Name	Value
Compound	BBMD3 (berbamine derivative)
Investigated event	Influence on JAK2 phosphorylation
Experiment type	Autophosphorylation kinase activity
Concentration	0.10 µM
Cell line	A2058
Organism	Homo sapiens
Animal model
STAT protein
Other	p-JAK2(Tyr1007/1008)

Novel synthetic derivatives of the natural product berbamine inhibit Jak2/Stat3 signaling and induce apoptosis of human melanoma cells. Molecular oncology Sangkil Nam, Jun Xie, Angela Perkins, Yuelong Ma, Fan Yang, Jun Wu, Yan Wang, Rong-Zhen Xu, Wendong Huang, David A Horne, Richard Jove, 6, 5, None, 2012-06-02, 10.1016/j.molonc.2012.05.002 DOI: 10.1016/j.molonc.2012.05.002 PUBMED: 22717603 PMCID: PMC3439602