Investigated event: Influence on protein activity in presence of IL-6
| Name | Value |
|---|---|
| Compound | LLL-12 |
| Investigated event | Influence on protein activity in presence of IL-6 |
| Experiment type | Western Blot |
| Concentration | 5.00 µM |
| Cell line | SJSA |
| Organism | Homo sapiens |
| Animal model | |
| STAT protein | p-STAT3 (Y705) |
| Other |
Reference
Small molecules, LLL12 and FLLL32, inhibit STAT3 and exhibit potent growth suppressive activity in osteosarcoma cells and tumor growth in mice. Investigational new drugs Grace-Ifeyinwa Onimoe, Aiguo Liu, Li Lin, Chang-Ching Wei, Eric B Schwartz, Deepak Bhasin, Chenglong Li, James R Fuchs, Pui-kai Li, Peter Houghton, Amanda Termuhlen, Thomas Gross, Jiayuh Lin, 30, 3, None, 2011-02-22, 10.1007/s10637-011-9645-1
DOI: 10.1007/s10637-011-9645-1
PUBMED: 21340507
PMCID: 21340507