| AZD1480 |
|
Function of myeloid-derived suppressor cells |
30.00 mg/kg |
MO4 (xenograft) |
Mus musculus |
c57BL/6 |
|
|
| AZD1480 |
Influence on cell differentiation |
Flow cytometry |
0.25 µM |
Th1 |
Mus musculus |
c57BL/6 |
STAT1 |
|
| AZD1480 |
Influence on cell differentiation |
Flow cytometry |
0.25 µM |
Th1 |
Mus musculus |
c57BL/6 |
STAT4 |
|
| AZD1480 |
Influence on cytokine secretion |
Flow cytometry |
0.25 µM |
Th1 |
Mus musculus |
c57BL/6 |
|
|
| AZD1480 |
Influence on cytokine secretion |
RT-qPCR |
0.25 µM |
Th1 |
Mus musculus |
c57BL/6 |
|
|
| AZD1480 |
Influence on protein activity |
Flow cytometry |
0.25 µM |
Th1 |
Mus musculus |
c57BL/6 |
STAT3 |
|
| AZD1480 |
|
Quantitative RT-PCR |
0.25 µM |
Th1 |
Mus musculus |
c57BL/6 |
|
|
| AZD1480 |
Influence on protein activity |
Western Blot |
0.50 µM |
BMDM |
Mus musculus |
c57BL/6 |
STAT1 |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
1.00 µM |
BMDM |
Mus musculus |
c57BL/6 |
STAT1 |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
2.00 µM |
BMDM |
Mus musculus |
c57BL/6 |
STAT1 |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
4.00 µM |
BMDM |
Mus musculus |
c57BL/6 |
STAT1 |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
0.50 µM |
BMDM |
Mus musculus |
c57BL/6 |
STAT3 |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
1.00 µM |
BMDM |
Mus musculus |
c57BL/6 |
STAT3 |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
2.00 µM |
BMDM |
Mus musculus |
c57BL/6 |
STAT3 |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
4.00 µM |
BMDM |
Mus musculus |
c57BL/6 |
STAT3 |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
0.25 µM |
BMDM |
Mus musculus |
c57BL/6 |
STAT5 |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
0.50 µM |
BMDM |
Mus musculus |
c57BL/6 |
STAT5 |
|
| AZD1480 |
Influence on protein activity in presence of IL-6 |
Western Blot |
0.50 µM |
BMDM |
Mus musculus |
c57BL/6 |
STAT3 |
|
| AZD1480 |
Influence on protein activity in presence of IL-6 |
Western Blot |
1.00 µM |
BMDM |
Mus musculus |
c57BL/6 |
STAT3 |
|
| AZD1480 |
Influence on protein activity in presence of IL-6 |
Western Blot |
2.00 µM |
BMDM |
Mus musculus |
c57BL/6 |
STAT3 |
|
| AZD1480 |
Influence on protein activity in presence of IL-6 |
Western Blot |
4.00 µM |
BMDM |
Mus musculus |
c57BL/6 |
STAT3 |
|
| AZD1480 |
Influence on protein activity in presence of IL-6 |
Western Blot |
0.50 µM |
BMDM |
Mus musculus |
c57BL/6 |
|
|
| AZD1480 |
Influence on protein activity in presence of IL-6 |
Western Blot |
1.00 µM |
BMDM |
Mus musculus |
c57BL/6 |
|
|
| AZD1480 |
Influence on protein activity in presence of IL-6 |
Western Blot |
2.00 µM |
BMDM |
Mus musculus |
c57BL/6 |
|
|
| AZD1480 |
Influence on protein activity in presence of IL-6 |
Western Blot |
4.00 µM |
BMDM |
Mus musculus |
c57BL/6 |
|
|
| AZD1480 |
Influence on protein activity in presence of IL-6 |
Western Blot |
0.50 µM |
BMDM |
Mus musculus |
c57BL/6 |
|
|
| AZD1480 |
Influence on protein activity in presence of IL-6 |
Western Blot |
1.00 µM |
BMDM |
Mus musculus |
c57BL/6 |
|
|
| AZD1480 |
Influence on protein activity in presence of IL-6 |
Western Blot |
2.00 µM |
BMDM |
Mus musculus |
c57BL/6 |
|
|
| AZD1480 |
Influence on protein activity in presence of IL-6 |
Western Blot |
4.00 µM |
BMDM |
Mus musculus |
c57BL/6 |
|
|
| AZD1480 |
Influence on protein activity in presence of IL-6 |
Western Blot |
0.50 µM |
BMDM |
Mus musculus |
c57BL/6 |
STAT1 |
|
| AZD1480 |
Influence on protein activity in presence of IL-6 |
Western Blot |
1.00 µM |
BMDM |
Mus musculus |
c57BL/6 |
STAT1 |
|
| AZD1480 |
Influence on protein activity in presence of IL-6 |
Western Blot |
2.00 µM |
BMDM |
Mus musculus |
c57BL/6 |
STAT1 |
|
| AZD1480 |
Influence on protein activity in presence of IL-6 |
Western Blot |
4.00 µM |
BMDM |
Mus musculus |
c57BL/6 |
STAT1 |
|
| AZD1480 |
Influence on nitrite production |
Griess |
0.25 µM |
BMDM |
Mus musculus |
c57BL/6 |
|
|
| AZD1480 |
Influence on MHC expression |
Flow cytometry |
0.25 µM |
DCs |
Mus musculus |
c57BL/6 |
|
|
| AZD1480 |
Influence on MHC expression |
Flow cytometry |
0.50 µM |
DCs |
Mus musculus |
c57BL/6 |
|
|
| AZD1480 |
Influence on cell proliferation |
Flow cytometry |
25.00 mg/kg |
CD4+T |
Mus musculus |
c57BL/6 |
|
|
| AZD1480 |
Influence on cell proliferation |
Flow cytometry |
50.00 mg/kg |
CD4+T |
Mus musculus |
c57BL/6 |
|
|
| AZD1480 |
Influence on cell proliferation |
Flow cytometry |
100.00 mg/kg |
CD4+T |
Mus musculus |
c57BL/6 |
|
|
| AZD1480 |
Influence on hematologic parameters |
HEMAVET |
25.00 mg/kg |
RBC |
Mus musculus |
c57BL/6 |
|
|
| AZD1480 |
Influence on hematologic parameters |
HEMAVET |
50.00 mg/kg |
RBC |
Mus musculus |
c57BL/6 |
|
|
| AZD1480 |
Influence on hematologic parameters |
HEMAVET |
25.00 mg/kg |
WBC |
Mus musculus |
c57BL/6 |
|
|
| AZD1480 |
Influence on hematologic parameters |
HEMAVET |
50.00 mg/kg |
WBC |
Mus musculus |
c57BL/6 |
|
|
| AZD1480 |
Influence on hematologic parameters |
HEMAVET |
25.00 mg/kg |
NEU |
Mus musculus |
c57BL/6 |
|
|
| AZD1480 |
Influence on hematologic parameters |
HEMAVET |
50.00 mg/kg |
NEU |
Mus musculus |
c57BL/6 |
|
|
| AZD1480 |
Influence on hematologic parameters |
HEMAVET |
25.00 mg/kg |
LYM |
Mus musculus |
c57BL/6 |
|
|
| AZD1480 |
Influence on hematologic parameters |
HEMAVET |
50.00 mg/kg |
LYM |
Mus musculus |
c57BL/6 |
|
|
| AZD1480 |
Influence on hematologic parameters |
HEMAVET |
25.00 mg/kg |
MONO |
Mus musculus |
c57BL/6 |
|
|
| AZD1480 |
Influence on hematologic parameters |
HEMAVET |
50.00 mg/kg |
MONO |
Mus musculus |
c57BL/6 |
|
|
| AZD1480 |
Influence on protein activity |
Immunization |
25.00 mg/kg |
|
Mus musculus |
c57BL/6 |
|
|
