Investigated event: Influence on protein activity

Name Value
Compound E738
Investigated event Influence on protein activity
Experiment type Western Blot
Concentration 2.50 µM
Cell line MIA-PaCa2
Organism Homo sapiens
Animal model
STAT protein
Other p-JAK2 (Tyr1007/1008)
Reference
Dual inhibition of Janus and Src family kinases by novel indirubin derivative blocks constitutively-activated Stat3 signaling associated with apoptosis of human pancreatic cancer cells. Molecular oncology Sangkil Nam, Wei Wen, Anne Schroeder, Andreas Herrmann, Hua Yu, Xinlai Cheng, Karl-Heinz Merz, Gerhard Eisenbrand, Hongzhi Li, Yate-Ching Yuan, Richard Jove, 7, 3, None, 2012-11-16, 10.1016/j.molonc.2012.10.013 DOI: 10.1016/j.molonc.2012.10.013 PUBMED: 23206899 PMCID: PMC3968804