| AZD1480 |
Influence on late protein activity in tumor tissue |
Western Blot |
30.00 mg/kg |
Rh18 (xenograft) |
Mus musculus |
athymic nude mice |
|
|
| AZD1480 |
Influence on late protein activity in tumor tissue |
Western Blot |
30.00 mg/kg |
TC32 (xenograft) |
Mus musculus |
athymic nude mice |
|
|
| AZD1480 |
Influence on late protein activity in tumor tissue |
Western Blot |
30.00 mg/kg |
KCNR (xenograft) |
Mus musculus |
athymic nude mice |
|
|
| AZD1480 |
Influence on late protein activity in tumor tissue |
Western Blot |
30.00 mg/kg |
SY5Y (xenograft) |
Mus musculus |
athymic nude mice |
|
|
| AZD1480 |
Influence on late protein activity in tumor tissue |
Western Blot |
30.00 mg/kg |
Rh18 (xenograft) |
Mus musculus |
athymic nude mice |
|
|
| AZD1480 |
Influence on late protein activity in tumor tissue |
Western Blot |
30.00 mg/kg |
TC32 (xenograft) |
Mus musculus |
athymic nude mice |
|
|
| AZD1480 |
Influence on late protein activity in tumor tissue |
Western Blot |
30.00 mg/kg |
KCNR (xenograft) |
Mus musculus |
athymic nude mice |
|
|
| AZD1480 |
Influence on late protein activity in tumor tissue |
Western Blot |
30.00 mg/kg |
SY5Y (xenograft) |
Mus musculus |
athymic nude mice |
|
|
| AZD1480 |
Influence on late protein activity in tumor tissue |
Western Blot |
30.00 mg/kg |
Rh18 (xenograft) |
Mus musculus |
athymic nude mice |
|
|
| AZD1480 |
Influence on late protein activity in tumor tissue |
Western Blot |
30.00 mg/kg |
TC32 (xenograft) |
Mus musculus |
athymic nude mice |
|
|
| AZD1480 |
Influence on tumor growth |
Histological staining |
30.00 mg/kg |
KCNR (xenograft) |
Mus musculus |
athymic nude mice |
|
|
| AZD1480 |
Influence on tumor growth |
Histological staining |
30.00 mg/kg |
SY5Y (xenograft) |
Mus musculus |
athymic nude mice |
|
|
| AZD1480 |
Influence on tumor growth |
Histological staining |
30.00 mg/kg |
Rh18 (xenograft) |
Mus musculus |
athymic nude mice |
|
|
| AZD1480 |
Influence on tumor growth |
Histological staining |
30.00 mg/kg |
TC32 (xenograft) |
Mus musculus |
athymic nude mice |
|
|
| AZD1480 |
Influence on apoptosis |
Flow cytometry- annexin V staining |
0.50 µM |
MO4 |
Mus musculus |
|
|
|
| AZD1480 |
Influence on apoptosis |
Flow cytometry- annexin V staining |
0.50 µM |
K1735-C4 |
Mus musculus |
|
|
|
| AZD1480 |
Influence on apoptosis |
Flow cytometry- annexin V staining |
0.50 µM |
1087-mel |
Mus musculus |
|
|
|
| AZD1480 |
Influence on apoptosis |
Flow cytometry- annexin V staining |
1.00 µM |
MO4 |
Mus musculus |
|
|
|
| AZD1480 |
Influence on apoptosis |
Flow cytometry- annexin V staining |
1.00 µM |
K1735-C4 |
Mus musculus |
|
|
|
| AZD1480 |
Influence on apoptosis |
Flow cytometry- annexin V staining |
1.00 µM |
1087-mel |
Mus musculus |
|
|
|
| AZD1480 |
Influence on apoptosis |
Flow cytometry- annexin V staining |
5.00 µM |
MO4 |
Mus musculus |
|
|
|
| AZD1480 |
Influence on apoptosis |
Flow cytometry- annexin V staining |
5.00 µM |
K1735-C4 |
Mus musculus |
|
|
|
| AZD1480 |
Influence on apoptosis |
Flow cytometry- annexin V staining |
5.00 µM |
1087-mel |
Mus musculus |
|
|
|
| AZD1480 |
Influence on apoptosis |
Flow cytometry- annexin V staining |
10.00 µM |
MO4 |
Mus musculus |
|
|
|
| AZD1480 |
Influence on apoptosis |
Flow cytometry- annexin V staining |
10.00 µM |
K1735-C4 |
Mus musculus |
|
|
|
| AZD1480 |
Influence on apoptosis |
Flow cytometry- annexin V staining |
10.00 µM |
1087-mel |
Mus musculus |
|
|
|
| AZD1480 |
Influence on protein activity in presence of IL-6 |
Western Blot |
0.50 µM |
MO4 |
Mus musculus |
|
p-STAT3 |
|
| AZD1480 |
Influence on protein activity in presence of IL-6 |
Western Blot |
1.00 µM |
MO4 |
Mus musculus |
|
p-STAT3 |
|
| AZD1480 |
Influence on protein activity in presence of IL-6 |
Western Blot |
5.00 µM |
MO4 |
Mus musculus |
|
p-STAT3 |
|
| AZD1480 |
Influence on protein activity in presence of IL-6 |
Western Blot |
0.50 µM |
MO4 |
Mus musculus |
|
|
|
| AZD1480 |
Influence on protein activity in presence of IL-6 |
Western Blot |
1.00 µM |
MO4 |
Mus musculus |
|
|
|
| AZD1480 |
Influence on protein activity in presence of IL-6 |
Western Blot |
5.00 µM |
MO4 |
Mus musculus |
|
|
|
| AZD1480 |
|
Function of myeloid-derived suppressor cells |
30.00 mg/kg |
MO4 (xenograft) |
Mus musculus |
c57BL/6 |
|
|
| AZD1480 |
Influence on cell proliferation |
Flow cytometry |
1.75 µM |
Splenocytes |
Mus musculus |
|
|
|
| AZD1480 |
Influence on cell proliferation |
Flow cytometry |
1.50 µM |
Splenocytes |
Mus musculus |
|
|
|
| AZD1480 |
Influence on cell proliferation |
Flow cytometry |
1.25 µM |
Splenocytes |
Mus musculus |
|
|
|
| AZD1480 |
Influence on cell proliferation |
Flow cytometry |
1.00 µM |
Splenocytes |
Mus musculus |
|
|
|
| AZD1480 |
Influence on cell proliferation |
Flow cytometry |
0.75 µM |
Splenocytes |
Mus musculus |
|
|
|
| AZD1480 |
Influence on cell proliferation |
Flow cytometry |
0.50 µM |
Splenocytes |
Mus musculus |
|
|
|
| AZD1480 |
Influence on cell proliferation |
Flow cytometry |
0.25 µM |
Splenocytes |
Mus musculus |
|
|
|
| AZD1480 |
Influence on cell proliferation |
Flow cytometry |
0.10 µM |
Splenocytes |
Mus musculus |
|
|
|
| AZD1480 |
Influence on cell proliferation |
Flow cytometry |
0.05 µM |
Splenocytes |
Mus musculus |
|
|
|
| AZD1480 |
Influence on cell proliferation |
Flow cytometry |
0.03 µM |
Splenocytes |
Mus musculus |
|
|
|
| AZD1480 |
Influence on cell proliferation |
Flow cytometry |
0.01 µM |
Splenocytes |
Mus musculus |
|
|
|
| AZD1480 |
Influence on protein activity |
Western Blot |
0.00 µM |
Ba/F3 TEL-JAK2 |
Mus musculus |
|
p-STAT5 |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
0.01 µM |
Ba/F3 TEL-JAK2 |
Mus musculus |
|
p-STAT5 |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
0.03 µM |
Ba/F3 TEL-JAK2 |
Mus musculus |
|
p-STAT5 |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
0.10 µM |
Ba/F3 TEL-JAK2 |
Mus musculus |
|
p-STAT5 |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
0.30 µM |
Ba/F3 TEL-JAK2 |
Mus musculus |
|
p-STAT5 |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
1.00 µM |
Ba/F3 TEL-JAK2 |
Mus musculus |
|
p-STAT5 |
|
