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Experiments

Compound Investigated event Experiment type Concentration Cell line Organism Animal model Stat protein Details
AZD1480 Influence on STAT3 downstream genes Western Blot 2.50 µM KCNR Homo sapiens
AZD1480 Influence on STAT3 downstream genes Western Blot 5.00 µM KCNR Homo sapiens
AZD1480 Influence on STAT3 downstream genes Western Blot 0.50 µM KCNR Homo sapiens
AZD1480 Influence on STAT3 downstream genes Western Blot 1.00 µM KCNR Homo sapiens
AZD1480 Influence on STAT3 downstream genes Western Blot 2.50 µM KCNR Homo sapiens
AZD1480 Influence on STAT3 downstream genes Western Blot 5.00 µM KCNR Homo sapiens
AZD1480 Influence on STAT3 downstream genes Western Blot 0.50 µM KCNR Homo sapiens
AZD1480 Influence on STAT3 downstream genes Western Blot 1.00 µM KCNR Homo sapiens
AZD1480 Influence on STAT3 downstream genes Western Blot 2.50 µM KCNR Homo sapiens
AZD1480 Influence on STAT3 downstream genes Western Blot 5.00 µM KCNR Homo sapiens
AZD1480 Influence on STAT3 downstream genes Western Blot 0.50 µM KCNR Homo sapiens
AZD1480 Influence on STAT3 downstream genes Western Blot 1.00 µM KCNR Homo sapiens
AZD1480 Influence on STAT3 downstream genes Western Blot 2.50 µM KCNR Homo sapiens
AZD1480 Influence on STAT3 downstream genes Western Blot 5.00 µM KCNR Homo sapiens
AZD1480 Influence on STAT3 downstream genes Real Time PCR 0.50 µM KCNR Homo sapiens
AZD1480 Influence on STAT3 downstream genes Real Time PCR 0.50 µM KCNR Homo sapiens
AZD1480 Influence on STAT3 downstream genes Real Time PCR 0.50 µM KCNR Homo sapiens
AZD1480 Influence on STAT3 downstream genes Real Time PCR 0.50 µM KCNR Homo sapiens
AZD1480 Influence on STAT3 downstream genes Real Time PCR 0.50 µM KCNR Homo sapiens
AZD1480 Influence on STAT3 downstream genes Real Time PCR 0.50 µM KCNR Homo sapiens
AZD1480 Influence on tumor growth Tumer volume 30.00 mg/kg KCNR (xenograft) Mus musculus athymic nude mice
AZD1480 Influence on protein activity in tumor tissue Western Blot 30.00 mg/kg KCNR (xenograft) Mus musculus athymic nude mice p-STAT3 (Y705)
AZD1480 Influence on protein activity in tumor tissue Western Blot 30.00 mg/kg KCNR (xenograft) Mus musculus athymic nude mice STAT3
AZD1480 Influence on protein activity in tumor tissue Western Blot 30.00 mg/kg KCNR (xenograft) Mus musculus athymic nude mice
AZD1480 Influence on protein activity in tumor tissue Western Blot 30.00 mg/kg KCNR (xenograft) Mus musculus athymic nude mice
AZD1480 Influence on protein activity in tumor tissue Western Blot 30.00 mg/kg KCNR (xenograft) Mus musculus athymic nude mice
AZD1480 Influence on protein activity in tumor tissue Western Blot 30.00 mg/kg KCNR (xenograft) Mus musculus athymic nude mice
AZD1480 Influence on protein activity in tumor tissue Western Blot 30.00 mg/kg KCNR (xenograft) Mus musculus athymic nude mice
AZD1480 Influence on late protein activity in tumor tissue Western Blot 30.00 mg/kg KCNR (xenograft) Mus musculus athymic nude mice p-STAT3 (Y705)
AZD1480 Influence on late protein activity in tumor tissue Western Blot 30.00 mg/kg KCNR (xenograft) Mus musculus athymic nude mice STAT3
AZD1480 Influence on late protein activity in tumor tissue Western Blot 30.00 mg/kg KCNR (xenograft) Mus musculus athymic nude mice
AZD1480 Influence on late protein activity in tumor tissue Western Blot 30.00 mg/kg KCNR (xenograft) Mus musculus athymic nude mice
AZD1480 Influence on late protein activity in tumor tissue Western Blot 30.00 mg/kg KCNR (xenograft) Mus musculus athymic nude mice
AZD1480 Influence on late protein activity in tumor tissue Western Blot 30.00 mg/kg KCNR (xenograft) Mus musculus athymic nude mice
AZD1480 Influence on late protein activity in tumor tissue Western Blot 30.00 mg/kg KCNR (xenograft) Mus musculus athymic nude mice
AZD1480 Influence on tumor growth Histological staining 30.00 mg/kg KCNR (xenograft) Mus musculus athymic nude mice