Investigated event: Influence on mRNA expression level in presence of LPS

Name Value
Compound Andrographolide
Investigated event Influence on mRNA expression level in presence of LPS
Experiment type RT-qPCR
Concentration 2.00 µM
Cell line RAW264.7
Organism Homo sapiens
Animal model
STAT protein
Other SOCS3
Reference
Andrographolide acts as an anti-inflammatory agent in LPS-stimulated RAW264.7 macrophages by inhibiting STAT3-mediated suppression of the NF-κB pathway. Journal of ethnopharmacology Ko-Chen Lee, Hen-Hong Chang, Ying-Hui Chung, Tzung-Yan Lee, 135, 3, 2011-06-01, 2011-04-08, 10.1016/j.jep.2011.03.068 DOI: 10.1016/j.jep.2011.03.068 PUBMED: 21497192 PMCID: 21497192