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Experiments

Compound Investigated event Experiment type Concentration Cell line Organism Animal model Stat protein Details
AZD1480 Influence on protein activity Western Blot 0.10 µM MDA-MB-468 Homo sapiens p-STAT3 (Y705)
AZD1480 Influence on protein activity Western Blot 0.50 µM MDA-MB-468 Homo sapiens p-STAT3 (Y705)
AZD1480 Influence on protein activity Western Blot 1.00 µM MDA-MB-468 Homo sapiens p-STAT3 (Y705)
AZD1480 Influence on protein activity Western Blot 0.10 µM MDA-MB-468 Homo sapiens
AZD1480 Influence on protein activity Western Blot 0.50 µM MDA-MB-468 Homo sapiens
AZD1480 Influence on protein activity Western Blot 1.00 µM MDA-MB-468 Homo sapiens
AZD1480 Influence on protein activity in presence of IL-6 Western Blot 0.10 µM MDA-MB-468 Homo sapiens p-STAT3 (Y705)
AZD1480 Influence on protein activity in presence of IL-6 Western Blot 0.50 µM MDA-MB-468 Homo sapiens p-STAT3 (Y705)
AZD1480 Influence on protein activity in presence of IL-6 Western Blot 1.00 µM MDA-MB-468 Homo sapiens p-STAT3 (Y705)
AZD1480 Influence on protein activity in presence of IL-6 Western Blot 0.10 µM MDA-MB-468 Homo sapiens
AZD1480 Influence on protein activity in presence of IL-6 Western Blot 0.50 µM MDA-MB-468 Homo sapiens
AZD1480 Influence on protein activity in presence of IL-6 Western Blot 1.00 µM MDA-MB-468 Homo sapiens
AZD1480 Influence on cell proliferation in tumor tissue Tumor volume 50.00 mg/kg MDA-MB-468 (xenograft) Mus musculus
AZD1480 Influence on protein activity in tumor tissue Western Blot 50.00 mg/kg MDA-MB-468 (xenograft) Mus musculus p-STAT3 (Y705)
AZD1480 Influence on protein activity in tumor tissue Western Blot 50.00 mg/kg MDA-MB-468 (xenograft) Mus musculus STAT3
AZD1480 Influence on protein activity in tumor tissue Western Blot 50.00 mg/kg MDA-MB-468 (xenograft) Mus musculus