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Experiments

Compound Investigated event Experiment type Concentration Cell line Organism Animal model Stat protein Details
AZD1480 Influence on protein activity Western Blot 0.10 µM MDAH2774 Homo sapiens
AZD1480 Influence on protein activity Western Blot 0.25 µM MDAH2774 Homo sapiens
AZD1480 Influence on protein activity Western Blot 0.50 µM MDAH2774 Homo sapiens
AZD1480 Influence on protein activity Western Blot 1.00 µM MDAH2774 Homo sapiens
AZD1480 Influence on protein activity Western Blot 0.10 µM MDA-MB-468 Homo sapiens
AZD1480 Influence on protein activity Western Blot 0.50 µM MDA-MB-468 Homo sapiens
AZD1480 Influence on protein activity Western Blot 1.00 µM MDA-MB-468 Homo sapiens
AZD1480 Influence on protein activity Western Blot 0.10 µM DU145 Homo sapiens
AZD1480 Influence on protein activity Western Blot 0.25 µM DU145 Homo sapiens
AZD1480 Influence on protein activity Western Blot 0.50 µM DU145 Homo sapiens
AZD1480 Influence on protein activity Western Blot 1.00 µM DU145 Homo sapiens
AZD1480 Influence on protein activity in presence of IL-6 Western Blot 0.10 µM MDA-MB-468 Homo sapiens
AZD1480 Influence on protein activity in presence of IL-6 Western Blot 0.50 µM MDA-MB-468 Homo sapiens
AZD1480 Influence on protein activity in presence of IL-6 Western Blot 1.00 µM MDA-MB-468 Homo sapiens
AZD1480 Influence on protein activity in presence of IL-6 Western Blot 0.10 µM DU145 Homo sapiens
AZD1480 Influence on protein activity in presence of IL-6 Western Blot 0.50 µM DU145 Homo sapiens
AZD1480 Influence on protein activity in presence of IL-6 Western Blot 1.00 µM DU145 Homo sapiens
AZD1480 Influence on protein activity in tumor tissue Western Blot 50.00 mg/kg DU145 (xenograft) Mus musculus
AZD1480 Influence on protein activity in tumor tissue Western Blot 50.00 mg/kg MDA-MB-468 (xenograft) Mus musculus
AZD1480 Influence on protein activity in tumor tissue Western Blot 50.00 mg/kg MDAH2774 (xenograft) Mus musculus
AZD1480 Influence on cell apoptosis Western Blot 1.00 µM TPC-1 Homo sapiens
AZD1480 Influence on cell apoptosis Western Blot 1.00 µM MZ-CRC1 Homo sapiens
AZD1480 Influence on cell apoptosis Western Blot 1.00 µM TT Homo sapiens
AZD1480 Influence on protein activity Western Blot 1.00 µM TPC-1 Homo sapiens
AZD1480 Influence on protein activity Western Blot 1.00 µM MZ-CRC1 Homo sapiens
AZD1480 Influence on protein activity Western Blot 1.00 µM TT Homo sapiens
AZD1480 Influence on protein activity in tumor tissue Western Blot 50.00 mg/kg Renca (xenograft0 Mus musclus BALB/c
AZD1480 Influence on angiogenesis Immunostaining 50.00 mg/kg Renca (xenograft0 Mus musclus BALB/c
AZD1480 Influence on protein activity in metastatic tumor Western Blot 50.00 mg/kg Renca Mus musclus BALB/c
AZD1480 Influence on STAT3 downstream target genes in presence of IL-6 Western Blot 0.25 µM U266 Homo sapiens
AZD1480 Influence on STAT3 downstream target genes in presence of IL-6 Western Blot 0.50 µM U266 Homo sapiens
AZD1480 Influence on STAT3 downstream target genes in presence of IL-6 Western Blot 1.00 µM U266 Homo sapiens
AZD1480 Influence on protein activity in tumor tissue Western Blot 30.00 mg/kg Kms.11 (xenograft) Mus musculus NOD/SCID IL2Rγ-null mice
AZD1480 Influence on protein activity Western Blot 1.00 µM PAKHZT (xenograft)
AZD1480 Influence on protein activity Western Blot 1.00 µM PAKRSL (xenograft)
AZD1480 Influence on protein activity Western Blot 1.00 µM PALNTB (xenograft)
AZD1480 Influence on protein activity Western Blot 1.00 µM PAKYEP (xenograft)
AZD1480 Influence on protein activity Western Blot 1.00 µM PALJDL (xenograft)
AZD1480 Influence on protein activity in presence of selumetinib Western Blot 1.00 µM PALLSD (xenograft)
AZD1480 Influence on protein activity in presence of selumetinib Western Blot 1.00 µM PAMDRM (xenograft)