Investigated event: Influence on tubulointerstitial fibrosis
| Name | Value |
|---|---|
| Compound | Paclitaxel |
| Investigated event | Influence on tubulointerstitial fibrosis |
| Experiment type | Immunohistochemistry |
| Concentration | 0.30 mg/kg |
| Cell line | kidney tissue |
| Organism | Mus musculus |
| Animal model | C57BL/6 (UUO) |
| STAT protein | p-STAT3 |
| Other |
Reference
Paclitaxel attenuates renal interstitial fibroblast activation and interstitial fibrosis by inhibiting STAT3 signaling. Drug design, development and therapy Lei Zhang, Xuan Xu, Ruhao Yang, Jingwen Chen, Shixuan Wang, Junqin Yang, Xudong Xiang, Zhibiao He, Yu Zhao, Zheng Dong, Dongshan Zhang, 9, None, None, 2015-04-15, 10.2147/DDDT.S81390
DOI: 10.2147/DDDT.S81390
PUBMED: 25931810
PMCID: PMC4404961