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Experiments

Compound Investigated event Experiment type Concentration Cell line Organism Animal model Stat protein Details
AZD1480 Influence on STAT3 downstream target genes in presence of IL-6 Western Blot 0.25 µM U266 Homo sapiens
AZD1480 Influence on STAT3 downstream target genes in presence of IL-6 Western Blot 0.50 µM U266 Homo sapiens
AZD1480 Influence on STAT3 downstream target genes in presence of IL-6 Western Blot 1.00 µM U266 Homo sapiens
AZD1480 Influence on STAT3 downstream target genes in presence of IL-6 Western Blot 0.25 µM Kms.11 Homo sapiens
AZD1480 Influence on STAT3 downstream target genes in presence of IL-6 Western Blot 0.50 µM Kms.11 Homo sapiens
AZD1480 Influence on STAT3 downstream target genes in presence of IL-6 Western Blot 1.00 µM Kms.11 Homo sapiens
AZD1480 Influence on downstream gene transcription RT-qPCR 1.00 µM U251-MG Homo sapiens
AZD1480 Influence on downstream gene transcription RT-qPCR 1.00 µM U87-MG Homo sapiens
AZD1480 Influence on downstream gene transcription RT-qPCR 1.00 µM 4C8 Homo sapiens
AZD1480 Inhibition of protein signalling in human glioblastoma xenograft tumors RT-qPCR 1.00 µM Xenograft X1016 Mus musculus athymic nude mice