Investigated event: Influence on protein activity
Name | Value |
---|---|
Compound | LLL-12 |
Investigated event | Influence on protein activity |
Experiment type | Western Blot |
Concentration | 5.00 µM |
Cell line | SJSA |
Organism | Homo sapiens |
Animal model | |
STAT protein | p-STAT3 (Y705) |
Other |
Reference
Small molecules, LLL12 and FLLL32, inhibit STAT3 and exhibit potent growth suppressive activity in osteosarcoma cells and tumor growth in mice. Investigational new drugs Grace-Ifeyinwa Onimoe, Aiguo Liu, Li Lin, Chang-Ching Wei, Eric B Schwartz, Deepak Bhasin, Chenglong Li, James R Fuchs, Pui-kai Li, Peter Houghton, Amanda Termuhlen, Thomas Gross, Jiayuh Lin, 30, 3, None, 2011-02-22, 10.1007/s10637-011-9645-1
DOI: 10.1007/s10637-011-9645-1
PUBMED:
21340507
PMCID: 21340507