| AZD1480 |
Inhibition of in vitro xenograft growth |
Western Blot |
30.00 mg/kg |
Xenograft X1046 |
Mus musculus |
athymic nude mice |
|
|
| AZD1480 |
Inhibition of in vitro xenograft growth |
Quantitative RT-PCR |
30.00 mg/kg |
Xenograft X1046 |
Mus musculus |
athymic nude mice |
|
|
| AZD1480 |
Inhibition of in vitro xenograft growth |
Tumor weight |
30.00 mg/kg |
Xenograft X1046 |
Mus musculus |
athymic nude mice |
|
|
| AZD1480 |
Influence on survival |
Survival Rate |
50.00 mg/kg |
Xenograft X1016 |
Mus musculus |
athymic nude mice |
|
|
| AZD1480 |
Influence on cell proliferation in tumor tissue |
Tumour volume |
10.00 mg/kg |
CWR22Rv1 |
Mus musculus |
|
|
|
| AZD1480 |
Influence on cell proliferation in tumor tissue |
Tumour volume |
30.00 mg/kg |
CWR22Rv1 |
Mus musculus |
|
|
|
| AZD1480 |
Influence on cell proliferation in tumor tissue |
Tumour volume |
10.00 mg/kg |
CWR22Pc |
Mus musculus |
|
|
|
| AZD1480 |
Influence on cell proliferation in tumor tissue |
Tumour volume |
30.00 mg/kg |
CWR22Pc |
Mus musculus |
|
|
|
| AZD1480 |
Influence on protein activity |
Western Blot |
30.00 mg/kg |
CWR22Rv1 |
Mus musculus |
|
STAT5A |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
30.00 mg/kg |
CWR22Rv1 |
Mus musculus |
|
STAT5B |
|
| AZD1480 |
Influence on protein activity |
Immunohistochemistry |
30.00 mg/kg |
CWR22Pc |
Mus musculus |
|
STAT5A |
|
| AZD1480 |
Influence on protein activity |
Immunohistochemistry |
30.00 mg/kg |
CWR22Pc |
Mus musculus |
|
STAT5B |
|
| AZD1480 |
Influence on protein activity |
Immunoprecipitation |
30.00 mg/kg |
CWR22Pc |
Mus musculus |
|
|
|
| AZD1480 |
Influence on protein activity |
Western Blot |
30.00 mg/kg |
CWR22Pc |
Mus musculus |
|
|
|
| AZD1480 |
Influence on cell proliferation |
Hematoxylin-eosin staining |
30.00 mg/kg |
CWR22Pc |
Mus musculus |
|
|
|
| AZD1480 |
Influence on protein activity |
Western Blot |
30.00 mg/kg |
CWR22Pc |
Mus musculus |
|
|
|
| AZD1480 |
Influence on protein activity |
Western Blot |
30.00 mg/kg |
CWR22Pc |
Mus musculus |
|
|
|
| AZD1480 |
Influence on protein activity |
Western Blot |
30.00 mg/kg |
CWR22Pc |
Mus musculus |
|
|
|
| AZD1480 |
Influence on cell differentiation |
Flow cytometry |
0.25 µM |
Th1 |
Mus musculus |
c57BL/6 |
STAT1 |
|
| AZD1480 |
Influence on cell differentiation |
Flow cytometry |
0.25 µM |
Th1 |
Mus musculus |
c57BL/6 |
STAT4 |
|
| AZD1480 |
Influence on cytokine secretion |
Flow cytometry |
0.25 µM |
Th1 |
Mus musculus |
c57BL/6 |
|
|
| AZD1480 |
Influence on cytokine secretion |
RT-qPCR |
0.25 µM |
Th1 |
Mus musculus |
c57BL/6 |
|
|
| AZD1480 |
Influence on protein activity |
Flow cytometry |
0.25 µM |
Th1 |
Mus musculus |
c57BL/6 |
STAT3 |
|
| AZD1480 |
|
Quantitative RT-PCR |
0.25 µM |
Th1 |
Mus musculus |
c57BL/6 |
|
|
| AZD1480 |
Influence on protein activity |
Western Blot |
0.50 µM |
BMDM |
Mus musculus |
c57BL/6 |
STAT1 |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
1.00 µM |
BMDM |
Mus musculus |
c57BL/6 |
STAT1 |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
2.00 µM |
BMDM |
Mus musculus |
c57BL/6 |
STAT1 |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
4.00 µM |
BMDM |
Mus musculus |
c57BL/6 |
STAT1 |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
0.50 µM |
BMDM |
Mus musculus |
c57BL/6 |
STAT3 |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
1.00 µM |
BMDM |
Mus musculus |
c57BL/6 |
STAT3 |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
2.00 µM |
BMDM |
Mus musculus |
c57BL/6 |
STAT3 |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
4.00 µM |
BMDM |
Mus musculus |
c57BL/6 |
STAT3 |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
0.25 µM |
BMDM |
Mus musculus |
c57BL/6 |
STAT5 |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
0.50 µM |
BMDM |
Mus musculus |
c57BL/6 |
STAT5 |
|
| AZD1480 |
Influence on protein activity in presence of IL-6 |
Western Blot |
0.50 µM |
BMDM |
Mus musculus |
c57BL/6 |
STAT3 |
|
| AZD1480 |
Influence on protein activity in presence of IL-6 |
Western Blot |
1.00 µM |
BMDM |
Mus musculus |
c57BL/6 |
STAT3 |
|
| AZD1480 |
Influence on protein activity in presence of IL-6 |
Western Blot |
2.00 µM |
BMDM |
Mus musculus |
c57BL/6 |
STAT3 |
|
| AZD1480 |
Influence on protein activity in presence of IL-6 |
Western Blot |
4.00 µM |
BMDM |
Mus musculus |
c57BL/6 |
STAT3 |
|
| AZD1480 |
Influence on protein activity in presence of IL-6 |
Western Blot |
0.50 µM |
BMDM |
Mus musculus |
c57BL/6 |
|
|
| AZD1480 |
Influence on protein activity in presence of IL-6 |
Western Blot |
1.00 µM |
BMDM |
Mus musculus |
c57BL/6 |
|
|
| AZD1480 |
Influence on protein activity in presence of IL-6 |
Western Blot |
2.00 µM |
BMDM |
Mus musculus |
c57BL/6 |
|
|
| AZD1480 |
Influence on protein activity in presence of IL-6 |
Western Blot |
4.00 µM |
BMDM |
Mus musculus |
c57BL/6 |
|
|
| AZD1480 |
Influence on protein activity in presence of IL-6 |
Western Blot |
0.50 µM |
BMDM |
Mus musculus |
c57BL/6 |
|
|
| AZD1480 |
Influence on protein activity in presence of IL-6 |
Western Blot |
1.00 µM |
BMDM |
Mus musculus |
c57BL/6 |
|
|
| AZD1480 |
Influence on protein activity in presence of IL-6 |
Western Blot |
2.00 µM |
BMDM |
Mus musculus |
c57BL/6 |
|
|
| AZD1480 |
Influence on protein activity in presence of IL-6 |
Western Blot |
4.00 µM |
BMDM |
Mus musculus |
c57BL/6 |
|
|
| AZD1480 |
Influence on protein activity in presence of IL-6 |
Western Blot |
0.50 µM |
BMDM |
Mus musculus |
c57BL/6 |
STAT1 |
|
| AZD1480 |
Influence on protein activity in presence of IL-6 |
Western Blot |
1.00 µM |
BMDM |
Mus musculus |
c57BL/6 |
STAT1 |
|
| AZD1480 |
Influence on protein activity in presence of IL-6 |
Western Blot |
2.00 µM |
BMDM |
Mus musculus |
c57BL/6 |
STAT1 |
|
| AZD1480 |
Influence on protein activity in presence of IL-6 |
Western Blot |
4.00 µM |
BMDM |
Mus musculus |
c57BL/6 |
STAT1 |
|
