Investigated event: Measurement of IC50 value JAKs-JH1 truncated kinases

Name Value
Compound Brevilin A
Investigated event Measurement of IC50 value JAKs-JH1 truncated kinases
Experiment type Western Blot
Concentration 20.00 µM
Cell line HEK293T (Tyk2-JH1)
Organism Homo sapiens
Animal model
STAT protein pTyr705-STAT3
Other
Reference
Brevilin A, a novel natural product, inhibits janus kinase activity and blocks STAT3 signaling in cancer cells. PloS one Xing Chen, Yuping Du, Jing Nan, Xinxin Zhang, Xiaodong Qin, Yuxin Wang, Jianwen Hou, Qin Wang, Jinbo Yang, 8, 5, None, 2013-05-21, 10.1371/journal.pone.0063697 DOI: 10.1371/journal.pone.0063697 PUBMED: 23704931 PMCID: PMC3660600