Investigated event: Influence on protein activity in tumor tissue
| Name | Value |
|---|---|
| Compound | Ly5 |
| Investigated event | Influence on protein activity in tumor tissue |
| Experiment type | Western Blot |
| Concentration | 20.00 mg/kg |
| Cell line | OS-17 (xenograft) |
| Organism | Mus musculus |
| Animal model | SCID mice |
| STAT protein | p-STAT3 |
| Other |
Reference
Target specificity, in vivo pharmacokinetics, and efficacy of the putative STAT3 inhibitor LY5 in osteosarcoma, Ewing's sarcoma, and rhabdomyosarcoma. PloS one Peter Y Yu, Heather L Gardner, Ryan Roberts, Hakan Cam, Seethalakshmi Hariharan, Ling Ren, Amy K LeBlanc, Hui Xiao, Jiayuh Lin, Denis C Guttridge, Xiaokui Mo, Chad E Bennett, Christopher C Coss, Yonghua Ling, Mitch A Phelps, Peter Houghton, Cheryl A London, 12, 7, None, 2017-07-27, 10.1371/journal.pone.0181885
DOI: 10.1371/journal.pone.0181885
PUBMED: 28750090
PMCID: PMC5531494