice STAT3
AZD1480 Influence on protein activity in tumor tissue in presence of OSM Western Blot 0.50 µM Xenograft X1066 Mus musculus athymic nude mice STAT3
AZD1480 Influence on protein activity in tumor tissue in presence of OSM Western Blot 1.00 µM Xenograft X1066 Mus musculus athymic nude mice STAT3
AZD1480 Influence on protein activity in tumor tissue in presence of OSM Western Blot 10.00 µM Xenograft X1066 Mus musculus athymic nude mice STAT3
AZD1480 Influence on protein activity in tumor tissue in presence of OSM Western Blot 0.10 µM Xenograft X1066 Mus musculus athymic nude mice
AZD1480 Influence on protein activity in tumor tissue in presence of OSM Western Blot 0.50 µM Xenograft X1066 Mus musculus athymic nude mice
AZD1480 Influence on protein activity in tumor tissue in presence of OSM Western Blot 1.00 µM Xenograft X1066 Mus musculus athymic nude mice
AZD1480 Influence on protein activity in tumor tissue in presence of OSM Western Blot 10.00 µM Xenograft X1066 Mus musculus athymic nude mice
AZD1480 Influence on protein activity in tumor tissue in presence of OSM Western Blot 0.10 µM Xenograft X1066 Mus musculus athymic nude mice
AZD1480 Influence on protein activity in tumor tissue in presence of OSM Western Blot 0.50 µM Xenograft X1066 Mus musculus athymic nude mice
AZD1480 Influence on protein activity in tumor tissue in presence of OSM Western Blot 1.00 µM Xenograft X1066 Mus musculus athymic nude mice
AZD1480 Influence on protein activity in tumor tissue in presence of OSM Western Blot 10.00 µM Xenograft X1066 Mus musculus athymic nude mice
AZD1480 Influence on protein activity in tumor tissue in presence of OSM Western Blot 0.10 µM Xenograft X1066 Mus musculus athymic nude mice
AZD1480 Influence on protein activity in tumor tissue in presence of OSM Western Blot 0.50 µM Xenograft X1066 Mus musculus athymic nude mice
AZD1480 Influence on protein activity in tumor tissue in presence of OSM Western Blot 1.00 µM Xenograft X1066 Mus musculus athymic nude mice
AZD1480 Influence on protein activity in tumor tissue in presence of OSM Western Blot 10.00 µM Xenograft X1066 Mus musculus athymic nude mice
AZD1480 Influence on protein activity in tumor tissue in presence of OSM Western Blot 0.10 µM Xenograft X1066 Mus musculus athymic nude mice
AZD1480 Influence on protein activity in tumor tissue in presence of OSM Western Blot 0.50 µM Xenograft X1066 Mus musculus athymic nude mice
AZD1480 Influence on protein activity in tumor tissue in presence of OSM Western Blot 1.00 µM Xenograft X1066 Mus musculus athymic nude mice
AZD1480 Influence on protein activity in tumor tissue in presence of OSM Western Blot 10.00 µM Xenograft X1066 Mus musculus athymic nude mice
AZD1480 Influence on protein activity in tumor tissue in presence of OSM Western Blot 0.10 µM Xenograft X1066 Mus musculus athymic nude mice
AZD1480 Influence on protein activity in tumor tissue in presence of OSM Western Blot 0.50 µM Xenograft X1066 Mus musculus athymic nude mice
AZD1480 Influence on protein activity in tumor tissue in presence of OSM Western Blot 1.00 µM Xenograft X1066 Mus musculus athymic nude mice
AZD1480 Influence on protein activity in tumor tissue in presence of OSM Western Blot 10.00 µM Xenograft X1066 Mus musculus athymic nude mice
AZD1480 Inhibition of protein signalling in human glioblastoma xenograft tumors RT-qPCR 1.00 µM Xenograft X1016 Mus musculus athymic nude mice
AZD1480 Inhibition of protein signalling in human glioblastoma xenograft tumors RT-qPCR 1.00 µM Xenograft X1016 Mus musculus athymic nude mice
AZD1480 Inhibition of protein signalling in human glioblastoma xenograft tumors RT-qPCR 1.00 µM Xenograft X1016 Mus musculus athymic nude mice
AZD1480 Inhibition of cell proliferation in xenograft tumors WST-1 Cell Proliferation Assay 10.00 µM Xenograft X1016 Mus musculus athymic nude mice
AZD1480 Influence on CD133 expression in tumor tissue in presence of OSM Western Blot 1.00 µM Xenograft X1066 Mus musculus athymic nude mice p-STAT3 (Y705)
AZD1480 Influence on CD133 expression in tumor tissue in presence of OSM Western Blot 1.00 µM Xenograft X1066 Mus musculus athymic nude mice STAT3
AZD1480 Influence on CD133 expression in tumor tissue in presence of OSM Western Blot 1.00 µM Xenograft X1066 Mus musculus athymic nude mice
AZD1480 Influence on CD133 expression in tumor tissue in presence of OSM Western Blot 1.00 µM Xenograft X1066 Mus musculus athymic nude mice
AZD1480 Inhibition of in vitro xenograft growth Tumor volume 30.00 mg/kg Xenograft X1046 Mus musculus athymic nude mice
AZD1480 Inhibition of in vitro xenograft growth Tumor volume 30.00 mg/kg Xenograft X1066 Mus musculus athymic nude mice
AZD1480 Inhibition of in vitro xenograft growth Western Blot 30.00 mg/kg Xenograft X1046 Mus musculus athymic nude mice STAT3
AZD1480 Inhibition of in vitro xenograft growth Western Blot 30.00 mg/kg Xenograft X1046 Mus musculus athymic nude mice
AZD1480 Inhibition of in vitro xenograft growth Western Blot 30.00 mg/kg Xenograft X1046 Mus musculus athymic nude mice
AZD1480 Inhibition of in vitro xenograft growth Western Blot 30.00 mg/kg Xenograft X1046 Mus musculus athymic nude mice
AZD1480 Inhibition of in vitro xenograft growth Western Blot 30.00 mg/kg Xenograft X1046 Mus musculus athymic nude mice
AZD1480 Inhibition of in vitro xenograft growth Western Blot 30.00 mg/kg Xenograft X1046 Mus musculus athymic nude mice
AZD1480 Inhibition of in vitro xenograft growth Quantitative RT-PCR 30.00 mg/kg Xenograft X1046 Mus musculus athymic nude mice
AZD1480 Inhibition of in vitro xenograft growth Tumor weight 30.00 mg/kg Xenograft X1046 Mus musculus athymic nude mice
AZD1480 Influence on survival Survival Rate 50.00 mg/kg Xenograft X1016 Mus musculus athymic nude mice