| AZD1480 |
Influence on apoptosis |
Flow cytometry- annexin V staining |
10.00 µM |
MO4 |
Mus musculus |
|
|
|
| AZD1480 |
Influence on apoptosis |
Flow cytometry- annexin V staining |
10.00 µM |
K1735-C4 |
Mus musculus |
|
|
|
| AZD1480 |
Influence on apoptosis |
Flow cytometry- annexin V staining |
10.00 µM |
1087-mel |
Mus musculus |
|
|
|
| AZD1480 |
Influence on cell proliferation in tumor tissue |
Tumor volume |
10.00 mg/kg |
MDAH2774 (xenograft) |
Mus musculus |
|
|
|
| AZD1480 |
Influence on kinase activity |
Cell-free kinase assay; Western Blot |
10.00 µM |
|
Homo sapiens |
|
p-STAT1 |
|
| AZD1480 |
Influence on kinase activity |
Cell-free kinase assay; Western Blot |
10.00 µM |
|
Homo sapiens |
|
STAT1 |
|
| AZD1480 |
Influence on kinase activity |
Cell-free kinase assay; Western Blot |
10.00 µM |
|
Homo sapiens |
|
|
|
| AZD1480 |
Influence on kinase activity |
Cell-free kinase assay; Western Blot |
10.00 µM |
|
Homo sapiens |
|
|
|
| AZD1480 |
Influence on cell proliferation |
WST-1 Cell Proliferation Assay |
10.00 µM |
U251-MG |
Homo sapiens |
|
|
|
| AZD1480 |
Influence on cell proliferation |
WST-1 Cell Proliferation Assay |
10.00 µM |
4C8 |
Homo sapiens |
|
|
|
| AZD1480 |
Influence on cell proliferation |
WST-1 Cell Proliferation Assay |
10.00 µM |
Murine Primary Astrocytes |
Mus musculus |
|
|
|
| AZD1480 |
Cell Apoptosis Analysis |
Flow cytometry- annexin V staining |
10.00 µM |
U251-MG |
Homo sapiens |
|
|
|
| AZD1480 |
Cell Apoptosis Analysis |
Western Blot |
10.00 µM |
U251-MG |
Homo sapiens |
|
|
|
| AZD1480 |
Cell Apoptosis Analysis |
Western Blot |
10.00 µM |
U251-MG |
Homo sapiens |
|
|
|
| AZD1480 |
Influence on cell motility |
Soft Agar Growth Assay |
10.00 µM |
U251-MG |
Homo sapiens |
|
|
|
| AZD1480 |
Influence on protein activity in presence of OSM |
Western Blot |
10.00 µM |
U251-MG |
Homo sapiens |
|
p-STAT3 (Y705) |
|
| AZD1480 |
Influence on protein activity in presence of OSM |
Western Blot |
10.00 µM |
U87-MG |
Homo sapiens |
|
p-STAT3 (Y705) |
|
| AZD1480 |
Influence on protein activity in presence of OSM |
Western Blot |
10.00 µM |
4C8 |
Homo sapiens |
|
p-STAT3 (Y705) |
|
| AZD1480 |
Influence on protein activity in presence of OSM |
Western Blot |
10.00 µM |
U251-MG |
Homo sapiens |
|
STAT3 |
|
| AZD1480 |
Influence on protein activity in presence of OSM |
Western Blot |
10.00 µM |
U87-MG |
Homo sapiens |
|
STAT3 |
|
| AZD1480 |
Influence on protein activity in presence of OSM |
Western Blot |
10.00 µM |
4C8 |
Homo sapiens |
|
STAT3 |
|
| AZD1480 |
Influence on protein activity in presence of OSM |
Western Blot |
10.00 µM |
U251-MG |
Homo sapiens |
|
|
|
| AZD1480 |
Influence on protein activity in presence of OSM |
Western Blot |
10.00 µM |
U87-MG |
Homo sapiens |
|
|
|
| AZD1480 |
Influence on protein activity in presence of OSM |
Western Blot |
10.00 µM |
4C8 |
Homo sapiens |
|
|
|
| AZD1480 |
Influence on protein activity in presence of OSM |
Western Blot |
10.00 µM |
U251-MG |
Homo sapiens |
|
|
|
| AZD1480 |
Influence on protein activity in presence of OSM |
Western Blot |
10.00 µM |
U87-MG |
Homo sapiens |
|
|
|
| AZD1480 |
Influence on protein activity in presence of OSM |
Western Blot |
10.00 µM |
4C8 |
Homo sapiens |
|
|
|
| AZD1480 |
Influence on protein activity in presence of OSM |
Western Blot |
10.00 µM |
U251-MG |
Homo sapiens |
|
|
|
| AZD1480 |
Influence on protein activity in presence of OSM |
Western Blot |
10.00 µM |
U251-MG |
Homo sapiens |
|
|
|
| AZD1480 |
Influence on protein activity in presence of OSM |
Western Blot |
10.00 µM |
U87-MG |
Homo sapiens |
|
|
|
| AZD1480 |
Influence on protein activity in presence of OSM |
Western Blot |
10.00 µM |
4C8 |
Homo sapiens |
|
|
|
| AZD1480 |
Influence on protein activity in presence of OSM |
Western Blot |
10.00 µM |
U251-MG |
Homo sapiens |
|
|
|
| AZD1480 |
Influence on protein activity in tumor tissue in presence of OSM |
Western Blot |
10.00 µM |
Xenograft X1066 |
Mus musculus |
athymic nude mice |
p-STAT3 (Y705) |
|
| AZD1480 |
Influence on protein activity in tumor tissue in presence of OSM |
Western Blot |
10.00 µM |
Xenograft X1066 |
Mus musculus |
athymic nude mice |
STAT3 |
|
| AZD1480 |
Influence on protein activity in tumor tissue in presence of OSM |
Western Blot |
10.00 µM |
Xenograft X1066 |
Mus musculus |
athymic nude mice |
|
|
| AZD1480 |
Influence on protein activity in tumor tissue in presence of OSM |
Western Blot |
10.00 µM |
Xenograft X1066 |
Mus musculus |
athymic nude mice |
|
|
| AZD1480 |
Influence on protein activity in tumor tissue in presence of OSM |
Western Blot |
10.00 µM |
Xenograft X1066 |
Mus musculus |
athymic nude mice |
|
|
| AZD1480 |
Influence on protein activity in tumor tissue in presence of OSM |
Western Blot |
10.00 µM |
Xenograft X1066 |
Mus musculus |
athymic nude mice |
|
|
| AZD1480 |
Influence on protein activity in tumor tissue in presence of OSM |
Western Blot |
10.00 µM |
Xenograft X1066 |
Mus musculus |
athymic nude mice |
|
|
| AZD1480 |
Inhibition of cell proliferation in xenograft tumors |
WST-1 Cell Proliferation Assay |
10.00 µM |
Xenograft X1016 |
Mus musculus |
athymic nude mice |
|
|
| AZD1480 |
Influence on cell viability |
AlamarBlue assay |
10.00 µM |
PAKRSL |
|
|
|
|
| AZD1480 |
Influence on protein activity |
Immunoprecipitation |
10.00 nM |
CWR22Rv1 |
Homo sapiens |
|
STAT5A |
|
| AZD1480 |
Influence on protein activity |
Immunoprecipitation |
10.00 nM |
CWR22Rv1 |
Homo sapiens |
|
STAT5B |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
10.00 nM |
CWR22Rv1 |
Homo sapiens |
|
STAT5A |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
10.00 nM |
CWR22Rv1 |
Homo sapiens |
|
STAT5B |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
10.00 nM |
CWR22Pc |
Homo sapiens |
|
STAT5A |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
10.00 nM |
CWR22Pc |
Homo sapiens |
|
STAT5B |
|
| AZD1480 |
Influence on transcriptional activity of protein |
Luciferase Reporter Gene Assay |
10.00 nM |
PC-3 |
Homo sapiens |
|
STAT5A |
|
| AZD1480 |
Influence on transcriptional activity of protein |
Luciferase Reporter Gene Assay |
10.00 nM |
PC-3 |
Homo sapiens |
|
STAT5B |
|
| AZD1480 |
Influence on cell proliferation in tumor tissue |
Tumour volume |
10.00 mg/kg |
CWR22Rv1 |
Mus musculus |
|
|
|
