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Experiments

Compound Investigated event Experiment type Concentration Cell line Organism Animal model Stat protein Details
S3I-M2001 Influence on protein binding to DNA EMSA 10.00 µM MDA-MB-231 Homo sapiens STAT3:STAT3
S3I-M2001 Influence on protein binding to DNA EMSA 30.00 µM MDA-MB-231 Homo sapiens STAT3:STAT3
S3I-M2001 Influence on protein binding to DNA EMSA 100.00 µM MDA-MB-231 Homo sapiens STAT3:STAT3
S3I-M2001 Influence on protein binding to DNA EMSA 300.00 µM MDA-MB-231 Homo sapiens STAT3:STAT3
S3I-M2001 Influence on cell proliferation WST-1 50.00 µM MDA-MB-231 Homo sapiens
S3I-M2001 Influence on cell proliferation WST-1 100.00 µM MDA-MB-231 Homo sapiens
S3I-M2001 Influence on cell proliferation WST-1 150.00 µM MDA-MB-231 Homo sapiens
S3I-M2001 Influence on cell proliferation WST-1 200.00 µM MDA-MB-231 Homo sapiens
S3I-M2001 Influence on cell proliferation WST-1 250.00 µM MDA-MB-231 Homo sapiens
S3I-M2001 Influence on cell proliferation WST-1 300.00 µM MDA-MB-231 Homo sapiens
S3I-M2001 Influence on cell proliferation WST-1 350.00 µM MDA-MB-231 Homo sapiens
S3I-M2001 Influence on DNA TUNEL 50.00 µM MDA-MB-231 Homo sapiens
S3I-M2001 Influence on cell motility Migration assay 100.00 µM MDA-MB-231 Homo sapiens
S3I-M2001 Influence on tumor growth Tumor volume 5.00 mg/kg MDA-MB-231 (xenograft) Mus musculus athymic nude mice
S3I-M2001 Influence on tumor growth Tumor volume 10.00 mg/kg MDA-MB-231 (xenograft) Mus musculus athymic nude mice
S3I-M2001 Influence on tumor growth Tumor volume 20.00 mg/kg MDA-MB-231 (xenograft) Mus musculus athymic nude mice
S3I-M2001 Influence on DNA binding in tumor EMSA 5.00 mg/kg MDA-MB-231 (xenograft) Mus musculus athymic nude mice STAT3:STAT3
S3I-M2001 Influence on protein activity in tumor tissue Western Blot 5.00 mg/kg MDA-MB-231 (xenograft) Mus musculus athymic nude mice STAT3
S3I-M2001 Influence on protein activity in tumor tissue Western Blot 5.00 mg/kg MDA-MB-231 (xenograft) Mus musculus athymic nude mice p-STAT3(Y705)