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Experiments

Compound Investigated event Experiment type Concentration Cell line Organism Animal model Stat protein Details
AZD1480 Influence on STAT3 downstream genes Real Time PCR 0.50 µM SY5Y Homo sapiens
AZD1480 Influence on STAT3 downstream genes Real Time PCR 0.50 µM Rh18 Homo sapiens
AZD1480 Influence on STAT3 downstream genes Real Time PCR 0.50 µM TC32 Homo sapiens
AZD1480 Influence on STAT3 downstream target genes in presence of IL-6 Western Blot 0.25 µM U266 Homo sapiens
AZD1480 Influence on STAT3 downstream target genes in presence of IL-6 Western Blot 0.50 µM U266 Homo sapiens
AZD1480 Influence on STAT3 downstream target genes in presence of IL-6 Western Blot 1.00 µM U266 Homo sapiens
AZD1480 Influence on STAT3 downstream target genes in presence of IL-6 Western Blot 0.25 µM Kms.11 Homo sapiens
AZD1480 Influence on STAT3 downstream target genes in presence of IL-6 Western Blot 0.50 µM Kms.11 Homo sapiens
AZD1480 Influence on STAT3 downstream target genes in presence of IL-6 Western Blot 1.00 µM Kms.11 Homo sapiens
AZD1480 Influence on downstream gene transcription RT-qPCR 1.00 µM U251-MG Homo sapiens
AZD1480 Influence on downstream gene transcription RT-qPCR 1.00 µM U87-MG Homo sapiens
AZD1480 Influence on downstream gene transcription RT-qPCR 1.00 µM 4C8 Homo sapiens
AZD1480 Inhibition of protein signalling in human glioblastoma xenograft tumors RT-qPCR 1.00 µM Xenograft X1016 Mus musculus athymic nude mice