Investigated event: Influence on protein activity
| Name | Value |
|---|---|
| Compound | Pacritinib |
| Investigated event | Influence on protein activity |
| Experiment type | Western Blot |
| Concentration | 3.00 µM |
| Cell line | BT69 |
| Organism | Homo sapiens |
| Animal model | |
| STAT protein | STAT3 |
| Other |
Reference
The JAK2/STAT3 inhibitor pacritinib effectively inhibits patient-derived GBM brain tumor initiating cells in vitro and when used in combination with temozolomide increases survival in an orthotopic xenograft model. PloS one Katharine Victoria Jensen, Orsolya Cseh, Ahmed Aman, Samuel Weiss, Hema Artee Luchman, 12, 12, None, 2017-12-18, 10.1371/journal.pone.0189670
DOI: 10.1371/journal.pone.0189670
PUBMED: 29253028
PMCID: PMC5734728