Investigated event: Influence on protein activity

Name Value
Compound Pacritinib
Investigated event Influence on protein activity
Experiment type Western Blot
Concentration 5.00 µM
Cell line BT53
Organism Homo sapiens
Animal model
STAT protein
Other p44/42 MAPK
Reference
The JAK2/STAT3 inhibitor pacritinib effectively inhibits patient-derived GBM brain tumor initiating cells in vitro and when used in combination with temozolomide increases survival in an orthotopic xenograft model. PloS one Katharine Victoria Jensen, Orsolya Cseh, Ahmed Aman, Samuel Weiss, Hema Artee Luchman, 12, 12, None, 2017-12-18, 10.1371/journal.pone.0189670 DOI: 10.1371/journal.pone.0189670 PUBMED: 29253028 PMCID: PMC5734728