Investigated event: Influence on kinase activity

Name Value
Compound E738
Investigated event Influence on kinase activity
Experiment type Kinase activity assay
Concentration 10.40 nM
Cell line
Organism Homo sapiens
Animal model
STAT protein
Other JAK1
Reference
Dual inhibition of Janus and Src family kinases by novel indirubin derivative blocks constitutively-activated Stat3 signaling associated with apoptosis of human pancreatic cancer cells. Molecular oncology Sangkil Nam, Wei Wen, Anne Schroeder, Andreas Herrmann, Hua Yu, Xinlai Cheng, Karl-Heinz Merz, Gerhard Eisenbrand, Hongzhi Li, Yate-Ching Yuan, Richard Jove, 7, 3, None, 2012-11-16, 10.1016/j.molonc.2012.10.013 DOI: 10.1016/j.molonc.2012.10.013 PUBMED: 23206899 PMCID: PMC3968804