Investigated event: Influence on JAK2 phosphorylation

Name Value
Compound BBMD3 (berbamine derivative)
Investigated event Influence on JAK2 phosphorylation
Experiment type Autophosphorylation kinase activity
Concentration 1.00 µM
Cell line A2058
Organism Homo sapiens
Animal model
STAT protein
Other p-JAK2(Tyr1007/1008)
Reference
Novel synthetic derivatives of the natural product berbamine inhibit Jak2/Stat3 signaling and induce apoptosis of human melanoma cells. Molecular oncology Sangkil Nam, Jun Xie, Angela Perkins, Yuelong Ma, Fan Yang, Jun Wu, Yan Wang, Rong-Zhen Xu, Wendong Huang, David A Horne, Richard Jove, 6, 5, None, 2012-06-02, 10.1016/j.molonc.2012.05.002 DOI: 10.1016/j.molonc.2012.05.002 PUBMED: 22717603 PMCID: PMC3439602