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Experiments

Compound Investigated event Experiment type Concentration Cell line Organism Animal model Stat protein Details
AZD1480 Influence on protein activity in presence of IL-6 Western Blot 4.00 µM BMDM Mus musculus c57BL/6
AZD1480 Influence on protein activity in presence of IL-6 Western Blot 0.50 µM BMDM Mus musculus c57BL/6 STAT1
AZD1480 Influence on protein activity in presence of IL-6 Western Blot 1.00 µM BMDM Mus musculus c57BL/6 STAT1
AZD1480 Influence on protein activity in presence of IL-6 Western Blot 2.00 µM BMDM Mus musculus c57BL/6 STAT1
AZD1480 Influence on protein activity in presence of IL-6 Western Blot 4.00 µM BMDM Mus musculus c57BL/6 STAT1
AZD1480 Influence on protein activity Western Blot 25.00 mg/kg spinal cord Mus musculus c57BL/6 STAT4
AZD1480 Influence on protein activity Western Blot 25.00 mg/kg spinal cord Mus musculus c57BL/6 STAT3
AZD1480 Influence on PLP-induced Relapsing-Remitting EAE Disease Western Blot 25.00 mg/kg spinal cord Mus musculus c57BL/6 STAT1
AZD1480 Influence on PLP-induced Relapsing-Remitting EAE Disease Western Blot 25.00 mg/kg spinal cord Mus musculus c57BL/6 STAT3
AZD1480 Influence on protein level in tumor tissue Western Blot 20.00 mg/kg KT-10 Homo sapiens STAT3
AZD1480 Influence on protein level in tumor tissue Western Blot 20.00 mg/kg KT-10 Homo sapiens
AZD1480 Influence on protein level in tumor tissue Western Blot 10.00 mg/kg KT-10 Homo sapiens STAT3
AZD1480 Influence on protein level in tumor tissue Western Blot 10.00 mg/kg KT-10 Homo sapiens
AZD1480 Influence on protein level in tumor tissue Western Blot 20.00 mg/kg KT-13 Homo sapiens STAT3
AZD1480 Influence on protein level in tumor tissue Western Blot 20.00 mg/kg KT-13 Homo sapiens
AZD1480 Influence on protein level in tumor tissue Western Blot 10.00 mg/kg KT-13 Homo sapiens STAT3
AZD1480 Influence on protein level in tumor tissue Western Blot 10.00 mg/kg KT-13 Homo sapiens
AZD1480 Influence on kinase activity Cell-free kinase assay; Western Blot 0.10 µM Homo sapiens p-STAT1
AZD1480 Influence on kinase activity Cell-free kinase assay; Western Blot 0.20 µM Homo sapiens p-STAT1
AZD1480 Influence on kinase activity Cell-free kinase assay; Western Blot 0.50 µM Homo sapiens p-STAT1
AZD1480 Influence on kinase activity Cell-free kinase assay; Western Blot 1.00 µM Homo sapiens p-STAT1
AZD1480 Influence on kinase activity Cell-free kinase assay; Western Blot 5.00 µM Homo sapiens p-STAT1
AZD1480 Influence on kinase activity Cell-free kinase assay; Western Blot 10.00 µM Homo sapiens p-STAT1
AZD1480 Influence on kinase activity Cell-free kinase assay; Western Blot 0.10 µM Homo sapiens STAT1
AZD1480 Influence on kinase activity Cell-free kinase assay; Western Blot 0.20 µM Homo sapiens STAT1
AZD1480 Influence on kinase activity Cell-free kinase assay; Western Blot 0.50 µM Homo sapiens STAT1
AZD1480 Influence on kinase activity Cell-free kinase assay; Western Blot 1.00 µM Homo sapiens STAT1
AZD1480 Influence on kinase activity Cell-free kinase assay; Western Blot 5.00 µM Homo sapiens STAT1
AZD1480 Influence on kinase activity Cell-free kinase assay; Western Blot 10.00 µM Homo sapiens STAT1
AZD1480 Influence on kinase activity Cell-free kinase assay; Western Blot 0.20 µM Homo sapiens
AZD1480 Influence on kinase activity Cell-free kinase assay; Western Blot 0.50 µM Homo sapiens
AZD1480 Influence on kinase activity Cell-free kinase assay; Western Blot 1.00 µM Homo sapiens
AZD1480 Influence on kinase activity Cell-free kinase assay; Western Blot 5.00 µM Homo sapiens
AZD1480 Influence on kinase activity Cell-free kinase assay; Western Blot 10.00 µM Homo sapiens
AZD1480 Influence on kinase activity Cell-free kinase assay; Western Blot 0.20 µM Homo sapiens
AZD1480 Influence on kinase activity Cell-free kinase assay; Western Blot 0.50 µM Homo sapiens
AZD1480 Influence on kinase activity Cell-free kinase assay; Western Blot 1.00 µM Homo sapiens
AZD1480 Influence on kinase activity Cell-free kinase assay; Western Blot 5.00 µM Homo sapiens
AZD1480 Influence on kinase activity Cell-free kinase assay; Western Blot 10.00 µM Homo sapiens