Investigated event:
| Name | Value |
|---|---|
| Compound | AG490 |
| Investigated event | |
| Experiment type | RT-qPCR |
| Concentration | 25.00 μM/L |
| Cell line | Pancreatic Acinar Cells |
| Organism | Rattus norvegicus |
| Animal model | Sprague-Dawley (SD) rats |
| STAT protein | STAT3 |
| Other |
Reference
High mobility group box 1 induces the activation of the Janus kinase 2 and signal transducer and activator of transcription 3 (JAK2/STAT3) signaling pathway in pancreatic acinar cells in rats, while AG490 and rapamycin inhibit their activation. Bosnian journal of basic medical sciences Guoliang Wang, Jingchao Zhang, Danhua Dui, Haoyuan Ren, Jin Liu, 16, 4, 2016-11-10, 2016-11-10, 10.17305/bjbms.2016.1442
DOI: 10.17305/bjbms.2016.1442
PUBMED: 27754827
PMCID: PMC5136768