| AZD1480 |
Influence on cell proliferation in tumor tissue |
Tumor volume |
50.00 mg/kg |
MEF-Stat3-YFP |
Mus musculus |
|
|
|
| AZD1480 |
Influence on cell proliferation in tumor tissue |
Tumor volume |
50.00 mg/kg |
DU145 (xenograft) |
Mus musculus |
|
|
|
| AZD1480 |
Influence on cell proliferation in tumor tissue |
Tumor volume |
50.00 mg/kg |
MDA-MB-468 (xenograft) |
Mus musculus |
|
|
|
| AZD1480 |
Influence on cell proliferation in tumor tissue |
Tumor volume |
50.00 mg/kg |
MDAH2774 (xenograft) |
Mus musculus |
|
|
|
| AZD1480 |
Influence on protein activity in tumor tissue |
Western Blot |
50.00 mg/kg |
DU145 (xenograft) |
Mus musculus |
|
p-STAT3 (Y705) |
|
| AZD1480 |
Influence on protein activity in tumor tissue |
Western Blot |
50.00 mg/kg |
DU145 (xenograft) |
Mus musculus |
|
|
|
| AZD1480 |
Influence on protein activity in tumor tissue |
Western Blot |
50.00 mg/kg |
MDA-MB-468 (xenograft) |
Mus musculus |
|
p-STAT3 (Y705) |
|
| AZD1480 |
Influence on protein activity in tumor tissue |
Western Blot |
50.00 mg/kg |
MDA-MB-468 (xenograft) |
Mus musculus |
|
STAT3 |
|
| AZD1480 |
Influence on protein activity in tumor tissue |
Western Blot |
50.00 mg/kg |
MDA-MB-468 (xenograft) |
Mus musculus |
|
|
|
| AZD1480 |
Influence on protein activity in tumor tissue |
Western Blot |
50.00 mg/kg |
MDAH2774 (xenograft) |
Mus musculus |
|
p-STAT3 (Y705) |
|
| AZD1480 |
Influence on protein activity in tumor tissue |
Western Blot |
50.00 mg/kg |
MDAH2774 (xenograft) |
Mus musculus |
|
STAT3 |
|
| AZD1480 |
Influence on protein activity in tumor tissue |
Western Blot |
50.00 mg/kg |
MDAH2774 (xenograft) |
Mus musculus |
|
|
|
| AZD1480 |
Influence on protein activity in tumor tissue |
Western Blot |
50.00 mg/kg |
MDAH2774 (xenograft) |
Mus musculus |
|
|
|
| AZD1480 |
Influence on protein activity in tumor tissue |
Western Blot |
50.00 mg/kg |
MDAH2774 (xenograft) |
Mus musculus |
|
|
|
| AZD1480 |
Influence on protein activity in tumor tissue |
Western Blot |
50.00 mg/kg |
MDAH2774 (xenograft) |
Mus musculus |
|
|
|
| AZD1480 |
Influence on protein activity in tumor tissue |
Western Blot |
50.00 mg/kg |
MDAH2774 (xenograft) |
Mus musculus |
|
|
|
| AZD1480 |
Influence on cell proliferation in tumor tissue |
Tumor volume |
50.00 mg/kg |
Renca (xenograft0 |
Mus musclus |
BALB/c |
|
|
| AZD1480 |
Influence on protein activity in tumor tissue |
Western Blot |
50.00 mg/kg |
Renca (xenograft0 |
Mus musclus |
BALB/c |
p-STAT3 |
|
| AZD1480 |
Influence on protein activity in tumor tissue |
Western Blot |
50.00 mg/kg |
Renca (xenograft0 |
Mus musclus |
BALB/c |
STAT3 |
|
| AZD1480 |
Influence on protein activity in tumor tissue |
Western Blot |
50.00 mg/kg |
Renca (xenograft0 |
Mus musclus |
BALB/c |
|
|
| AZD1480 |
Influence on protein activity in tumor tissue |
Western Blot |
50.00 mg/kg |
Renca (xenograft0 |
Mus musclus |
BALB/c |
|
|
| AZD1480 |
Influence on protein activity in tumor tissue |
Western Blot |
50.00 mg/kg |
Renca (xenograft0 |
Mus musclus |
BALB/c |
|
|
| AZD1480 |
Influence on angiogenesis |
Immunostaining |
50.00 mg/kg |
Renca (xenograft0 |
Mus musclus |
BALB/c |
|
|
| AZD1480 |
Influence on angiogenesis |
Immunostaining |
50.00 mg/kg |
Renca (xenograft0 |
Mus musclus |
BALB/c |
|
|
| AZD1480 |
Influence on angiogenesis |
Immunostaining |
50.00 mg/kg |
Renca (xenograft0 |
Mus musclus |
BALB/c |
|
|
| AZD1480 |
Influence on angiogenesis |
Immunostaining |
50.00 mg/kg |
Renca (xenograft0 |
Mus musclus |
BALB/c |
|
|
| AZD1480 |
Influence on tumor metastasis |
Number of nodules |
50.00 mg/kg |
Renca |
Mus musclus |
BALB/c |
|
|
| AZD1480 |
Influence on protein activity in metastatic tumor |
Western Blot |
50.00 mg/kg |
Renca |
Mus musclus |
BALB/c |
p-STAT3 |
|
| AZD1480 |
Influence on protein activity in metastatic tumor |
Western Blot |
50.00 mg/kg |
Renca |
Mus musclus |
BALB/c |
STAT3 |
|
| AZD1480 |
Influence on protein activity in metastatic tumor |
Western Blot |
50.00 mg/kg |
Renca |
Mus musclus |
BALB/c |
|
|
| AZD1480 |
Influence on protein activity in metastatic tumor |
Western Blot |
50.00 mg/kg |
Renca |
Mus musclus |
BALB/c |
|
|
| AZD1480 |
Influence on protein activity in metastatic tumor |
Western Blot |
50.00 mg/kg |
Renca |
Mus musclus |
BALB/c |
|
|
| AZD1480 |
Influence on survival |
Survival Rate |
50.00 mg/kg |
Xenograft X1016 |
Mus musculus |
athymic nude mice |
|
|
| AZD1480 |
Influence on protein-protein interaction |
Immunoprecipitation |
50.00 nM |
PC-3 |
Homo sapiens |
|
STAT5 |
|
| AZD1480 |
Influence on protein translocation |
Immunostaining |
50.00 nM |
PC-3 |
Homo sapiens |
|
STAT5A |
|
| AZD1480 |
Influence on protein translocation |
Immunostaining |
50.00 nM |
PC-3 |
Homo sapiens |
|
STAT5B |
|
| AZD1480 |
Influence on protein-DNA interaction |
EMSA |
50.00 nM |
PC-3 |
Homo sapiens |
|
STAT5A |
|
| AZD1480 |
Influence on protein-DNA interaction |
EMSA |
50.00 nM |
PC-3 |
Homo sapiens |
|
STAT5B |
|
| AZD1480 |
Influence on cell proliferation |
Flow cytometry |
50.00 mg/kg |
CD4+T |
Mus musculus |
c57BL/6 |
|
|
| AZD1480 |
Influence on hematologic parameters |
HEMAVET |
50.00 mg/kg |
RBC |
Mus musculus |
c57BL/6 |
|
|
| AZD1480 |
Influence on hematologic parameters |
HEMAVET |
50.00 mg/kg |
WBC |
Mus musculus |
c57BL/6 |
|
|
| AZD1480 |
Influence on hematologic parameters |
HEMAVET |
50.00 mg/kg |
NEU |
Mus musculus |
c57BL/6 |
|
|
| AZD1480 |
Influence on hematologic parameters |
HEMAVET |
50.00 mg/kg |
LYM |
Mus musculus |
c57BL/6 |
|
|
| AZD1480 |
Influence on hematologic parameters |
HEMAVET |
50.00 mg/kg |
MONO |
Mus musculus |
c57BL/6 |
|
|
