| AZD1480 |
Influence on late protein activity in tumor tissue |
Western Blot |
30.00 mg/kg |
Rh18 (xenograft) |
Mus musculus |
athymic nude mice |
|
|
| AZD1480 |
Influence on late protein activity in tumor tissue |
Western Blot |
30.00 mg/kg |
TC32 (xenograft) |
Mus musculus |
athymic nude mice |
|
|
| AZD1480 |
Influence on late protein activity in tumor tissue |
Western Blot |
30.00 mg/kg |
KCNR (xenograft) |
Mus musculus |
athymic nude mice |
|
|
| AZD1480 |
Influence on late protein activity in tumor tissue |
Western Blot |
30.00 mg/kg |
SY5Y (xenograft) |
Mus musculus |
athymic nude mice |
|
|
| AZD1480 |
Influence on late protein activity in tumor tissue |
Western Blot |
30.00 mg/kg |
Rh18 (xenograft) |
Mus musculus |
athymic nude mice |
|
|
| AZD1480 |
Influence on late protein activity in tumor tissue |
Western Blot |
30.00 mg/kg |
TC32 (xenograft) |
Mus musculus |
athymic nude mice |
|
|
| AZD1480 |
Influence on late protein activity in tumor tissue |
Western Blot |
30.00 mg/kg |
KCNR (xenograft) |
Mus musculus |
athymic nude mice |
|
|
| AZD1480 |
Influence on late protein activity in tumor tissue |
Western Blot |
30.00 mg/kg |
SY5Y (xenograft) |
Mus musculus |
athymic nude mice |
|
|
| AZD1480 |
Influence on late protein activity in tumor tissue |
Western Blot |
30.00 mg/kg |
Rh18 (xenograft) |
Mus musculus |
athymic nude mice |
|
|
| AZD1480 |
Influence on late protein activity in tumor tissue |
Western Blot |
30.00 mg/kg |
TC32 (xenograft) |
Mus musculus |
athymic nude mice |
|
|
| AZD1480 |
Influence on tumor growth |
Histological staining |
30.00 mg/kg |
KCNR (xenograft) |
Mus musculus |
athymic nude mice |
|
|
| AZD1480 |
Influence on tumor growth |
Histological staining |
30.00 mg/kg |
SY5Y (xenograft) |
Mus musculus |
athymic nude mice |
|
|
| AZD1480 |
Influence on tumor growth |
Histological staining |
30.00 mg/kg |
Rh18 (xenograft) |
Mus musculus |
athymic nude mice |
|
|
| AZD1480 |
Influence on tumor growth |
Histological staining |
30.00 mg/kg |
TC32 (xenograft) |
Mus musculus |
athymic nude mice |
|
|
| AZD1480 |
|
Function of myeloid-derived suppressor cells |
30.00 mg/kg |
MO4 (xenograft) |
Mus musculus |
c57BL/6 |
|
|
| AZD1480 |
Influence on cell proliferation in tumor tissue |
Tumor volume |
30.00 mg/kg |
TPC-1 (xenograft) |
Mus musclus |
|
|
|
| AZD1480 |
Influence on cell proliferation in tumor tissue |
Immunostaining |
30.00 mg/kg |
TPC-1 (xenograft) |
Mus musclus |
nu/nu Nude mice |
|
|
| AZD1480 |
Influence on cell proliferation in tumor tissue |
Immunostaining |
30.00 mg/kg |
TPC-1 (xenograft) |
Mus musclus |
nu/nu Nude mice |
|
|
| AZD1480 |
Influence on cell proliferation in tumor tissue |
Immunostaining |
30.00 mg/kg |
TPC-1 (xenograft) |
Mus musclus |
nu/nu Nude mice |
|
|
| AZD1480 |
Influence on cell proliferation in tumor tissue |
Tumor volume |
30.00 mg/kg |
Kms.11 (xenograft) |
Mus musculus |
NOD/SCID IL2Rγ-null mice |
|
|
| AZD1480 |
Influence on protein activity in tumor tissue |
Western Blot |
30.00 mg/kg |
Kms.11 (xenograft) |
Mus musculus |
NOD/SCID IL2Rγ-null mice |
p-STAT3 (Y705) |
|
| AZD1480 |
Influence on protein activity in tumor tissue |
Western Blot |
30.00 mg/kg |
Kms.11 (xenograft) |
Mus musculus |
NOD/SCID IL2Rγ-null mice |
STAT3 |
|
| AZD1480 |
Influence on protein activity in tumor tissue |
Western Blot |
30.00 mg/kg |
Kms.11 (xenograft) |
Mus musculus |
NOD/SCID IL2Rγ-null mice |
|
|
| AZD1480 |
Influence on protein activity in tumor tissue |
Western Blot |
30.00 mg/kg |
Kms.11 (xenograft) |
Mus musculus |
NOD/SCID IL2Rγ-null mice |
|
|
| AZD1480 |
Influence on protein activity in tumor tissue |
Western Blot |
30.00 mg/kg |
Kms.11 (xenograft) |
Mus musculus |
NOD/SCID IL2Rγ-null mice |
|
|
| AZD1480 |
Influence on protein activity in tumor tissue |
Western Blot |
30.00 mg/kg |
Kms.11 (xenograft) |
Mus musculus |
NOD/SCID IL2Rγ-null mice |
|
|
| AZD1480 |
Influence on protein activity in tumor tissue |
Immunoprecipitation |
30.00 mg/kg |
Kms.11 (xenograft) |
Mus musculus |
NOD/SCID IL2Rγ-null mice |
|
|
| AZD1480 |
Influence on protein activity in tumor tissue |
Immunoprecipitation |
30.00 mg/kg |
Kms.11 (xenograft) |
Mus musculus |
NOD/SCID IL2Rγ-null mice |
|
|
| AZD1480 |
Influence on protein activity in tumor tissue |
Immunoprecipitation |
30.00 mg/kg |
Kms.11 (xenograft) |
Mus musculus |
NOD/SCID IL2Rγ-null mice |
|
|
| AZD1480 |
Influence on protein activity in tumor tissue |
Immunoprecipitation |
30.00 mg/kg |
Kms.11 (xenograft) |
Mus musculus |
NOD/SCID IL2Rγ-null mice |
|
|
| AZD1480 |
Inhibition of in vitro xenograft growth |
Tumor volume |
30.00 mg/kg |
Xenograft X1046 |
Mus musculus |
athymic nude mice |
|
|
| AZD1480 |
Inhibition of in vitro xenograft growth |
Tumor volume |
30.00 mg/kg |
Xenograft X1066 |
Mus musculus |
athymic nude mice |
|
|
| AZD1480 |
Inhibition of in vitro xenograft growth |
Western Blot |
30.00 mg/kg |
Xenograft X1046 |
Mus musculus |
athymic nude mice |
STAT3 |
|
| AZD1480 |
Inhibition of in vitro xenograft growth |
Western Blot |
30.00 mg/kg |
Xenograft X1046 |
Mus musculus |
athymic nude mice |
|
|
| AZD1480 |
Inhibition of in vitro xenograft growth |
Western Blot |
30.00 mg/kg |
Xenograft X1046 |
Mus musculus |
athymic nude mice |
|
|
| AZD1480 |
Inhibition of in vitro xenograft growth |
Western Blot |
30.00 mg/kg |
Xenograft X1046 |
Mus musculus |
athymic nude mice |
|
|
| AZD1480 |
Inhibition of in vitro xenograft growth |
Western Blot |
30.00 mg/kg |
Xenograft X1046 |
Mus musculus |
athymic nude mice |
|
|
| AZD1480 |
Inhibition of in vitro xenograft growth |
Western Blot |
30.00 mg/kg |
Xenograft X1046 |
Mus musculus |
athymic nude mice |
|
|
| AZD1480 |
Inhibition of in vitro xenograft growth |
Quantitative RT-PCR |
30.00 mg/kg |
Xenograft X1046 |
Mus musculus |
athymic nude mice |
|
|
| AZD1480 |
Inhibition of in vitro xenograft growth |
Tumor weight |
30.00 mg/kg |
Xenograft X1046 |
Mus musculus |
athymic nude mice |
|
|
| AZD1480 |
Influence on protein activity |
Immunoprecipitation |
30.00 nM |
CWR22Rv1 |
Homo sapiens |
|
STAT5A |
|
| AZD1480 |
Influence on protein activity |
Immunoprecipitation |
30.00 nM |
CWR22Rv1 |
Homo sapiens |
|
STAT5B |
|
| AZD1480 |
Influence on protein activity |
Immunoprecipitation |
30.00 nM |
CWR22Pc |
Homo sapiens |
|
STAT5A |
|
| AZD1480 |
Influence on protein activity |
Immunoprecipitation |
30.00 nM |
CWR22Pc |
Homo sapiens |
|
STAT5B |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
30.00 nM |
CWR22Rv1 |
Homo sapiens |
|
STAT5A |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
30.00 nM |
CWR22Rv1 |
Homo sapiens |
|
STAT5B |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
30.00 nM |
CWR22Pc |
Homo sapiens |
|
STAT5A |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
30.00 nM |
CWR22Pc |
Homo sapiens |
|
STAT5B |
|
| AZD1480 |
Influence on transcriptional activity of protein |
Luciferase Reporter Gene Assay |
30.00 nM |
PC-3 |
Homo sapiens |
|
STAT5A |
|
| AZD1480 |
Influence on transcriptional activity of protein |
Luciferase Reporter Gene Assay |
30.00 nM |
PC-3 |
Homo sapiens |
|
STAT5B |
|
