| AZD1480 |
Influence on protein activity in presence of OSM |
Western Blot |
0.10 µM |
MEF-Stat3-YFP |
Mus musculus |
|
|
|
| AZD1480 |
Influence on protein translocation in presence of OSM |
Immunofluorescence |
0.10 µM |
MEF-Stat3-YFP |
Mus musculus |
|
STAT3 |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
0.10 µM |
LN-17 |
Homo sapiens |
|
p-STAT3 (Y705) |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
0.10 µM |
LN-17 |
Homo sapiens |
|
|
|
| AZD1480 |
Influence on protein-DNA interaction |
EMSA |
0.10 µM |
LN-17 |
Homo sapiens |
|
STAT3:STAT3 |
|
| AZD1480 |
Influence on cell viability |
MTS Assay |
0.10 µM |
LN-17 |
Homo sapiens |
|
|
|
| AZD1480 |
Influence on cell apoptosis |
Flow cytometry- annexin V staining |
0.10 µM |
LN-17 |
Homo sapiens |
|
|
|
| AZD1480 |
Influence on cell apoptosis |
Western Blot |
0.10 µM |
LN-17 |
Homo sapiens |
|
|
|
| AZD1480 |
Influence on cell apoptosis |
Western Blot |
0.10 µM |
LN-17 |
Homo sapiens |
|
|
|
| AZD1480 |
Influence on protein activity |
Western Blot |
0.10 µM |
MDAH2774 |
Homo sapiens |
|
p-STAT3 (Y705) |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
0.10 µM |
MDAH2774 |
Homo sapiens |
|
STAT3 |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
0.10 µM |
MDAH2774 |
Homo sapiens |
|
|
|
| AZD1480 |
Influence on protein activity |
Western Blot |
0.10 µM |
MDA-MB-468 |
Homo sapiens |
|
p-STAT3 (Y705) |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
0.10 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
| AZD1480 |
Influence on protein activity |
Western Blot |
0.10 µM |
DU145 |
Homo sapiens |
|
p-STAT3 (Y705) |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
0.10 µM |
DU145 |
Homo sapiens |
|
STAT3 |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
0.10 µM |
DU145 |
Homo sapiens |
|
|
|
| AZD1480 |
Influence on protein activity in presence of IL-6 |
Western Blot |
0.10 µM |
MDA-MB-468 |
Homo sapiens |
|
p-STAT3 (Y705) |
|
| AZD1480 |
Influence on protein activity in presence of IL-6 |
Western Blot |
0.10 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
| AZD1480 |
Influence on protein activity in presence of IL-6 |
Western Blot |
0.10 µM |
DU145 |
Homo sapiens |
|
p-STAT3 (Y705) |
|
| AZD1480 |
Influence on protein activity in presence of IL-6 |
Western Blot |
0.10 µM |
DU145 |
Homo sapiens |
|
|
|
| AZD1480 |
Influence on cell motility |
Tube formation assay |
0.10 µM |
EC |
Mus musclus |
BALB/c |
|
|
| AZD1480 |
Influence on cell motility |
Tube formation assay |
0.10 µM |
HUVEC |
Homo sapiens |
BALB/c |
|
|
| AZD1480 |
Influence on kinase activity |
Cell-free kinase assay; Western Blot |
0.10 µM |
|
Homo sapiens |
|
p-STAT1 |
|
| AZD1480 |
Influence on kinase activity |
Cell-free kinase assay; Western Blot |
0.10 µM |
|
Homo sapiens |
|
STAT1 |
|
| AZD1480 |
Influence on protein activity in presence of OSM |
Western Blot |
0.10 µM |
U251-MG |
Homo sapiens |
|
p-STAT3 (Y705) |
|
| AZD1480 |
Influence on protein activity in presence of OSM |
Western Blot |
0.10 µM |
U87-MG |
Homo sapiens |
|
p-STAT3 (Y705) |
|
| AZD1480 |
Influence on protein activity in presence of OSM |
Western Blot |
0.10 µM |
4C8 |
Homo sapiens |
|
p-STAT3 (Y705) |
|
| AZD1480 |
Influence on protein activity in presence of OSM |
Western Blot |
0.10 µM |
U251-MG |
Homo sapiens |
|
STAT3 |
|
| AZD1480 |
Influence on protein activity in presence of OSM |
Western Blot |
0.10 µM |
U87-MG |
Homo sapiens |
|
STAT3 |
|
| AZD1480 |
Influence on protein activity in presence of OSM |
Western Blot |
0.10 µM |
4C8 |
Homo sapiens |
|
STAT3 |
|
| AZD1480 |
Influence on protein activity in presence of OSM |
Western Blot |
0.10 µM |
U251-MG |
Homo sapiens |
|
|
|
| AZD1480 |
Influence on protein activity in presence of OSM |
Western Blot |
0.10 µM |
U87-MG |
Homo sapiens |
|
|
|
| AZD1480 |
Influence on protein activity in presence of OSM |
Western Blot |
0.10 µM |
4C8 |
Homo sapiens |
|
|
|
| AZD1480 |
Influence on protein activity in presence of OSM |
Western Blot |
0.10 µM |
U87-MG |
Homo sapiens |
|
|
|
| AZD1480 |
Influence on protein activity in presence of OSM |
Western Blot |
0.10 µM |
4C8 |
Homo sapiens |
|
|
|
| AZD1480 |
Influence on protein activity in presence of OSM |
Western Blot |
0.10 µM |
U251-MG |
Homo sapiens |
|
|
|
| AZD1480 |
Influence on protein activity in presence of OSM |
Western Blot |
0.10 µM |
U251-MG |
Homo sapiens |
|
|
|
| AZD1480 |
Influence on protein activity in presence of OSM |
Western Blot |
0.10 µM |
U87-MG |
Homo sapiens |
|
|
|
| AZD1480 |
Influence on protein activity in presence of OSM |
Western Blot |
0.10 µM |
4C8 |
Homo sapiens |
|
|
|
| AZD1480 |
Influence on protein activity in presence of OSM |
Western Blot |
0.10 µM |
U251-MG |
Homo sapiens |
|
|
|
| AZD1480 |
Influence on protein activity in tumor tissue in presence of OSM |
Western Blot |
0.10 µM |
Xenograft X1066 |
Mus musculus |
athymic nude mice |
p-STAT3 (Y705) |
|
| AZD1480 |
Influence on protein activity in tumor tissue in presence of OSM |
Western Blot |
0.10 µM |
Xenograft X1066 |
Mus musculus |
athymic nude mice |
STAT3 |
|
| AZD1480 |
Influence on protein activity in tumor tissue in presence of OSM |
Western Blot |
0.10 µM |
Xenograft X1066 |
Mus musculus |
athymic nude mice |
|
|
| AZD1480 |
Influence on protein activity in tumor tissue in presence of OSM |
Western Blot |
0.10 µM |
Xenograft X1066 |
Mus musculus |
athymic nude mice |
|
|
| AZD1480 |
Influence on protein activity in tumor tissue in presence of OSM |
Western Blot |
0.10 µM |
Xenograft X1066 |
Mus musculus |
athymic nude mice |
|
|
| AZD1480 |
Influence on protein activity in tumor tissue in presence of OSM |
Western Blot |
0.10 µM |
Xenograft X1066 |
Mus musculus |
athymic nude mice |
|
|
| AZD1480 |
Influence on protein activity in tumor tissue in presence of OSM |
Western Blot |
0.10 µM |
Xenograft X1066 |
Mus musculus |
athymic nude mice |
|
|
