| AZD1480 |
Influence on protein activity in tumor tissue |
Western Blot |
30.00 mg/kg |
Kms.11 (xenograft) |
Mus musculus |
NOD/SCID IL2Rγ-null mice |
|
|
| AZD1480 |
Influence on protein activity in tumor tissue |
Immunoprecipitation |
30.00 mg/kg |
Kms.11 (xenograft) |
Mus musculus |
NOD/SCID IL2Rγ-null mice |
|
|
| AZD1480 |
Influence on protein activity in tumor tissue |
Immunoprecipitation |
30.00 mg/kg |
Kms.11 (xenograft) |
Mus musculus |
NOD/SCID IL2Rγ-null mice |
|
|
| AZD1480 |
Influence on protein activity in tumor tissue |
Immunoprecipitation |
30.00 mg/kg |
Kms.11 (xenograft) |
Mus musculus |
NOD/SCID IL2Rγ-null mice |
|
|
| AZD1480 |
Influence on protein activity in tumor tissue |
Immunoprecipitation |
30.00 mg/kg |
Kms.11 (xenograft) |
Mus musculus |
NOD/SCID IL2Rγ-null mice |
|
|
| AZD1480 |
Influence on cell proliferation |
WST-1 Cell Proliferation Assay |
1.00 µM |
Murine Primary Astrocytes |
Mus musculus |
|
|
|
| AZD1480 |
Influence on cell proliferation |
WST-1 Cell Proliferation Assay |
10.00 µM |
Murine Primary Astrocytes |
Mus musculus |
|
|
|
| AZD1480 |
Influence on protein activity in tumor tissue in presence of OSM |
Western Blot |
0.10 µM |
Xenograft X1066 |
Mus musculus |
athymic nude mice |
p-STAT3 (Y705) |
|
| AZD1480 |
Influence on protein activity in tumor tissue in presence of OSM |
Western Blot |
0.50 µM |
Xenograft X1066 |
Mus musculus |
athymic nude mice |
p-STAT3 (Y705) |
|
| AZD1480 |
Influence on protein activity in tumor tissue in presence of OSM |
Western Blot |
1.00 µM |
Xenograft X1066 |
Mus musculus |
athymic nude mice |
p-STAT3 (Y705) |
|
| AZD1480 |
Influence on protein activity in tumor tissue in presence of OSM |
Western Blot |
10.00 µM |
Xenograft X1066 |
Mus musculus |
athymic nude mice |
p-STAT3 (Y705) |
|
| AZD1480 |
Influence on protein activity in tumor tissue in presence of OSM |
Western Blot |
0.10 µM |
Xenograft X1066 |
Mus musculus |
athymic nude mice |
STAT3 |
|
| AZD1480 |
Influence on protein activity in tumor tissue in presence of OSM |
Western Blot |
0.50 µM |
Xenograft X1066 |
Mus musculus |
athymic nude mice |
STAT3 |
|
| AZD1480 |
Influence on protein activity in tumor tissue in presence of OSM |
Western Blot |
1.00 µM |
Xenograft X1066 |
Mus musculus |
athymic nude mice |
STAT3 |
|
| AZD1480 |
Influence on protein activity in tumor tissue in presence of OSM |
Western Blot |
10.00 µM |
Xenograft X1066 |
Mus musculus |
athymic nude mice |
STAT3 |
|
| AZD1480 |
Influence on protein activity in tumor tissue in presence of OSM |
Western Blot |
0.10 µM |
Xenograft X1066 |
Mus musculus |
athymic nude mice |
|
|
| AZD1480 |
Influence on protein activity in tumor tissue in presence of OSM |
Western Blot |
0.50 µM |
Xenograft X1066 |
Mus musculus |
athymic nude mice |
|
|
| AZD1480 |
Influence on protein activity in tumor tissue in presence of OSM |
Western Blot |
1.00 µM |
Xenograft X1066 |
Mus musculus |
athymic nude mice |
|
|
| AZD1480 |
Influence on protein activity in tumor tissue in presence of OSM |
Western Blot |
10.00 µM |
Xenograft X1066 |
Mus musculus |
athymic nude mice |
|
|
| AZD1480 |
Influence on protein activity in tumor tissue in presence of OSM |
Western Blot |
0.10 µM |
Xenograft X1066 |
Mus musculus |
athymic nude mice |
|
|
| AZD1480 |
Influence on protein activity in tumor tissue in presence of OSM |
Western Blot |
0.50 µM |
Xenograft X1066 |
Mus musculus |
athymic nude mice |
|
|
| AZD1480 |
Influence on protein activity in tumor tissue in presence of OSM |
Western Blot |
1.00 µM |
Xenograft X1066 |
Mus musculus |
athymic nude mice |
|
|
| AZD1480 |
Influence on protein activity in tumor tissue in presence of OSM |
Western Blot |
10.00 µM |
Xenograft X1066 |
Mus musculus |
athymic nude mice |
|
|
| AZD1480 |
Influence on protein activity in tumor tissue in presence of OSM |
Western Blot |
0.10 µM |
Xenograft X1066 |
Mus musculus |
athymic nude mice |
|
|
| AZD1480 |
Influence on protein activity in tumor tissue in presence of OSM |
Western Blot |
0.50 µM |
Xenograft X1066 |
Mus musculus |
athymic nude mice |
|
|
| AZD1480 |
Influence on protein activity in tumor tissue in presence of OSM |
Western Blot |
1.00 µM |
Xenograft X1066 |
Mus musculus |
athymic nude mice |
|
|
| AZD1480 |
Influence on protein activity in tumor tissue in presence of OSM |
Western Blot |
10.00 µM |
Xenograft X1066 |
Mus musculus |
athymic nude mice |
|
|
| AZD1480 |
Influence on protein activity in tumor tissue in presence of OSM |
Western Blot |
0.10 µM |
Xenograft X1066 |
Mus musculus |
athymic nude mice |
|
|
| AZD1480 |
Influence on protein activity in tumor tissue in presence of OSM |
Western Blot |
0.50 µM |
Xenograft X1066 |
Mus musculus |
athymic nude mice |
|
|
| AZD1480 |
Influence on protein activity in tumor tissue in presence of OSM |
Western Blot |
1.00 µM |
Xenograft X1066 |
Mus musculus |
athymic nude mice |
|
|
| AZD1480 |
Influence on protein activity in tumor tissue in presence of OSM |
Western Blot |
10.00 µM |
Xenograft X1066 |
Mus musculus |
athymic nude mice |
|
|
| AZD1480 |
Influence on protein activity in tumor tissue in presence of OSM |
Western Blot |
0.10 µM |
Xenograft X1066 |
Mus musculus |
athymic nude mice |
|
|
| AZD1480 |
Influence on protein activity in tumor tissue in presence of OSM |
Western Blot |
0.50 µM |
Xenograft X1066 |
Mus musculus |
athymic nude mice |
|
|
| AZD1480 |
Influence on protein activity in tumor tissue in presence of OSM |
Western Blot |
1.00 µM |
Xenograft X1066 |
Mus musculus |
athymic nude mice |
|
|
| AZD1480 |
Influence on protein activity in tumor tissue in presence of OSM |
Western Blot |
10.00 µM |
Xenograft X1066 |
Mus musculus |
athymic nude mice |
|
|
| AZD1480 |
Inhibition of protein signalling in human glioblastoma xenograft tumors |
RT-qPCR |
1.00 µM |
Xenograft X1016 |
Mus musculus |
athymic nude mice |
|
|
| AZD1480 |
Inhibition of protein signalling in human glioblastoma xenograft tumors |
RT-qPCR |
1.00 µM |
Xenograft X1016 |
Mus musculus |
athymic nude mice |
|
|
| AZD1480 |
Inhibition of protein signalling in human glioblastoma xenograft tumors |
RT-qPCR |
1.00 µM |
Xenograft X1016 |
Mus musculus |
athymic nude mice |
|
|
| AZD1480 |
Inhibition of cell proliferation in xenograft tumors |
WST-1 Cell Proliferation Assay |
10.00 µM |
Xenograft X1016 |
Mus musculus |
athymic nude mice |
|
|
| AZD1480 |
Influence on CD133 expression in tumor tissue in presence of OSM |
Western Blot |
1.00 µM |
Xenograft X1066 |
Mus musculus |
athymic nude mice |
p-STAT3 (Y705) |
|
| AZD1480 |
Influence on CD133 expression in tumor tissue in presence of OSM |
Western Blot |
1.00 µM |
Xenograft X1066 |
Mus musculus |
athymic nude mice |
STAT3 |
|
| AZD1480 |
Influence on CD133 expression in tumor tissue in presence of OSM |
Western Blot |
1.00 µM |
Xenograft X1066 |
Mus musculus |
athymic nude mice |
|
|
| AZD1480 |
Influence on CD133 expression in tumor tissue in presence of OSM |
Western Blot |
1.00 µM |
Xenograft X1066 |
Mus musculus |
athymic nude mice |
|
|
| AZD1480 |
Inhibition of in vitro xenograft growth |
Tumor volume |
30.00 mg/kg |
Xenograft X1046 |
Mus musculus |
athymic nude mice |
|
|
| AZD1480 |
Inhibition of in vitro xenograft growth |
Tumor volume |
30.00 mg/kg |
Xenograft X1066 |
Mus musculus |
athymic nude mice |
|
|
| AZD1480 |
Inhibition of in vitro xenograft growth |
Western Blot |
30.00 mg/kg |
Xenograft X1046 |
Mus musculus |
athymic nude mice |
STAT3 |
|
| AZD1480 |
Inhibition of in vitro xenograft growth |
Western Blot |
30.00 mg/kg |
Xenograft X1046 |
Mus musculus |
athymic nude mice |
|
|
| AZD1480 |
Inhibition of in vitro xenograft growth |
Western Blot |
30.00 mg/kg |
Xenograft X1046 |
Mus musculus |
athymic nude mice |
|
|
| AZD1480 |
Inhibition of in vitro xenograft growth |
Western Blot |
30.00 mg/kg |
Xenograft X1046 |
Mus musculus |
athymic nude mice |
|
|
| AZD1480 |
Inhibition of in vitro xenograft growth |
Western Blot |
30.00 mg/kg |
Xenograft X1046 |
Mus musculus |
athymic nude mice |
|
|
