Investigated event: Inhibition of Jak/STAT signalling

Name Value
Compound BBMD3 (berbamine derivative)
Investigated event Inhibition of Jak/STAT signalling
Experiment type Western Blot
Concentration 10.00 µM
Cell line A375
Organism Homo sapiens
Animal model
STAT protein STAT3
Other
Reference
Novel synthetic derivatives of the natural product berbamine inhibit Jak2/Stat3 signaling and induce apoptosis of human melanoma cells. Molecular oncology Sangkil Nam, Jun Xie, Angela Perkins, Yuelong Ma, Fan Yang, Jun Wu, Yan Wang, Rong-Zhen Xu, Wendong Huang, David A Horne, Richard Jove, 6, 5, None, 2012-06-02, 10.1016/j.molonc.2012.05.002 DOI: 10.1016/j.molonc.2012.05.002 PUBMED: 22717603 PMCID: PMC3439602