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Experiments

Compound Investigated event Experiment type Concentration Cell line Organism Animal model Stat protein Details
AZD1480 Influence on protein activity Western Blot 0.10 µM DU145 Homo sapiens p-STAT3 (Y705)
AZD1480 Influence on protein activity Western Blot 0.25 µM DU145 Homo sapiens p-STAT3 (Y705)
AZD1480 Influence on protein activity Western Blot 0.50 µM DU145 Homo sapiens p-STAT3 (Y705)
AZD1480 Influence on protein activity Western Blot 1.00 µM DU145 Homo sapiens p-STAT3 (Y705)
AZD1480 Influence on protein activity Western Blot 0.10 µM DU145 Homo sapiens STAT3
AZD1480 Influence on protein activity Western Blot 0.25 µM DU145 Homo sapiens STAT3
AZD1480 Influence on protein activity Western Blot 0.50 µM DU145 Homo sapiens STAT3
AZD1480 Influence on protein activity Western Blot 1.00 µM DU145 Homo sapiens STAT3
AZD1480 Influence on protein activity Western Blot 0.10 µM DU145 Homo sapiens
AZD1480 Influence on protein activity Western Blot 0.25 µM DU145 Homo sapiens
AZD1480 Influence on protein activity Western Blot 0.50 µM DU145 Homo sapiens
AZD1480 Influence on protein activity Western Blot 1.00 µM DU145 Homo sapiens
AZD1480 Influence on protein activity in presence of IL-6 Western Blot 0.10 µM DU145 Homo sapiens p-STAT3 (Y705)
AZD1480 Influence on protein activity in presence of IL-6 Western Blot 0.50 µM DU145 Homo sapiens p-STAT3 (Y705)
AZD1480 Influence on protein activity in presence of IL-6 Western Blot 1.00 µM DU145 Homo sapiens p-STAT3 (Y705)
AZD1480 Influence on protein activity in presence of IL-6 Western Blot 0.10 µM DU145 Homo sapiens
AZD1480 Influence on protein activity in presence of IL-6 Western Blot 0.50 µM DU145 Homo sapiens
AZD1480 Influence on protein activity in presence of IL-6 Western Blot 1.00 µM DU145 Homo sapiens
AZD1480 Influence on cell proliferation MTS Assay 1.00 µM DU145 Homo sapiens
AZD1480 Influence on cell proliferation in tumor tissue Tumor volume 50.00 mg/kg DU145 (xenograft) Mus musculus
AZD1480 Influence on protein activity in tumor tissue Western Blot 50.00 mg/kg DU145 (xenograft) Mus musculus p-STAT3 (Y705)
AZD1480 Influence on protein activity in tumor tissue Western Blot 50.00 mg/kg DU145 (xenograft) Mus musculus