Investigated event: Influence on protein activity In presence IL-6
| Name | Value |
|---|---|
| Compound | Galiellalactone |
| Investigated event | Influence on protein activity In presence IL-6 |
| Experiment type | Luciferse activity |
| Concentration | 5.00 µM |
| Cell line | LNCaP |
| Organism | Homo sapiens |
| Animal model | |
| STAT protein | STAT3 |
| Other |
Reference
Galiellalactone is a direct inhibitor of the transcription factor STAT3 in prostate cancer cells. The Journal of biological chemistry Nicholas Don-Doncow, Zilma Escobar, Martin Johansson, Sven Kjellström, Victor Garcia, Eduardo Munoz, Olov Sterner, Anders Bjartell, Rebecka Hellsten, 289, 23, 2014-06-06, 2014-04-22, 10.1074/jbc.M114.564252
DOI: 10.1074/jbc.M114.564252
PUBMED: 24755219
PMCID: PMC4047371